Co-localization of polar replication fork barriers and rRNA transcription terminators in mouse rDNA.
J Mol Biol
; 277(2): 249-56, 1998 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-9514756
ABSTRACT
We investigated the replication of the region where transcription terminates in mouse rDNA. It contains a replication fork barrier (RFB) that behaves in a polar manner, arresting only replication forks moving in the direction opposite to transcription. This RFB consists of several closely spaced fork arrest sites that co-localize with the transcription terminator elements, known as Sal boxes. Sal boxes are the target for mTTF-I (murine transcription termination factor I). These results suggest that both termination of rRNA transcription and replication fork arrest may share cis-acting as well as trans-acting factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Ribossômico
/
RNA Ribossômico
/
Replicação do DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article