Canine atopic dermatitis: systemic immunomodulatory protocol based on clinical phenotype / Dermatite atópica canina: protocolos imunomodulatórios sistêmicos baseados no fenótipo clínico

Canine atopic dermatitis (cAD) is a multifactorial allergic disease associated with immune dysfunction and abnormal skin barrier. Several immunological mediators play a role in its pathogenesis. Such molecules are produced by the activation of T helper lymphocytes (Th) through polarization to Th1 and/or Th2, which contributes to different lesion patterns. Acute lesions are mediated by an activation of the Th2 cytokine axis, which clinically induces erythema and pruritus. Conversely, in chronic injuries a mixed immune response of Th1/Th2 cytokines occurs, leading to hyperpigmented and lichenified skin. The clinical understanding of these patterns and the mode of action of immunomodulators are crucial for the best clinical management of the atopic patient. In this context, this review discussed the role of the immune response and the immunomodulatory drugs in dogs with atopic dermatitis and suggested a therapeutic protocol based on clinical phenotype. Based on the evidences showed in this review, it is considered appropriate to use immunomodulatory drugs that target cytokine spectrum related with the clinical phenotype of cAD.

A dermatite atópica canina (DAC) é uma doença alérgica multifatorial associada à disfunção imune e barreira cutânea anormal. Vários mediadores imunológicos desempenham um papel na sua patogênese. Tais moléculas são produzidas pela ativação de linfócitos T auxiliares (Th) por meio da polarização para Th1 e/ou Th2, o que contribui para diferentes padrões de lesão. Lesões agudas são mediadas pela ativação do eixo de citocinas Th2, que clinicamente induz eritema e prurido. Por outro lado, nas lesões crônicas ocorre uma resposta imune mista de citocinas Th1/Th2, levando à pele hiperpigmentada e liquenificada. O entendimento clínico desses padrões e o modo de ação dos imunomoduladores são cruciais para o melhor manejo clínico do paciente atópico. Esta revisão visa discutir o papel da resposta imune e das drogas imunomoduladoras em cães com dermatite atópica e sugerir um protocolo terapêutico baseado no fenótipo clínico. Baseado nas evidências apresentadas nessa revisão, é considerado apropriado utilizar drogas imunomoduladoras que abrangem o espectro de citocinas relacionadas ao fenótipo clínico da DAC.

Teste cutâneo de puntura para seleção de imunógenos em dermatite atópica canina / Skin prick test for selection of imungens in canine atopic dermatitis

Dermatite atópica canina é uma doença comum na clínica de pequenos animais e interfere negativamente na qualidade de vida dos cães afetados pelo seu caráter inflamatório e crônico, apresentando predisposição genética. Caracteriza-se, clinicamente, por eritema e prurido cutâneo, considerada de caráter multifatorial. Testes intradérmicos podem ser utilizados para diferenciação de hipersensibilidade à picada de pulgas, hipersensibilidade alimentar e dermatite de contato, além de infecções oportunistas como as causadas por bactérias e fungos que podem confundir o diagnóstico definitivo. Este trabalho tem o objetivo de apresentar as estratégias para diagnóstico e tratamento da dermatite atópica, tendo em vista a etiopatogenia, fisiopatologia, informações sob o ponto de vista clínico, fatores ambientais, testes utilizados para a confirmação do diagnóstico e opções terapêuticas.(AU)

Atopic Canine dermatitis is a common disease in the small animal clinic and interferes negatively in the quality of life of dogs affected by its inflammatory and chronic character, presenting genetic predisposition. It is clinically characterized by erythema and cutaneous itching, considered multifactorial in nature. Intradermal tests can be used to differentiate hypersensitivity to flea bites, food hypersensitivity and contact dermatitis, as well as opportunistic infections such as those caused by bacteria and fungi that may confuse the definitive diagnosis. The present work aims to present the strategies for diagnosis and treatment of atopic dermatitis, in view of etiopathogenesis, pathophysiology, clinical information, environmental factors, tests used to confirm the diagnosis and therapeutic options.(AU)

Isoxazolinas no tratamento da demodicidose canina ­ Revisão de literatura / Isoxazolines in the treatment of canine demodicosis ­ literature review / Isoxazolinas en el tratamiento de la demodicosis canina ­ revisión de la literatura

A demodicidose canina é uma dermatopatia parasitária inflamatória comum na rotina clínica. Ela é causada pela proliferação exacerbada do ácaro Demodex spp., e a espécie mais frequentemente encontrada e que causa a doença clínica é o Demodex canis. A doença pode ser classificada conforme a distribuição das lesões e a idade em que elas surgem. Os sinais clínicos mais comuns incluem alopecia, eritema, hiperpigmentação e descamação, e o diagnóstico mais preconizado é o exame parasitológico do raspado cutâneo. Diversos protocolos terapêuticos para a demodicidose canina têm sido estudados, e por muito tempo utilizou-se o amitraz, sendo ao longo dos anos substituído por fármacos da classe das lactonas macrocíclicas, pela praticidade de sua administração. Contudo, mais recentemente, as isoxazolinas (fluralaner, afoxolaner e sarolaner) foram descobertas como miticidas, e nos últimos anos têm demonstrado excelentes resultados. O presente trabalho tem como objetivo realizar uma revisão de literatura sobre as isoxazolinas no tratamento da demodicidose canina.(AU)

Canine demodicosis is an inflammatory parasitic skin disease common in clinical routine. It is caused by the exacerbated proliferation of the Demodex spp., and the most frequently encountered species that causes clinical disease is Demodex canis. The disease can be classified according to the distribution of lesions and the age at which they appear. The most common clinical signs include alopecia, erythema, hyperpigmentation and desquamation, and the most recommended diagnosis is the parasitological examination of the skin scraping. Several therapeutic protocols for canine demodicosis have been studied, and for a long time the main therapeutic of this disease was amitraz, being replaced over the years by drugs of the macrocyclic lactone class due to the practicality of its administration. However, more recently the isoxazolines (fluralaner, afoxolaner and sarolaner) were discovered as miticides, and in recent years they have shown excellent efficacy results, coming to revolutionize the therapy of canine demodicosis. The present study aims to review the literature on isoxazolines in the treatment of canine demodicosis.(AU)

