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Characterisation of furoxancarbonitriles as a new class of vasodilators.
Gasco, A M; Boschi, D; Di Stilo, A; Medana, C; Gasco, A; Martorana, P A; Schönafinger, K.
Afiliação
  • Gasco AM; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Italy.
Arzneimittelforschung ; 48(3): 212-8, 1998 Mar.
Article em En | MEDLINE | ID: mdl-9553676
The synthesis, structural characterization, NO-donor properties, and in vitro vasodilating activities of a series of furoxancarbonitriles 2, 17-22a, b are reported. Some derivatives (2b, 2a, 18b, 21b, 22b) are more potent vasodilating agents than sodium nitroprusside (SNP), the reference compound, some others display similar potency (17b, 19b, 20b). Log EC50 values fit well on the linear correlation log EC50 versus log C0.1(1 min) (namely the logarithm of the concentration able to release 2.6 mumol l-1 min-1 of NO) found in a previous work. The haemodynamic profile in anaesthetised pigs for some selected derivatives (2a, b, 19a, b) is also presented. These profiles are consistent with that known for another furoxan NO-donor (4-hydroxymethyl-3-furoxancarboxamide, CAS 1609) and suggest similar characteristic of in vivo NO-release.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Vasodilatadores / Hemodinâmica / Nitrilas Limite: Animals Idioma: En Ano de publicação: 1998 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Vasodilatadores / Hemodinâmica / Nitrilas Limite: Animals Idioma: En Ano de publicação: 1998 Tipo de documento: Article