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Trends in HIV-1 prevalence may not reflect trends in incidence in mature epidemics: data from the Rakai population-based cohort, Uganda.
Wawer, M J; Serwadda, D; Gray, R H; Sewankambo, N K; Li, C; Nalugoda, F; Lutalo, T; Konde-Lule, J K.
Afiliação
  • Wawer MJ; Center for Population and Family Health, Columbia University School of Public Health, New York, USA.
AIDS ; 11(8): 1023-30, 1997 Jul.
Article em En | MEDLINE | ID: mdl-9223737
ABSTRACT
PIP: Findings are reported from a 2-year follow-up study of an open cohort of people aged 15-59 years living in a sample of 31 representative community clusters in rural Rakai district, Uganda, to measure whether trends in serial HIV-1 prevalence reflect trends in HIV incidence, and to gain insight into the effects of HIV-1 incidence, mortality, mobility, and compliance upon HIV-1 prevalence. In each year of study, all consenting adults provided a serological sample and were interviewed; 2591 adults were enrolled at baseline. HIV prevalence among adults declined significantly between 1990 and 1992; from 23.4% in 1990, to 21.8% in 1991, and 20.9% in 1992. Declining prevalence was also observed in subgroups, including young adults aged 15-24 years from 20.6% to 16.2%, reproductive-age women from 27.1% to 23.5%, and pregnant women from 25.4% to 20.0%. The decline in HIV prevalence among pregnant women, however, is not significant. HIV incidence did not change significantly among all adults aged 15-59 years, nor in population subgroups. HIV-related mortality was 13.5/person-year of observation among those who were HIV-positive. Substantial numbers of HIV-infected individuals were also loss to emigration.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Surtos de Doenças / HIV-1 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy País/Região como assunto: Africa Idioma: En Ano de publicação: 1997 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Surtos de Doenças / HIV-1 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy País/Região como assunto: Africa Idioma: En Ano de publicação: 1997 Tipo de documento: Article