Adaptive survival trials.
J Biopharm Stat
; 7(4): 617-24, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9358333
ABSTRACT
We present a design for adaptive survival trials, where the probability of randomization to one of two treatments is skewed away from 0.5 according to the current value of the logrank statistic. A formula mapping the logrank statistic onto [0,1] is given, which is then used to bias a coin used for randomization. Simulation evidence shows that the allocation scheme works well and offers a more ethical alternative when lifetime data are available from other patients during the recruitment period. Power is not adversely affected by the resulting unequal allocation. The usual test statistic appears to be standard normal under the proposed allocation scheme.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Taxa de Sobrevida
/
Estatística como Assunto
/
Ensaios Clínicos Fase III como Assunto
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article