Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis.
FEBS Lett
; 410(2-3): 447-51, 1997 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-9237680
ABSTRACT
The ARG-11 gene in Saccharomyces cerevisiae encodes a protein with the characteristic features of a family of 35 related membrane proteins that are encoded in the fungal genome. Some of them are known to transport various substrates and products across the inner membranes of mitochondria, but the functions of 29 members of the family are unknown. The yeast ARG-11 protein has been over-produced as inclusion bodies in Escherichia coli. It has been solubilized in the presence of sarkosyl, re-constituted into liposomes and shown to transport ornithine in exchange for protons. Its main physiological role is probably to take ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol where it is converted to arginine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ornitina
/
Proteínas de Membrana Transportadoras
/
Arginina
/
Proteínas Fúngicas
/
Proteínas de Transporte
/
Proteínas de Saccharomyces cerevisiae
/
Proteínas de Membrana
/
Mitocôndrias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article