Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. Fédération National des Centres de Lutte contre le SIDA.
AIDS
; 11(12): F101-5, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9342061
ABSTRACT
OBJECTIVE:
To assess the clinical and economic consequences of the use of protease inhibitors in the treatment of HIV infection.DESIGN:
Multicentric, observational, retrospective cohort study.SETTING:
Ten AIDS reference centres in France. PATIENTS All patients followed in each centre from September 1995 through October 1996. MAIN OUTCOMEMEASURES:
AIDS-defining events, death, health-care resources use, administration of antiretroviral therapy.RESULTS:
Data from 7749 patients in 10 centres showed a drop in hospitalization days by 35%, new AIDS cases by 35%, and deaths by 46%. In the same period, the proportion of patients receiving antiretrovirals rose from 36 to 53% including highly active antiretroviral therapy (HAART), which rose from 0.3 to 18%. Overall cost evaluation showed a slight increase of monthly treatment cost of US$ 12 per patient. Comparison of the three centres that used HAART earliest to the three centres that used it latest showed a clear benefit to early HAART with a drop in hospitalization days by 41%, new AIDS cases by 41% and deaths by 69%. The proportion of patients with HAART rose to 27% and monthly health-care cost decreased by US$ 248852 (i.e., by US$ 101 per patient per month). Late prescribing centres experienced a less marked effect with a drop in hospitalization days by 22%, new AIDS cases by 31%, and deaths by 32.5%. Proportion of patients with HAART rose to 12% and monthly health-care costs increased by US$ 113578 (i.e., by US$ 38 per patient per month).CONCLUSIONS:
This study supports the extensive use of HAART in HIV-infected patients.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome da Imunodeficiência Adquirida
/
Inibidores da Protease de HIV
/
Fármacos Anti-HIV
/
Hospitalização
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article