Transactivation by expression of the hepatitis B virus X protein with an inducible system.
Mol Biol Rep
; 25(4): 231-6, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9870613
ABSTRACT
We describe here the conditional expression of the hepatitis B virus X protein using the inducible system controlled by a tet-responsive promoter. Induction of the X protein in Rat-2 fibroblasts activated transcription from a heterologous gene promoter and stimulated the DNA-binding activity of NFkB. The ability to produce this biologically active X protein in a stable cell line will accelerate the elucidation of the function and mechanisms of X and eventually help us understand the role of X in natural viral infection and carcinogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Transcricional
/
Transativadores
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article