Neurotrophin-like immunoreactivity in the human trigeminal ganglion.
Neuroreport
; 8(16): 3611-7, 1997 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-9427336
ABSTRACT
The localization of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3) was demonstrated immunohistochemically in discrete neuronal subsets of the human trigeminal ganglion at ages ranging from 23 weeks of gestation to adulthood. Neurotrophin-containing subpopulations partially overlapped with each other and with those immunoreactive for the relevant trk receptor. Glial elements could also be immunostained, labelled satellite cells being particularly abundant in NT-3 stained sections. These results suggest that the neurotrophins are of functional significance for the human trigeminal primary sensory neurones throughout life. Their localization in the ganglion cellular components supports their function as target-derived trophic factors and as molecules effective in autocrine/paracrine interactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gânglio Trigeminal
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Receptores de Fator de Crescimento Neural
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Fatores de Crescimento Neural
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Neurônios
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article