The intact isolated (ex vivo) retina as a model system for the study of excitotoxicity.
Prog Retin Eye Res
; 17(4): 465-83, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9777647
ABSTRACT
Excitotoxicity is defined as a mode of neural cell death triggered by overactivation of receptors for the amino acid transmitter glutamate. There is considerable evidence that excitotoxicity is responsible for cell death in several neuropathological states, including some retinal diseases. The isolated retina, particularly from chick embryos, has been used extensively as an experimental system to characterize this process. This paper summarizes the use of isolated retina as a model system for studies of excitotoxicity from a theoretical and methodological point of view, and reviews results obtained from studies utilizing this system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Receptores de Glutamato
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article