[Hypercapnia induced reversible opening of the blood-brain barrier in experimental hyperbilirubinemia]. / Apertura reversible de la barrera hematoencefálica inducida por hipercapnia en hiperbilirrubinemia experimental.
An Esp Pediatr
; 46(4): 374-7, 1997 Apr.
Article
em Es
| MEDLINE
| ID: mdl-9214231
ABSTRACT
OBJECTIVE:
The incidence of bilirubin encephalopathy in extremely ill neonates with low serum bilirubin is stimulating interest in factors that can modify the blood-brain barrier permeability and allow the passage of bilirubin-albumin macrocomplexes, which may be produced by hypercapnia. MATERIALS ANDMETHODS:
Without modifying the normal bilirubin-albumin affinity, we increased cerebral flow by two levels of hypercapnia (PCO2 67.1 and 101.9 mmHg), acquired by inhalation of CO2 enriched air (5 and 15%) and a decrease in pH (7.00 and 6.93).RESULTS:
We demonstrate an increment in cerebral bilirubin deposition (control 2.43 +/- 0.54 mg/g versus 3.29 +/- 0.43 and 3.28 +/- 1.07, F = 4.80, p < 0.05) and I125 albumin (control 26.1 +/- 95.8 micrograms/g versus 364.4 +/- 156.1 and 430.8 +/- 122.4, F03.34, p < 0.05).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Barreira Hematoencefálica
/
Hiperbilirrubinemia
/
Hipercapnia
Limite:
Animals
Idioma:
Es
Ano de publicação:
1997
Tipo de documento:
Article