Prevalence of mutation associated to resistance with nucleoside analogues in a cohort of naïve HIV-1 positive subjects during the period 1984-1997.
J Biol Regul Homeost Agents
; 12(1-2 Suppl): 32-4, 1998.
Article
em En
| MEDLINE
| ID: mdl-9689577
ABSTRACT
We examined samples from 98 naïve HIV-1 positive patients with the seroconversion period between 1984 and 1997, 64 of whom with a diagnosed primary infection. We observed a progressive increase in the percentage of patients harboring mutations associated with zidovudine resistance, starting from 8% during the period 1987-1994 to 20% and 36% in patients with HIV infection diagnosed during 1996 and 1997 respectively. The small number of patients analyzed in groups 3 and 4 is an important limitation to establish the real increase in the prevalence of mutations we observed during the past two years. However, it is important to underline the trend and, in our opinion, further studies to better define the relevance of such phenomenon in the clinical practice must be performed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência Microbiana a Medicamentos
/
Infecções por HIV
/
Inibidores da Transcriptase Reversa
/
Transcriptase Reversa do HIV
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Mutação
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article