Functionalization of designed folded polypeptides.

ABSTRACT

Recent progress in the design of folded polypeptides has led to new catalysts, peptides that bind metal ions, hemes and cofactors, and folded glycopeptides. The development of techniques for postsynthetic and post-translational functionalization promises to further expand the repertoire of accessible motifs. The demonstration of function in complex sites helps to understand protein structure and function and has important implications for the engineering of new proteins with novel properties.