Hydrophobic lung surfactant proteins B and C remain associated with surface film during dynamic cyclic area changes.
Biochim Biophys Acta
; 1453(1): 126-34, 1999 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-9989252
ABSTRACT
The biophysical activity of lung surfactant depends, to a large extent, on the presence of the hydrophobic surfactant proteins B (SP-B) and C (SP-C). The role of these proteins in lipid adsorption and lipid squeeze-out under dynamic conditions simulating breathing is not yet clear. Therefore, the aim of this study was to investigate the interaction of spread hydrophobic surfactant proteins with phospholipids in a captive-bubble surfactometer during rapid cyclic area changes (6 cycles/min). We found that SP-B and SP-C facilitated the rapid transport of lipids into the air-water interface in a concentration-dependent manner (threshold concentration > or = 0.050.5 mol% SP-B/SP-C). Successive rapid cyclic area changes did not affect the concentration-dependent lipid adsorption process, suggesting that SP-B and SP-C remained associated with the surface film.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Proteolipídeos
/
Surfactantes Pulmonares
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article