The role of erythrocytes in the inactivation of free radicals.
Med Hypotheses
; 50(5): 363-7, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9681913
ABSTRACT
We propose that, in addition to its function of gas exchange, the erythron provides a mechanism for the inactivation of reactive oxygen and oxide radicals in vivo. In carrying out this function, individual erythrocytes undergo changes in biochemical and structural properties, which are reflected by shape and functional alterations. The changes indicate damage to the labile components of the red cell and demonstrate the expendable nature of the individual red cell. We propose that a superoxide anion channel allows the transport of superoxide and other free radicals into the red cell, where they are deactivated by the erythrocyte antioxidant system which effectively prevents extensive oxidative damage to tissues.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espécies Reativas de Oxigênio
/
Superóxidos
/
Eritrócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article