A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix.
Cancer Res
; 58(6): 1140-3, 1998 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-9515797
ABSTRACT
Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 19
/
Síndrome de Peutz-Jeghers
/
Adenoma
/
Neoplasias do Colo do Útero
/
Genes Supressores de Tumor
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article