Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature.
Cancer Res
; 58(13): 2784-92, 1998 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-9661892
ABSTRACT
The novel aminosterol, squalamine, inhibits angiogenesis and tumor growth in multiple animal models. This effect is mediated, at least in part, by blocking mitogen-induced proliferation and migration of endothelial cells, thus preventing neovascularization of the tumor. Squalamine has no observable effect on unstimulated endothelial cells, is not directly cytotoxic to tumor cells, does not alter mitogen production by tumor cells, and has no obvious effects on the growth of newborn vertebrates. Squalamine was also found to have remarkable effects on the primitive vascular bed of the chick chorioallantoic membrane, which has striking similarities to tumor capillaries. Squalamine may thus be well suited for treatment of tumors and other diseases characterized by neovascularization in humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticarcinógenos
/
Neovascularização Fisiológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article