Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.
Science
; 281(5375): 416-9, 1998 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-9665885
ABSTRACT
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Linfócitos T
/
Leucopoese
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article