Sentinel lymph node localization in early breast cancer.
J Nucl Med
; 39(8): 1388-93, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9708514
ABSTRACT
METHODS:
Thirty-two patients with clinical node-negative breast cancer underwent sentinel node localization study as part of a National Cancer Institute-sponsored multicenter trial. Anatomical and histopathologic characteristics of sentinel lymph node (SLN) and a kinetic analysis of nodal uptake were studied. Patients were injected with 1 mCi/4 ml unfiltered 99mTc-sulfur colloid in four divided doses around the palpable lesion or immediately adjacent to the excision cavity if prior biopsy was performed. SLN biopsy was performed 1.5-6 hr (mean = 3 hr) postinjection. Intraoperative localization was performed using a gamma probe. All patients underwent complete axillary dissection.RESULTS:
SLN was identified in 30 of 32 (94%) patients. There were no false-negative SLN biopsies.CONCLUSION:
This study supports the clinical validity of SLN biopsy in breast cancer and confirms that, unlike the blue dye technique, the learning curve with unfiltered 99mTc-sulfur colloid and the gamma detection probe is short, and SLN localization is achievable in over 90% of cases by surgeons with modest experience. The use of unfiltered 99mTc-sulfur colloid (larger particle size) with larger injected volume permits effective localization of SLNs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coloide de Enxofre Marcado com Tecnécio Tc 99m
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Neoplasias da Mama
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Carcinoma Ductal de Mama
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Compostos Radiofarmacêuticos
/
Linfonodos
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article