La demodicosis canina es una enfermedad inflamatoria parasitaria de la piel común en la rutina clínica. Es causada por la proliferación exacerbada de Demodex spp., y la especie más frecuente que causa enfermedad clínica es Demodex canis. La enfermedad se puede clasificar según la distribución de las lesiones y la edad en que aparecen. Los signos clínicos más frecuentes incluyen alopecia, eritema, hiperpigmentación y descamación, y el diagnóstico más recomendado es el examen parasitológico del raspado cutáneo. Se han estudiado varios protocolos terapéuticos para la demodicosis canina, y durante mucho tiempo la principal terapéutica de esta enfermedad fue el amitraz, siendo reemplazada con el paso de los años por fármacos de la clase de las lactonas macrocíclicas debido a la practicidad de su administración. Sin embargo, más recientemente se descubrieron las isoxazolinas (fluralaner, afoxolaner y sarolaner) como acaricidas, y en los últimos años han mostrado excelentes resultados de eficacia, llegando a revolucionar la terapia de la demodicosis canina. El presente estudio tiene como objetivo revisar la literatura sobre las isoxazolinas en el tratamiento de la demodicosis canina.(AU)

Rinoscopia como auxiliar no diagnóstico de criptococose felina: Relato de caso / Rhinoscopy as aid in the diagnosis of feline cryptococosis: case report

Criptococose é uma micose sistêmica não contagiosa que acomete, principalmente, felinos. O agente etiológico é uma levedura do gênero Cryptococcus sp., e a sua transmissão ocorre por via aerógena, com a inalação dos esporos que se alojam, principalmente, na cavidade nasal e pulmão. A forma nasal é a mais comum em felinos e as suas manifestações clínicas incluem edema nasofacial, eritema e secreção nasal. O diagnóstico pode ser realizado por meio de cultivo micológico, citologia, histologia e reação em cadeia polimerase. Neste artigo, é apresentado o relato de caso de um felino diagnosticado com criptococose, no qual o diagnóstico de triagem foi realizado por meio de rinoscopia. No atendimento inicial, o animal apresentava hiporexia, reflexo de deglutição constante, engasgos, odor acentuado em região nasal e crepitações pulmonares com evolução de três meses. O diagnóstico foi realizado com o emprego de rinoscopia, que identificou massa interna na região da mucosa nasofaríngea, com posterior biópsia e exame anatomopatológico. Após a confirmação diagnóstica, o paciente foi medicado com itraconazol 10 mg/kg SID, por 5 meses, e teve a resolução de todos os sinais clínicos apresentados. A criptococose deve ser considerada como diagnóstico, diferencial de alterações do sistema respiratório em felinos e a rinoscopia pode ser um recurso diagnóstico importante para auxiliar na conclusão e reconhecimento da enfermidade.(AU)

Cryptococcosis is a non-contagious systemic mycosis that primarily affects felines. Its etiological agent is a yeast of the genus Cryptococcus sp., and its transmission occurs through the air, by inhalation of spores that primarily lodge in the nasal cavity and lungs. The nasal form is the most common in felines and clinical manifestations include nasofacial edema, erythema and nasal discharge. Diagnosis can be made by means of mycological culture, cytology, histology and polymerase chain reaction. This article presents a case of a feline diagnosed with cryptococcosis, in which the screening diagnosis was performed by means of rhinoscopy. In the initial care, the animal presented hyporexia, constant swallowing reflex, choking, accentuated odor in the nasal region and pulmonary crackles with evolution of three months. The diagnosis was made using rhinoscopy, which identified an internal mass in the nasopharyngeal mucosa, and subsequent biopsy and anatomopathological examination. After diagnostic confirmation, the patient was medicated with itraconazole 10 mg/kg SID for 5 months and had resolution of all clinical signs presented. Cryptococcosis should be considered as a differential diagnosis of alterations in the respiratory system in cats and rhinoscopy can be an important diagnostic tool to assist in the conclusion and recognition of this disease.(AU)

Superficial necrolytic dermatitis in a dog

Background: Superficial necrolytic dermatitis (SND), hepatocutaneous syndrome (HCS), metabolic epidermal necrosis (MEN), and necrolytic migratory erythema (NME) are useful terms to describe a disease that likely has a multifactorial etiopathogenesis. SND is a rare and fatal disease characterized by skin lesions and liver disease. Common skin lesions include hyperkeratosis, fissures, erosion, ulceration, crusting, exudation from the paws, face, perianal regions, and pressure points. This case report aimed to report the case of a bitch that developed the rare Superficial Necrolytic Dermatitis disease, emphasizing the clinical signs of the disease, and the importance of complementary exams such as abdominal ultrasound and skin biopsy for the definitive diagnosis. Case: A 9-year-old, mixed-breed, neutered female was referred for clinical examination with 5 months history of hyperkeratosis and ulceration of the paw pads, presenting pain, lameness and weight loss. Abdominal ultrasound revealed a liver with heterogeneous echotexture, mixed echogenicity, irregular and poorly delimited margins with hypoechoic nodules throughout like honeycombs. The gallbladder was visualized with a moderately thick layer. Histological analysis confirmed the diagnosis of SND. Skin biopsies showed an increase in thickness of the epidermis due to irregular hyperplasia and proliferation of keratinocytes in the basal layer of the epidermis, pallor of the spinous layer of the epidermis and important parakeratosis. Due to the progression of the disease, significant worsening of the patient's clinical condition and pain, associated with the impossibility of cure, the animal was submitted to euthanasia. A necropsy was performed to allow assessment of the liver and pancreas. The biopsies showed a severe proliferative chronic hepatitis, steatosis and cholestasis associated with pancreatitis and necrotic multifocal proliferative fibrinopurulent areas in the pancreas. Discussion: Clinical signs such as lethargy, inappetence, weight loss, as well as the dermatological signs presented by this bitch are nonspecific clinical signs and require a deeper clinical, pathological and histopathological diagnostic investigation to reach the diagnosis of this disease. The definitive diagnosis is made on the basis of a characteristic honeycomb pattern in the liver or associated with a neoplastic finding in the pancreas on ultrasound examination and confirmed by histopathological evaluation of skin biopsies. Palliative treatment with corticosteroid anti-inflammatories, improvement in feed quality, with higher nutritional and protein intake and intravenous amino acid supplementation are suggested by some authors as treatment alternatives. However, not all owners can afford a costly lifetime treatment. With the progressive worsening of the condition, many owners opt for euthanasia as a way to shorten the suffering of the animal. This decision is not an easy one to make. Despite the poor prognosis of the disease, treatment options should be tried by veterinarians and owners prior to the option of euthanasia. However, new affordable nutritional and pharmacological strategies to treat or control the disease are needed in order to improve quality of life of SND patients.

