Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype.
Calcif Tissue Int
; 62(3): 278-81, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9501964
ABSTRACT
This investigation of 219 hemodialysis patients relates the history and prospective risk of bone fractures to apolipoprotein E (apoE) genotype. A greater percentage of the 41 patients with the E3/4 and E4/4 genotypes than of the 38 patients with the E2/3 and E2/2 genotypes had a history of bone fractures at the time of recruitment (44% versus 16%, P < 0.005). During the 4 years following recruitment, more of the patients with apoE genotypes E3/4 and E4/4 than with apoE genotypes E2/3 and E2/2 suffered bone fractures, but this difference was not statistically significant (17.1 versus 5.3%, P < 0.1). ApoE genotype appears to be an important genetic risk factor for bone fracture, possibly due to its previously reported influence on vitamin K concentrations in blood.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Osso e Ossos
/
Diálise Renal
/
Fraturas Ósseas
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Adult
/
Aged
/
Aged80
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article