Inhibitory effect of radiosensitizer AK-2123 on experimental hepatic metastases and Ca2+ active transport.
Neoplasma
; 44(6): 361-5, 1997.
Article
em En
| MEDLINE
| ID: mdl-9605008
ABSTRACT
A triazole group radiosensitizer AK-2123 is shown to inhibit considerably the growth of hepatic metastases induced by the intrasplenic injection of colon adenocarcinoma cells in syngenic mice. Even an extremely low dose of the drug exhibits the antimetastatic effect. It is shown that AK-2123 injected at therapeutic dose inhibits active transport of calcium ions by the (Ca2+-Mg2+)-dependent ATP-ase. The antimetastatic effect of AK-2123 is suggested to be related, at least partially, to the inhibition of the active calcium transport.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radiossensibilizantes
/
Triazóis
/
Adenocarcinoma
/
Cálcio
/
Neoplasias Hepáticas
/
Metástase Neoplásica
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article