Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin.
FEBS Lett
; 414(2): 381-6, 1997 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-9315724
ABSTRACT
We have isolated a novel retina-specific gene, retinal fascin, encoding a new member of actin-bundling protein gene family, from a bovine retina cDNA library. The cDNA encodes a 492 amino acid protein which shows 36-57% amino acid identity with three vertebrate fascins, echinoid fascin and Drosophila singed gene. Northern blot analysis revealed that retinal fascin mRNA was exclusively expressed in the eye and not seen in other tissues examined. In situ hybridization analysis indicated that retinal fascin mRNA signals were found only in the inner segment of the photoreceptor layer and outer nuclear layer, indicating that retinal fascin was specifically expressed in photoreceptor cells. As fascins are actin-bundling proteins important for constructing several intracellular structures, retinal fascin might play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras
/
Transcrição Gênica
/
Proteínas de Transporte
/
Proteínas dos Microfilamentos
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article