Dermatose actínica em cão: relato de caso / Actinic dermatosis in dogs: a cse report

O trabalho tem o objetivo de relatar um caso de Dermatose Actínica em cadela adulta, 8 anos apresentando pele eritematosa. Na avaliação clínica a cadela apresentou os parâmetros normais da espécie, porém devido às lesões observadas foram solicitados exames citológico e parasitológico de pele, que demonstraram a presença de bactérias (cocos), neutrófilos degenerados e fungos dermatófitos além de demodicidose. O tratamento consistiu do uso de inúmeras drogas como itraconazol, amoxicilina com clavulonato de potássio, predinisolona, Sarolaner e imunomoduladores, além de tratamento tópico com cetoconazol shampoo e creme. Geralmente, as piodermites profundas que atingem o folículo de cães e formam feridas ulceradas, causam uma inflamação crônica na pele, por conta de raios-ultravioletas do sol, ou predisposição familiar ou hipersensibilidade microbiana, ou por outras doenças e, normalmente, são reincidentes e não permitem a cura. Entretanto, nesse caso específico, o tratamento permitiu a melhora do animal (~80%).(AU)

The aim of this paper is to report a case of Actinic Dermatosis in an 8-year-old female adult female with erythematous skin. In the clinical evaluation, the animal presented normal parameters for the species, but, due to the lesions observed, cytological and parasitological skin tests were requested, which showed the presence of bacteria (cocci), degenerated neutrophils, and dermatophyte fungi, and demodicidosis. Treatment consisted of the use of numerous drugs such as itraconazole, amoxicillin with potassium clavulonate, predinisolone, Sarolaner, and immunomodulators; in addition to topical treatment with ketoconazole shampoo and cream. Generally, deep pyoderma that reach the follicle of dogs and form ulcerated wounds, cause a chronic inflammation of the skin, due to the sun's ultraviolet rays, or familial predisposition or microbial hypersensitivity, or due to other diseases and, usually, they are recurrent and do not allow healing. However, in this specific case, the treatment allowed the animal to improve (~80%).(AU)

Eritema multiforme e suas características clínico-patológicas em um equino no Brasil / Erythema multiforme and its clinicopathological features in a horse in Brazil

Background: Erythema multiforme (EM) is an immune-mediated skin disease which may manifest as cutaneous or mucocutaneous lesions. It is uncommon in horses. EM lesions have a symmetrical bilateral distribution; they are usually urticarial, necrotizing, and, less commonly, ulcerative. In equines, the trigger is usually unknown, and cases are often classified as idiopathic. Diagnosis is based on a thorough history and physical and histopathological examination of lesions. According to the clinical presentation and histopathological characteristics of the cutaneous lesions, this case is the first report to describe diagnosis and treatment of a horse with EM in Brazil. Case: A Quarter Horse filly was followed clinically for 12 months after sudden onset of skin lesions at 18 months of age. The initial lesions were non-alopecic papules with a symmetrical bilateral distribution. Six months after onset, the skin lesions maintained the original distribution pattern; however, they had progressed to papules and plaques with varying annular, arciform, serpiginous, targetoid, or alopecic appearance. At 8 months, the same distribution pattern and appearance remained, but the lesions had become more severe and extensive, with involvement of the labial commissures and perineal region, without any erosions/ulcerations, scaling/crusting, pain, or pruritus. At 12 months, new nodular lesions were found on the medial and lateral surfaces of the hind limbs, neck, bilateral trunk, and root of the tail. The lesions were firm, non-pruritic, and non-tender on palpation. Swabs were obtained from the papular lesions. Skin specimens were also obtained with a 6-mm punch and via incisional biopsy and histological sections were made. Bacterial and fungal cultures were negative. Appropriate stains did not identify fungal structures, were negative for acid-fast bacilli, and did not reveal any metachromatic granules in the sampled cell population. The histopathological findings were characteristic of immune-mediated disease, with a vacuolar interface dermatitis affecting the hair follicles more than the epidermis, necrotic keratinocytes, lymphocyte satellitosis, leukocytoclastic mixed vasculitis of the mid-dermis and deep dermis, and variable granulation tissue, consistent with erythema multiforme and leukocytoclastic vasculitis. Immunosuppressive therapy with corticosteroids and oral supplementation with omega-3 and omega-6 fatty acids and vitamin E were prescribed. After institution of therapy, no new lesions developed, the existing lesions remained stable (though permanent), and hair regrew in the previously alopecic areas. All physiological parameters remained normal throughout the follow-up period. Discussion: Erythema multiforme is rarely reported in horses. According to our literature review, this is the first description of EM in horses in Brazil. EM should be included in the differential diagnosis of horses that present with plaques in a diverse, geographic distribution and a negative initial dermatological screening examination. Further clinical investigation is warranted, with special attention to potential antigenic triggers. A thorough drug and dietary history and close attention to comorbidities are essential, as the suppression of potential culprit factors has important prognostic value and contributes to the elucidation of EM triggers.(AU)

Lúpus eritematoso sistêmico associado a manifestações neurológicas em cadela da raça Border Collie / Systemic lupus erythematosus associated with neurological manifestations in a Border Collie bitch

