Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants.
Neuron
; 19(1): 51-62, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9247263
ABSTRACT
Integrins are heterodimeric cell surface receptors implicated in cell adhesion and signaling. Our analysis of C. elegans ina-1 alpha integrin mutants provides the first genetic evidence that migrating neurons require integrins. Mosaic analysis and expression studies show that ina-1 acts autonomously in cells to promote their migrations. Although axons generally extend to their normal targets in ina-1 mutants, bundling of axons into fascicles is defective, defining a previously unrecognized role for integrins. In addition to these neuronal phenotypes, ina-1 mutants also display many morphogenetic defects. Finally, we show that the C. elegans INA-1 alpha integrin subunit associates with the PAT-3beta subunit in vivo, suggesting that these proteins function together in cell migration, axon fasciculation, and morphogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Integrinas
/
Movimento Celular
/
Mutação
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article