The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice.
Nucl Med Commun
; 19(12): 1177-9, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-9885808
ABSTRACT
Drug therapy can alter the biodistribution of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of 99Tcm-methylene diphosphonic acid (99Tcm-MDP). Three doses of mitomycin-C were administered. After the last dose, 99Tcm-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in 99Tcm-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered 99Tcm-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medronato de Tecnécio Tc 99m
/
Mitomicina
/
Compostos Radiofarmacêuticos
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article