Background: Systemic lupus erythematosus (SLE) is an immune-mediated and multisystemic disorder which etiology is believed to be multifactorial. Its clinical signs vary accordingly to affected organs, cutaneous lesions being the most frequently observed. There are few reports of SLE in dogs with neurological manifestations. Therefore, the aim of this report is to describe a case of SLE in a dog with indicative signs of nervous system involvement. Case: A 6-year-old Border Collie bitch was referred to the Veterinary Hospital (HVU) of the University of Uberaba (UNIUBE) with a history of cluster seizures, inappetence and urinary incontinence. Erythema and flaking of nasal plan were noted on physical examination, and splenomegaly on abdominal palpation. Thrombocytopenia and slightly increased ALT were found on blood tests. Ehrlichiosis was suspected and doxycycline was prescribed along with phenobarbital for the control of seizures. In the follow-up visit, the dog was still presenting urinary incontinence, thrombocytopenia and splenomegaly. Also, an ulcer on the nasal mucocutaneous junction was observed. The patient went through a neurological examination which indicated thalamocortical lesion. Cerebrospinal fluid samples were obtained for cytology, culture and canine distemper test, and serology tests for leishmaniasis, toxoplasmosis and neosporosis were done. No alterations were found in these exams. The histopathology of the nasal lesion was proceeded and showed results consistent with lupus erythematosus. It was prescribed a 15-day course of prednisolone at immunosuppressive dose. The patient showed clinical improvement with this treatment. Azathioprine was started along with gradual removal of prednisolone. After twenty days of discontinuation of this drug, the dog presented epileptic seizures, urinary incontinence, thrombocytopenia, increased ALT and worsened nasal lesion. Prednisolone at immunosuppressive dose was reintroduced and the dose of phenobarbital, increased. One week past this, the patient showed inappetence and an extensive hematoma in the thoracic region. Lab exams confirmed drug-induced acute pancreatitis. All medications were interrupted, the patient was hospitalized, and treatment for pancreatitis was initiated, but the dog passed away. Discussion: For involving multiple body systems and for presenting varied clinical signs, diagnosing SLE can be challenging in clinical routine. The dog from this report was a Border Collie; this breed is considered to be predisposed to this disease. The animal had a history of being exposed to solar radiation for a large part of the day, had dyspigmentation of nasal plan and had no application of sunscreen, predisposing the occurrence of SLE. Neurological signs are uncommon in SLE, but the seizures and the urinary incontinence were the main reasons for the dog's guardian to look for medical assistance. The suspicion for SLE was raised due to cutaneous manifestations and persistent thrombocytopenia along with splenomegaly. Histopathological findings are essential for diagnosing SLE, as well as antinuclear antibody tests. Nonetheless, due to financial limitations, this last test was not performed. Azathioprine is an immunomodulating drug largely used along with glucocorticoids when treating SLE; however, this medication is prone to induce side effects as the ones presented by the dog from this report. Therefore, it is concluded that SLE should be considered as a differential diagnosis in patients showing cutaneous, hematological, systemic and neurological manifestations, considering the variety of signs caused by this disorder.(AU)

Celulite juvenil canina – relato de caso / Canine juvenile cellulite - case report

A celulite canina juvenil é uma afecção rara, que acomete, em sua maioria, filhotes entre três semanas e seis meses de idade, cuja patogênese não está completamente elucidada; entretanto, pressupõe-se estar relacionada à falha imunológica e a reações à vacina polivalente, podendo ocorrer predisposição racial. Como manifestações clínicas, o cão apresenta pápulas, pústulas, alopecia, edema, eritema, crostas e cicatrizes, especialmente em pálpebras, lábios e focinhos, sendo também acometido o pavilhão auricular. Além dessas alterações dermatológicas, nota-se linfoadenomegalia regional. O diagnóstico se baseia em exclusão de dermatopatias que mimetizam o quadro clínico, e o tratamento precisa ser realizado de forma precoce e adequada, normalmente se utilizando doses altas de glicocorticoides. Quando iniciada a terapia precoce, o prognóstico é bom, embora as cicatrizes possam ser permanentes. No presente estudo, foi relatado um caso de filhote fêma mestiça de poodle, que começou a apresentar sinais de otite purulenta, lesões edemaciadas, crostosas e supurativas em região periocular, perilabial, mentoniana, pápulas e pústula em pavilhão auricular, linfoadenomegalia de linfonodos submandibulares e poplíteos, sendo que os sintomas começaram após aplicação da vacina polivalente canina. Foi iniciado tratamento à base de glicocorticoide e, devido à resposta rápida à terapia, foi iniciado desmame da medicação, quando a paciente teve quadro de recidiva, que se resolveu após reajustes terapêuticos.

Canine juvenile cellulitis is a rare condition that affects, in its majority, puppies between three weeks and six months of age, whose pathogenesis has not been completely elucidated; however, it is assumed to be related to immunological failure and reactions to the polyvalent vaccine, which may lead to racial predisposition. As clinical manifestations, the dog presents papules, pustules, alopecia, edema, erythema, crusts and scars, especially on the eyelids, lips and snouts, and the ear pinna is also affected. In addition to these dermatological changes, regional lymphadenomegaly is noted. Diagnosis is based on the exclusion of dermatopathies that mimic the clinical picture, and treatment needs to be carried out early and properly, usually using high doses of glucocorticoids. When therapy is started early, the prognosis is good, although scarring may be permanent. In the present study, a case of a crossbred female poodle pup was reported, which began to show signs of purulent otitis, swollen, crusty and suppurative lesions in the periocular, perilabial, mental region, papules and pustules in the pinna, lymphadenomegaly of submandibular lymph nodes and poplites, and the symptoms started after application of the polyvalent canine vaccine. Glucocorticoid-based treatment was started and, due to the rapid response to therapy, weaning from the medication was started, when the patient had a relapse, which resolved after therapeutic adjustments

Celulite juvenil canina relato de caso / Canine juvenile cellulite - case report

A celulite canina juvenil é uma afecção rara, que acomete, em sua maioria, filhotes entre três semanas e seis meses de idade, cuja patogênese não está completamente elucidada; entretanto, pressupõe-se estar relacionada à falha imunológica e a reações à vacina polivalente, podendo ocorrer predisposição racial. Como manifestações clínicas, o cão apresenta pápulas, pústulas, alopecia, edema, eritema, crostas e cicatrizes, especialmente em pálpebras, lábios e focinhos, sendo também acometido o pavilhão auricular. Além dessas alterações dermatológicas, nota-se linfoadenomegalia regional. O diagnóstico se baseia em exclusão de dermatopatias que mimetizam o quadro clínico, e o tratamento precisa ser realizado de forma precoce e adequada, normalmente se utilizando doses altas de glicocorticoides. Quando iniciada a terapia precoce, o prognóstico é bom, embora as cicatrizes possam ser permanentes. No presente estudo, foi relatado um caso de filhote fêma mestiça de poodle, que começou a apresentar sinais de otite purulenta, lesões edemaciadas, crostosas e supurativas em região periocular, perilabial, mentoniana, pápulas e pústula em pavilhão auricular, linfoadenomegalia de linfonodos submandibulares e poplíteos, sendo que os sintomas começaram após aplicação da vacina polivalente canina. Foi iniciado tratamento à base de glicocorticoide e, devido à resposta rápida à terapia, foi iniciado desmame da medicação, quando a paciente teve quadro de recidiva, que se resolveu após reajustes terapêuticos.(AU)

