Part of the RBM gene cluster is located distally to the DAZ gene cluster in human Yq11.23.
Chromosome Res
; 5(8): 537-40, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9451953
ABSTRACT
Normal human Y and inverted Y chromosomes were chosen for physical fluorescence in situ hybridization (FISH) mapping of RBM and DAZ probes for the relative positioning of the RBM and DAZ gene clusters in interval 6 of the human Y chromosome. The inversion breakpoint in Yq11.23 turned out to be distal to the DAZ gene cluster, as the entire DAZ signal appears in the short arm of the inv(Y) chromosome. On the contrary, this inversion breakpoint in Yq11.23 divides the RBM signal cluster, leaving a weaker signal on the long arm while bringing the main RBM signal to the short arm of the inv(Y) chromosome. Thus, it can be concluded that, in contrast to previous claims, part of the RBM gene cluster is located distally to the DAZ gene cluster in deletion interval 6 of the human Y chromosome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomo Y
/
Família Multigênica
/
Mapeamento Cromossômico
/
Proteínas de Ligação a RNA
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article