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CD34+-enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation.
Selleri, C; Raiola, A; De Rosa, G; Luciano, L; Pezzullo, L; Picardi, M; Rotoli, B.
Afiliação
  • Selleri C; Division of Hematology, Federico II University Medical School, Naples, Italy.
Bone Marrow Transplant ; 22(6): 605-7, 1998 Sep.
Article em En | MEDLINE | ID: mdl-9758354
ABSTRACT
A variety of immunohematological complications may occur after ABO-incompatible BMT. We report a CML patient (blood group O) who received a BMT from an HLA-identical sibling (blood group AB). The transplant was followed by normal myeloid and megakaryocytic engraftment, but erythroblastopenia persisted for more than 200 days after BMT. By bone marrow culture studies, a complement-dependent serum inhibitor of hemopoiesis was detected, suggesting immunological inhibition of erythropoiesis. The patient was resistant to a number of treatments such as intravenous gamma-globulins, prednisolone and high-dose erythropoietin. Full engraftment with normal blood counts and marrow cellularity was achieved after two dose-escalating CD34+-enriched donor lymphocyte infusions (DLI). This experience suggests that CD34+-enriched DLI may be an effective treatment for patients with delayed engraftment or late graft failure due to major ABO-incompatibility.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Aplasia Pura de Série Vermelha / Transfusão de Linfócitos / Antígenos CD34 / Rejeição de Enxerto Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Medula Óssea / Aplasia Pura de Série Vermelha / Transfusão de Linfócitos / Antígenos CD34 / Rejeição de Enxerto Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article