Canine juvenile cellulitis is a rare condition that affects, in its majority, puppies between three weeks and six months of age, whose pathogenesis has not been completely elucidated; however, it is assumed to be related to immunological failure and reactions to the polyvalent vaccine, which may lead to racial predisposition. As clinical manifestations, the dog presents papules, pustules, alopecia, edema, erythema, crusts and scars, especially on the eyelids, lips and snouts, and the ear pinna is also affected. In addition to these dermatological changes, regional lymphadenomegaly is noted. Diagnosis is based on the exclusion of dermatopathies that mimic the clinical picture, and treatment needs to be carried out early and properly, usually using high doses of glucocorticoids. When therapy is started early, the prognosis is good, although scarring may be permanent. In the present study, a case of a crossbred female poodle pup was reported, which began to show signs of purulent otitis, swollen, crusty and suppurative lesions in the periocular, perilabial, mental region, papules and pustules in the pinna, lymphadenomegaly of submandibular lymph nodes and poplites, and the symptoms started after application of the polyvalent canine vaccine. Glucocorticoid-based treatment was started and, due to the rapid response to therapy, weaning from the medication was started, when the patient had a relapse, which resolved after therapeutic adjustments(AU)

Reação imunológica decorrente a transfusão de concentrado de plaquetas em cão / Immunological reaction due to transfusion of platelet concentrate in dog

A transfusão de hemocomponente na medicina veterinária vem aumentando nos últimos anos, com isso aumenta-se também o potencial de reações transfusionais, que eventualmente podem ser fatais. Neste estudo, um cão de 3 meses de idade, fêmea, Sem Raça Definida com diagnóstico de hemoparasitose, realizado a partir de hemograma (anemia regenerativa com visualização de mórula de Ehrlichia canis em leucócitos e trombocitopenia de 80 mil plaquetas/dL) e ultrassonografia (hepatoesplenomegalia), foi encaminhado ao banco de sangue para ser submetido a transfusão de concentrado de plaquetas (CP), visto que apresentava petéquias, sufusões abdominais e havia sofrido alguns episódios de epistaxe. Após exame físico da paciente que se apresentava com parâmetros normais para a espécie, iniciou-se a transfusão do CP pela veia cefálica. Aos 30 minutos do início do procedimento documentou-se sialorréia intensa e eritema cutânea. A transfusão foi interrompida. Aplicou-se 0,5 mg/Kg de dexametasona por via intravenosa, 0,044 mg/Kg de atropina e 0,2 mg/Kg de prometazina ambos por via subcutânea, e em 40 minutos ocorreu normalização dos parâmetros clínicos. A transfusão de concentrado de plaquetas é um procedimento terapêutico e profilático importante no tratamento e prevenção de hemorragias, quando por deficiência numérica ou qualitativa das plaquetas. No entanto, riscos inerentes ao processo devem ser considerados, e expostos ao tutor. Contudo, descrevemos neste relato reação adversa em cão jovem (hipersensibilidade tipo 1) revertida com o uso imediato de corticosteróide associado a um antagonista colinérgico e anti-histaminico.

The transfusion of blood components in veterinary medicine has been increasing in recent years, thereby increasing the potential for transfusion reactions, which can eventually be fatal. In this study, a 3-month-old, female, Non-Breed dog diagnosed with hemoparasitosis, carried out using a complete blood count (regenerative anemia with visualization of Ehrlichia canis morula in leukocytes and thrombocytopenia of 80 thousand platelets/dL) and ultrasonography (hepatosplenomegaly), was referred to the blood bank to undergo a transfusion of platelet concentrate (PC), since she had petechiae, abdominal suffusions and had suffered some episodes of epistaxis. After physical examination of the patient who presented with normal parameters for the species, began the transfusion of PC through the cephalic vein. At 30 minutes from the beginning of the procedure, intense sialorrhea and skin erythema were documented. The transfusion was stopped, and 0.5 mg / kg of dexamethasone was applied intravenously, 0.044 mg / kg of atropine and 0.2 mg / kg of promethazine both subcutaneously. 40 minutes latter occurred normalization of clinical parameters. Platelet concentrate transfusion is an important therapeutic and prophylactic procedure in the treatment and prevention of bleeding, when due to numerical or qualitative platelet deficiency. However, risks inherent to the process must be considered, and exposed to the tutor. In this report, we describe an adverse reaction in a young dog (type 1 hypersensitivity) reversed with the immediate use of corticosteroids associated with a cholinergic and antihistamine antagonist.

Reação imunológica decorrente a transfusão de concentrado de plaquetas em cão / Immunological reaction due to transfusion of platelet concentrate in dog

A transfusão de hemocomponente na medicina veterinária vem aumentando nos últimos anos, com isso aumenta-se também o potencial de reações transfusionais, que eventualmente podem ser fatais. Neste estudo, um cão de 3 meses de idade, fêmea, Sem Raça Definida com diagnóstico de hemoparasitose, realizado a partir de hemograma (anemia regenerativa com visualização de mórula de Ehrlichia canis em leucócitos e trombocitopenia de 80 mil plaquetas/dL) e ultrassonografia (hepatoesplenomegalia), foi encaminhado ao banco de sangue para ser submetido a transfusão de concentrado de plaquetas (CP), visto que apresentava petéquias, sufusões abdominais e havia sofrido alguns episódios de epistaxe. Após exame físico da paciente que se apresentava com parâmetros normais para a espécie, iniciou-se a transfusão do CP pela veia cefálica. Aos 30 minutos do início do procedimento documentou-se sialorréia intensa e eritema cutânea. A transfusão foi interrompida. Aplicou-se 0,5 mg/Kg de dexametasona por via intravenosa, 0,044 mg/Kg de atropina e 0,2 mg/Kg de prometazina ambos por via subcutânea, e em 40 minutos ocorreu normalização dos parâmetros clínicos. A transfusão de concentrado de plaquetas é um procedimento terapêutico e profilático importante no tratamento e prevenção de hemorragias, quando por deficiência numérica ou qualitativa das plaquetas. No entanto, riscos inerentes ao processo devem ser considerados, e expostos ao tutor. Contudo, descrevemos neste relato reação adversa em cão jovem (hipersensibilidade tipo 1) revertida com o uso imediato de corticosteróide associado a um antagonista colinérgico e anti-histaminico.(AU)

