Bacterial death by DNA gyrase poisoning.
Trends Microbiol
; 6(7): 269-75, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9717215
ABSTRACT
DNA gyrase is an essential topoisomerase that is found in all bacteria and is the target of potent antibiotics, such as the quinolones. By creating DNA lesions and inducing the bacterial SOS response, these drugs are not only highly cytotoxic but also mutagenic. Discovery and analysis of natural molecules with anti-gyrase activities, such as the CcdB or microcin B17 proteins, hold promise for understanding further topoisomerase reactions and for the design of new antibiotics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Proteínas de Bactérias
/
Toxinas Bacterianas
/
Inibidores da Topoisomerase II
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article