[Comparison of immunogenicity of vaccination and serovaccination against hepatitis B virus in patients with alcoholic cirrhosis]. / Comparaison de l'immunogénicité de la vaccination et de la sérovaccination contre le virus de l'hépatite B chez les malades atteints de cirrhose alcoolique.
Gastroenterol Clin Biol
; 21(11): 848-53, 1997.
Article
em Fr
| MEDLINE
| ID: mdl-9587536
ABSTRACT
OBJECTIVES:
The association of anti-HBs immunoglobulins and anti-HBV vaccine could increase the immunogenicity of the latter. The aim of this prospective randomized trial was to compare the immunogenicity of anti-HBs vaccination and serovaccination in alcoholic patients with cirrhosis.METHODS:
Alcoholic patients with cirrhosis were randomized in 2 groups a) Vaccination group 3 i.m. injections of GenHevac B followed by one booster at month 9; b) Serovaccination group same vaccination schedule followed by one i.m. injection of anti-HBs immunoglobulins (500 IU).RESULTS:
Twenty-five patients (17 males and 8 females, mean age 56 years) were included in the study 13 received a vaccination and 12 received a serovaccination. After 12 months, the seroconversion rates were 69% and 67% in vaccination and in serovaccination groups, respectively. The predictive factors of non responsiveness were as following Child B cirrhosis, low number of CD8, a high CD4/CD8 rate, the existence of HLA DR7 antigen, and the absence of HLA DR1 antigen.CONCLUSION:
In alcoholic patients with cirrhosis, serovaccination does not increase the immunogenicity of anti-HBs vaccination and should not be recommended.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunização Passiva
/
Vacinação
/
Hepatite B
/
Cirrose Hepática Alcoólica
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Ano de publicação:
1997
Tipo de documento:
Article