The transfusion of blood components in veterinary medicine has been increasing in recent years, thereby increasing the potential for transfusion reactions, which can eventually be fatal. In this study, a 3-month-old, female, Non-Breed dog diagnosed with hemoparasitosis, carried out using a complete blood count (regenerative anemia with visualization of Ehrlichia canis morula in leukocytes and thrombocytopenia of 80 thousand platelets/dL) and ultrasonography (hepatosplenomegaly), was referred to the blood bank to undergo a transfusion of platelet concentrate (PC), since she had petechiae, abdominal suffusions and had suffered some episodes of epistaxis. After physical examination of the patient who presented with normal parameters for the species, began the transfusion of PC through the cephalic vein. At 30 minutes from the beginning of the procedure, intense sialorrhea and skin erythema were documented. The transfusion was stopped, and 0.5 mg / kg of dexamethasone was applied intravenously, 0.044 mg / kg of atropine and 0.2 mg / kg of promethazine both subcutaneously. 40 minutes latter occurred normalization of clinical parameters. Platelet concentrate transfusion is an important therapeutic and prophylactic procedure in the treatment and prevention of bleeding, when due to numerical or qualitative platelet deficiency. However, risks inherent to the process must be considered, and exposed to the tutor. In this report, we describe an adverse reaction in a young dog (type 1 hypersensitivity) reversed with the immediate use of corticosteroids associated with a cholinergic and antihistamine antagonist.(AU)

Ultrasound and endoscopic findings in dogs with lymphangiectasia / [Conclusões ultrassonográfica e endoscópica em cães com linfangiectasia ]

Lymphangiectasia is a heterogenous inflammatory bowel disease characterized by lymphatic vessel dilation, chronic diarrhea and protein loss such as serum albumin and globulin. The most common cause of lymphangiectasia is considered to be the congenital malformation of the lymphatics. The study was conducted between 2012-2015 on 76 dogs suffering from intestinal disorders and manifesting digestive symptoms such as diarrhea or weight loss. In order to assess the origin of disorder, physical examination, biochemistry profile, ultrasound and endoscopic examinations were performed. Ultrasound examination tried to assess the changes of intestines' echogenicity, changes in wall thickness, wall layering and presence of striations or / and speckles (hyperechoic structures along intestinal mucosal layer). Endoscopic examination findings included dilated lacteals (59.2%) and erythema (21.1%). Although increased friability was observed in 33 dogs, it was not considered in the study due to limitations represented by the evaluation of the endoscopic images only. The study proved that an extremely significant statistical correlation exists between the presence of speckles and dilated lacteals in dogs with lymphangiectasia (P<0.05). Up to now, there is no other study to make an association between the white spots observed in ultrasound examination and dilated lacteals revealed after endoscopy in dogs with intestinal lymphangiectasia.(AU)

A linfangiectasia é uma doença inflamatória intestinal heterogênea, caracterizada por dilatação dos vasos linfáticos, diarreia crônica e perda de proteínas, como albumina sérica e globulina. A causa mais comum de linfangiectasia é considerada a malformação congênita dos linfáticos. O presente estudo foi realizado entre 2012 e 2015, em 76 cães que sofrem de distúrbios intestinais e manifestam sintomas digestivos, como diarreia ou perda de peso. Para avaliar a origem do distúrbio, foram realizados exame físico, perfil bioquímico, ultrassonográfico e endoscópico. O exame ultrassonográfico tentou avaliar as alterações da ecogenicidade do intestino, as alterações na espessura da parede, a estratificação e a presença de estrias e / ou de manchas (estruturas hiperecoicas ao longo da camada mucosa intestinal). Os resultados do exame endoscópico incluíram lacteais dilatadas (59,2%) e eritema (21,1%). Embora tenha sido observada maior friabilidade em 33 cães, ela não foi considerada no estudo devido às limitações representadas pela avaliação apenas das imagens endoscópicas. O estudo demonstrou que existe uma correlação estatística extremamente significativa entre a presença de manchas e lacteais dilatadas em cães com linfangiectasia (P <0,05). Até o momento, não há outro estudo para associar as manchas brancas observadas no exame ultrassonográfico e lacteais dilatadas reveladas após endoscopia em cães com linfangiectasia intestinal.(AU)

Eritema multiforme limitado à cavidade oral em um cão: relato de caso / Multiforme erythema limited to the oral cavity in a dog: case report

O eritema multiforme é uma doença incomum em cães, que afeta pele e mucosas, cuja etiologia ainda não foi completamente elucidada. Contudo, o envolvimento exclusivo da cavidade oral é considerado raro, tendo sido descrito poucas vezes até o presente momento. O objetivo deste trabalho é descrever um caso de eritema multiforme limitado à cavidade oral em um canino. Um cão, fêmea, Akita, com sete anos de idade, apresentou histórico de ulcerações na cavidade oral e nas laterais da língua, sem alterações cutâneas ou sistêmicas. O diagnóstico definitivo foi realizado por meio do exame histopatológico da mucosa oral, e a terapia imunossupressora empregada mostrou-se eficaz. Embora o eritema multiforme seja considerado incomum na espécie canina, este relato de caso apresenta a forma mais rara da doença, com poucos casos descritos em medicina veterinária.(AU)

Multiforme erythema is an uncommon disease in dogs that affects the skin and mucous membranes, the etiology of which has not yet been fully elucidated. However, the exclusive involvement of the oral cavity is considered rare, having been described few times until the present moment. The aim of this work is to describe a case of multiforme erythema limited to the oral cavity in a canine. A seven-year-old female dog, akita, presented a history of ulcerations in the oral cavity and on the sides of the tongue, with no cutaneous or systemic changes. The definitive diagnosis was made through the histopathological examination of the oral mucosa and the immunosuppressive therapy used proved to be effective. Although multiforme erythema is considered uncommon in the canine species, this case report presents the rarest form of the disease, with few cases described in veterinary medicine.(AU)

Eritema multiforme limitado à cavidade oral em um cão: relato de caso / Multiforme erythema limited to the oral cavity in a dog: case report

O eritema multiforme é uma doença incomum em cães, que afeta pele e mucosas, cuja etiologia ainda não foi completamente elucidada. Contudo, o envolvimento exclusivo da cavidade oral é considerado raro, tendo sido descrito poucas vezes até o presente momento. O objetivo deste trabalho é descrever um caso de eritema multiforme limitado à cavidade oral em um canino. Um cão, fêmea, Akita, com sete anos de idade, apresentou histórico de ulcerações na cavidade oral e nas laterais da língua, sem alterações cutâneas ou sistêmicas. O diagnóstico definitivo foi realizado por meio do exame histopatológico da mucosa oral, e a terapia imunossupressora empregada mostrou-se eficaz. Embora o eritema multiforme seja considerado incomum na espécie canina, este relato de caso apresenta a forma mais rara da doença, com poucos casos descritos em medicina veterinária.(AU)

