Serotonin syndrome after lithium add-on medication to paroxetine.
Pharmacopsychiatry
; 30(3): 106-7, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9211572
ABSTRACT
A 59-year-old female patient was hospitalized on account of a depressive episode in the course of a long-standing bipolar disorder. On a combination of lithium (400 mg/day) and paroxetine (30 mg/day) she developed symptoms of shivering, high-frequency tremor of the upper and lower limbs, skin flush in the face, agitation, and slight impairment of mental focusing, suggestive of a serotonin syndrome. At this stage serum lithium and paroxetine levels were 0.63 mmol/l, and 693 ng/ml, respectively; the latter was six times higher than the upper concentrations seen in patients on this dosage of the drug. Consequently, the dosage of paroxetine was reduced to 10 mg/day, and lithium was continued. This regimen resulted in a steady-state paroxetine serum level of 390 ng/ml. The patient became symptom-free and the depressive episode attenuated, thus enabling us to discharge the patient.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serotonina
/
Paroxetina
/
Antimaníacos
/
Antidepressivos de Segunda Geração
/
Lítio
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article