Chronic otitis media treated topically with ciprofloxacin or tobramycin.
Arch Otolaryngol Head Neck Surg
; 123(10): 1057-60, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9339980
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of ciprofloxacin compared with tobramycin and placebo ear drops in the treatment of chronic suppurative otitis media without cholesteatoma.DESIGN:
Sixty ears (in 51 patients) were randomly divided into 3 treatment groups ciprofloxacin hydrochloride, tobramycin, and placebo interventions.SETTING:
The otolaryngology department of a university teaching hospital. INTERVENTION All ears were treated topically for 3 weeks. MAIN OUTCOMEMEASURES:
Each patient received a small, numbered bottle and was instructed to instill 5 drops 3 times daily for 3 weeks. The final clinical and bacteriologic assessment was made after 3 weeks.RESULTS:
The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. Its sensitivity to ciprofloxacin and tobramycin was 94.2% and 70.6%, respectively. The clinical response was 78.9%, 72.2%, and 41.2% in the ciprofloxacin, tobramycin, and placebo groups, respectively. The bacteriologic response rate was 66.7% for the ciprofloxacin and tobramycin groups and 20% for the placebo group. Treatment with ciprofloxacin ear drops seemed to be as effective as treatment with tobramycin.CONCLUSION:
While the lack of ototoxicity of ciprofloxacin was not tested in our study, this treatment may be considered as a potential topical therapy for cases of chronic suppurative otitis media.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média
/
Tobramicina
/
Ciprofloxacina
/
Anti-Infecciosos
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article