Multiforme erythema is an uncommon disease in dogs that affects the skin and mucous membranes, the etiology of which has not yet been fully elucidated. However, the exclusive involvement of the oral cavity is considered rare, having been described few times until the present moment. The aim of this work is to describe a case of multiforme erythema limited to the oral cavity in a canine. A seven-year-old female dog, akita, presented a history of ulcerations in the oral cavity and on the sides of the tongue, with no cutaneous or systemic changes. The definitive diagnosis was made through the histopathological examination of the oral mucosa and the immunosuppressive therapy used proved to be effective. Although multiforme erythema is considered uncommon in the canine species, this case report presents the rarest form of the disease, with few cases described in veterinary medicine.(AU)

Feline plasm cell pododermatitis: case report / Pododermatite plasmocitária felina: relatode caso

Feline Plasmacytic Pododermatitis is an uncommon dermatological disorder that affects one or multiple paw pads and leads to swelling, ulceration, hemorrhage, scaling, erythema, and striation. Its etiopathogenesis is poorly understood, however, an immune-mediated basis is strongly suggested. A two-year-old neutered, mixed breed, male cat was referred to the Veterinary Clinic of the Federal University of Santa Catarina (UFSC), Curitibanos Campus, with a brief clinical history of progressive lesions on palmar and plantar pads for one month. On physical examination, the patient had enlarged popliteal and inguinal lymph nodes, and paw pads with thin, swollen, hyperemic, erythematous, and purple color skin with multiple white striations. Histopathological diagnosis confirmed plasmacytic pododermatitis, and glucocorticoid therapy with prednisolone was prescribed. In the present report, the patient's clinical follow-up was compromised, as the tutor did not perform the prescribed treatment and did not return with the animal for further evaluations.

A pododermatite plasmocitáriafelina é uma desordem dermatológica incomum que acomete os coxins plantares e/ou palmares, levando a edema, ulceração, hemorragia, descamação, eritema e estrias esbranquiçadas. Sua etiologia e patogenia são desconhecidas, mas acredita-se que tenha origem imunomediada. Foi atendido na Clínica Veterinária Escola da UFSC, CampusCuritibanos, um felino, macho, sem raça definida, 2 anos de idade, castrado, com histórico de lesões nos coxins palmares e plantares há um mês, com evolução progressiva. Ao exame físico apresentava-se com os linfonodos poplíteos e inguinais aumentados, além de coxins com pele fina, edemaciada, hiperêmica, com eritema, púrpura e estrias esbranquiçadas. O diagnóstico histopatológico confirmou pododermatite plasmocitária e foi prescrito tratamento à base de prednisolona. Não foi possível acompanhar a evolução clínica do paciente, pois o tutor não realizou o tratamento prescrito e não trouxe o animal para novas avaliações.

Feline plasm cell pododermatitis: case report / Pododermatite plasmocitária felina: relatode caso

Feline Plasmacytic Pododermatitis is an uncommon dermatological disorder that affects one or multiple paw pads and leads to swelling, ulceration, hemorrhage, scaling, erythema, and striation. Its etiopathogenesis is poorly understood, however, an immune-mediated basis is strongly suggested. A two-year-old neutered, mixed breed, male cat was referred to the Veterinary Clinic of the Federal University of Santa Catarina (UFSC), Curitibanos Campus, with a brief clinical history of progressive lesions on palmar and plantar pads for one month. On physical examination, the patient had enlarged popliteal and inguinal lymph nodes, and paw pads with thin, swollen, hyperemic, erythematous, and purple color skin with multiple white striations. Histopathological diagnosis confirmed plasmacytic pododermatitis, and glucocorticoid therapy with prednisolone was prescribed. In the present report, the patient's clinical follow-up was compromised, as the tutor did not perform the prescribed treatment and did not return with the animal for further evaluations.(AU)

A pododermatite plasmocitáriafelina é uma desordem dermatológica incomum que acomete os coxins plantares e/ou palmares, levando a edema, ulceração, hemorragia, descamação, eritema e estrias esbranquiçadas. Sua etiologia e patogenia são desconhecidas, mas acredita-se que tenha origem imunomediada. Foi atendido na Clínica Veterinária Escola da UFSC, CampusCuritibanos, um felino, macho, sem raça definida, 2 anos de idade, castrado, com histórico de lesões nos coxins palmares e plantares há um mês, com evolução progressiva. Ao exame físico apresentava-se com os linfonodos poplíteos e inguinais aumentados, além de coxins com pele fina, edemaciada, hiperêmica, com eritema, púrpura e estrias esbranquiçadas. O diagnóstico histopatológico confirmou pododermatite plasmocitária e foi prescrito tratamento à base de prednisolona. Não foi possível acompanhar a evolução clínica do paciente, pois o tutor não realizou o tratamento prescrito e não trouxe o animal para novas avaliações.(AU)

Ablação total do conduto auditivo em cão com otite crônica / Total ablation of hearing conduct in dog with chronic otite

A otite é uma inflamação do canal auditivo que pode acometer o ouvido externo e médio, sendo sua patogenia dividida em fatores perpetuadores, predisponentes e primários. Os sinais clínicos mais comuns são eritema, dor a palpação, prurido e exsudação. Além do hitórico e anamnese, radiografia, otoscopia e biopsia podem auxiliar no diagnóstico. O tratamento inicial tem o objetivo de controlar os fatores perpetuadores, eliminar os fatores predisponentes e fazer o controle da causa base. Nos casos de otite externa crônica recidivante, estenose do canal auditivo, deformidades auriculares, pólipos e neoplasias, indica-se fazer o tratamento cirúrgico. O presente trabalho relata o caso de um canino sem raça definida, com treze anos de idade, atendido no Hospital Veterinário da Universidade Federal Rural do Semi-árido (UFERSA), apresentando odor fétido no pavilhão auricular, excesso de cerúmen de coloração escura, eritema, prurido e dor aguda a palpar-se a base do pavilhão auricular esquerdo. Através da anamnese, exame físico e dos exames complementares como a radiografia, o animal foi diagnosticado com otite crônica. Optouse, então, pelo tratamento cirúrgico de ablação total do conduto auditivo (TECA), que consiste na retirada do canal vertical e horizontal do ouvido, associado à osteotomia lateral da bula timpânica. O procedimento cirúrgico foi eficaz no tratamento da otite crônica não responsiva ao tratamento medicamentoso realizado previamente nos últimos cinco anos feito de forma intermitente pelo tutor.

