Nucleotide sequence of nucleocapsid protein (N) of Hantaan virus isolated from a Korean hemorrhagic fever patient.
DNA Seq
; 7(6): 349-52, 1997.
Article
em En
| MEDLINE
| ID: mdl-9524814
ABSTRACT
The nucleotide sequence of the nucleocapsid protein (N) coding region of a Hantaan virus strain (CFC94-2) isolated from a Korean Hemorrhagic Fever (KHF) patient was determined by sequencing a series of deletion mutants. Comparison of the N coding sequence of CFC94-2 to the sequence of the prototype of Hantaan virus, strain 76-118 reveals a 4.97% difference in the nucleotide sequence and a 1.6% difference in the deduced amino acid sequence. The rate of amino acid sequence variation in N protein of different Hantaan viruses (1.6%) is quite similar to that in G1 and G2 envelope proteins (1.7%). These results suggest that N protein may be under a similar selection pressure to G1 and G2 envelope proteins against host immune system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Core Viral
/
Capsídeo
/
Vírus Hantaan
/
Proteínas do Capsídeo
/
Febre Hemorrágica com Síndrome Renal
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article