Human bone bank allografts stimulate bone resorption and inhibit proliferation in cultures of human osteoblast-like cells.
Acta Orthop Scand
; 69(1): 63-8, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9524521
ABSTRACT
Incorporation of a frozen human bone allograft requires osteoclast activity and ingrowth of recipient osteoblast precursors. We examined the effects of allografts on human osteoblasts. Allografts stimulated a release of factors from normal human osteoblast-like cells, capable of inducing osteoclastic bone resorption in vivo. Further allografts inhibited osteoblast proliferation in cultures. The response was detectable within 4 days of culture and was still present after 3 weeks. Devitalized bone autografts had a similar effect. This suggests that bone bank grafts may induce a resorptive reaction at the recipient site by stimulating release of factors from osteoblasts capable of inducing osteoclastic resorption. The storage temperature was crucial for preservation of the response, since the activity was lower in allografts stored for 6 months at -20 degrees C than in those stored at -80 degrees C.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Reabsorção Óssea
/
Transplante Ósseo
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article