The intramitochondrial ATP/ADP-ratio controls cytochrome c oxidase activity allosterically.
FEBS Lett
; 443(2): 105-8, 1999 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-9989584
ABSTRACT
Recently the signal transduction function for oxidative phosphorylation was found to be second order in ADP [Jeneson, J.A.L., Wiseman, R.W., Westerhoff, H.V. and Kushmerick, M.J. (1996) J. Biol. Chem. 271, 27995-279981, but the molecular mechanism of signal transduction remained unclear. Previously we described inhibition of cytochrome c oxidase by intramitochondrial ATP, accompanied by a change of hyperbolic into sigmoidal kinetics. The present study describes a sigmoidal relationship also between the ascorbate respiration of reconstituted cytochrome c oxidase and intraliposomal ADP concentration. Its possible role in the control of oxidative phosphorylation and cell respiration is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Difosfato de Adenosina
/
Trifosfato de Adenosina
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Mitocôndrias Cardíacas
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article