Otitis is an inflammation of the ear canal that can affect the outer and middle ear, and its pathogenesis is divided into perpetuating, predisposing and primary factors. The most common clinical signs are erythema, pain on palpation, itching and oozing. In addition to the history and anamnesis, radiography, otoscopy and biopsy can assist in the diagnosis. The initial treatment aims to control the perpetuating factors, eliminate predisposing factors and control the underlying cause. In cases of recurrent chronic external otitis, stenosis of the ear canal, ear deformities, polyps and neoplasms, surgical treatment is indicated. The present work reports the case of a 13-year-old mixed breed canine, attended at the Veterinary Hospital of the Federal Rural University of the Semi-arid (UFERSA), with a foul odor in the ear, excess of dark colored cerumen, erythema, itching and acute pain palpating the base of the left ear. Through anamnesis, physical examination and complementary tests such as radiography, the animal was diagnosed with chronic otitis. Then, we opted for the surgical treatment of total ablation of the auditory canal (TECA), which consists of the removal of the vertical and horizontal ear canal, associated with lateral osteotomy of the tympanic bulla. The surgical procedure was effective in the treatment of chronic otitis unresponsive to drug treatment previously performed in the last five years, done intermittently by the tutor.

Ablação total do conduto auditivo em cão com otite crônica / Total ablation of hearing conduct in dog with chronic otite

A otite é uma inflamação do canal auditivo que pode acometer o ouvido externo e médio, sendo sua patogenia dividida em fatores perpetuadores, predisponentes e primários. Os sinais clínicos mais comuns são eritema, dor a palpação, prurido e exsudação. Além do hitórico e anamnese, radiografia, otoscopia e biopsia podem auxiliar no diagnóstico. O tratamento inicial tem o objetivo de controlar os fatores perpetuadores, eliminar os fatores predisponentes e fazer o controle da causa base. Nos casos de otite externa crônica recidivante, estenose do canal auditivo, deformidades auriculares, pólipos e neoplasias, indica-se fazer o tratamento cirúrgico. O presente trabalho relata o caso de um canino sem raça definida, com treze anos de idade, atendido no Hospital Veterinário da Universidade Federal Rural do Semi-árido (UFERSA), apresentando odor fétido no pavilhão auricular, excesso de cerúmen de coloração escura, eritema, prurido e dor aguda a palpar-se a base do pavilhão auricular esquerdo. Através da anamnese, exame físico e dos exames complementares como a radiografia, o animal foi diagnosticado com otite crônica. Optouse, então, pelo tratamento cirúrgico de ablação total do conduto auditivo (TECA), que consiste na retirada do canal vertical e horizontal do ouvido, associado à osteotomia lateral da bula timpânica. O procedimento cirúrgico foi eficaz no tratamento da otite crônica não responsiva ao tratamento medicamentoso realizado previamente nos últimos cinco anos feito de forma intermitente pelo tutor.(AU)

Otitis is an inflammation of the ear canal that can affect the outer and middle ear, and its pathogenesis is divided into perpetuating, predisposing and primary factors. The most common clinical signs are erythema, pain on palpation, itching and oozing. In addition to the history and anamnesis, radiography, otoscopy and biopsy can assist in the diagnosis. The initial treatment aims to control the perpetuating factors, eliminate predisposing factors and control the underlying cause. In cases of recurrent chronic external otitis, stenosis of the ear canal, ear deformities, polyps and neoplasms, surgical treatment is indicated. The present work reports the case of a 13-year-old mixed breed canine, attended at the Veterinary Hospital of the Federal Rural University of the Semi-arid (UFERSA), with a foul odor in the ear, excess of dark colored cerumen, erythema, itching and acute pain palpating the base of the left ear. Through anamnesis, physical examination and complementary tests such as radiography, the animal was diagnosed with chronic otitis. Then, we opted for the surgical treatment of total ablation of the auditory canal (TECA), which consists of the removal of the vertical and horizontal ear canal, associated with lateral osteotomy of the tympanic bulla. The surgical procedure was effective in the treatment of chronic otitis unresponsive to drug treatment previously performed in the last five years, done intermittently by the tutor.(AU)

Celulite juvenil canina: relato de caso / Canine juvenile cellulitis: case report

A celulite juvenil, também descrita como dermatite e linfadenite granulomatosa estéril, é um distúrbio pouco frequente que acomete cães entre três semanas a quatro meses. Sua etiologia é incerta, entretanto, a hipótese mais recente sugere uma provável falha no sistema imune associada à administração de vacinas. Os sinais clínicos incluem eritema, edema, pápulas e pústulas especialmente em pálpebras, lábios e focinhos, podendo também acometer outros locais, além de linfonodomegalia e otite bilateral. O diagnóstico requer exame citológico e histopatológico das lesões e a terapia deve ser precoce e agressiva, visando a imunossupresão através do uso de altas doses de glicocorticóides. Foi atendido no Centro Médico Veterinário da São Judas Campus Unimonte, um filhote de Golden Retriver, apresentando sinais clínicos acima descritos. Foram realizados exames diagnósticos e imposto o tratamento preconizado. Diante à resposta positiva ao uso de glicocorticoide, a reação de hipersensibilidade imunomediada após a administração da vacina é uma hipótese para o desenvolvimento da celulite juvenil neste caso. O objetivo deste trabalho é relatar um caso de celulite juvenil em um cão, visando a importância do conhecimento dos aspectos clínicos, diagnósticos e terapêuticos afim de um bom prognóstico.

Juvenile cellulitis, also described as dermatitis and sterile granulomatous lymphadenitis, is an uncommon disorder that affects dogs between three weeks to four months. Its etiology is uncertain, however, the most recent hypothesis suggests a probable immunesystem failure associated with vaccine administration. Clinical signs include erythema, edema, papules and pustules, especially on the eyelids, lips and snouts, and may also affect other areas, in addition to lymph node enlargement and bilateral otitis. The diagnosis requires, apart from history and clinical signs, additional exams such as the cytological and histopathological method of the lesions and the therapy must be early and aggressive, aiming at immunosuppression through the use of high doses of glucocorticoids. A Golden Retriver puppy was seen at the Veterinary Medical Center of São Judas Campus Unimonte, showing the clinical signs described above. Diagnostic exams were carried out and the recommended treatment was followed. Due to the positive response to the use of glucocorticoids, the immune-mediated hypersensitivity reaction after administration of the vaccine is a hypothesis for the development of juvenile cellulitis in this case. The objective of this work is to report a case of juvenile cellulites in a dog, aiming at the importance of knowledge of clinical, diagnostic and therapeutic aspects in order to have a good prognosis.