N-omega-carbethoxypentyl-4-quinolones: a new class of leukotriene biosynthesis inhibitors.
Arch Pharm (Weinheim)
; 330(4): 100-6, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9230527
ABSTRACT
6-[(4-Quinolinyl)oxy]hexanoic acids and the corresponding esters were designed and synthesized as inhibitors of the production of arachidonic acid metabolites. The inhibitory activities were assayed in vitro by evaluation of serum leukotriene B4 and thromboxane B2 production. While all 6-[(4-quinolinyl)oxy]hexanoic acids and their esters proved to be inactive, the N-alkyl-4-quinolones, obtained as by-products in their synthesis, were found to be a new class of leukotriene biosynthesis inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucotrienos
/
Inibidores de Lipoxigenase
/
Quinolonas
/
Inibidores Enzimáticos
Limite:
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article