Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma.
Curr Top Microbiol Immunol
; 224: 269-76, 1997.
Article
em En
| MEDLINE
| ID: mdl-9308251
ABSTRACT
In cell lines derived from patients with multiple myeloma (MM) we have found an elevation in the amount of the c-myc protein which is not accompanied by an increase in the level of mRNA or a change in the half-life of the protein. There is a 3.4 fold enhancement in the degree of association of the c-myc message with polysomes. This is not accompanied by an alteration in polysome size or a change in the transit time of the c-myc mRNA on the polysomes thus suggesting that there is in increase in the degree of mobilisation of the c-myc message. Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and we demonstrate that this mutation causes altered binding of cellular proteins to this RNA species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes myc
/
Mieloma Múltiplo
Limite:
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article