Affective disorder associated with a balanced translocation involving chromosome 14 and 18.

We report a case of a women with psychiatric illness that includes bipolar disorder who has a karyotype of 46,XX,t(14;18)(q11.2;q22.1). The region on chromosome 18 that is involved in the translocation has been implicated in other families through linkage and association studies as possibly containing a gene for bipolar illness.