Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.
Genetics
; 148(4): 1941-9, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9560407
ABSTRACT
Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex-linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J x B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliomielite
/
Mapeamento Cromossômico
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Theilovirus
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Predisposição Genética para Doença
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article