Test type influences the expression of lithium chloride-induced hyperalgesia.
Pharmacol Biochem Behav
; 61(4): 385-94, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9802833
ABSTRACT
The hyperalgesic properties of the emetic drug lithium chloride (LiCl) were examined in eight experiments. At a dose of 63.6 mg/kg, LiCl produced hyperalgesia in the radiant-heat (Experiment la) and immersion (Experiment 1b) tail-flick tests. At doses of 15.9, 31.8, 63.6, and 127.2 mg/kg, LiCl failed to produce hyperalgesia during the delayed behavioral response in the formalin test (Experiments 2a and 2b), but 63.6 mg/kg LiCl did produce hyperalgesia during the normally quiescent, interphase period of formalin responding (Experiment 2c). At the dose of 63.6 mg/kg, LiCl did not produce hyperalgesia in the hotplate test (Experiments 3a and 3b) and did not exert significant motoric effects in a step-down passive-avoidance task (Experiment 4). The results were discussed with reference to the behavioral effects of LiCl and their implications for demonstrations of associatively mediated morphine analgesic tolerance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cloreto de Lítio
/
Antimaníacos
/
Hiperalgesia
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article