Do Bulk-Fill Resin Composites Present More Susceptibility to Marginal Degradation in Different Clinical Scenarios? A Systematic Review and Meta-Analysis

Abstract Objective: To compare the marginal degradation (susceptibility to marginal adaptation and marginal discoloration) of composite restorations placed in class II and V cavities using conventional and bulk-fill resin composites. Material and Methods: This study was approved by PROSPERO database (#42020201596). PubMed, Scopus, Embase, Web of Science, Lilacs, Cochrane, Open Grey, Clinical Trials, and Rebec databases were searched by three independent investigators using MeSH terms, supplementary concepts, synonyms, and free keywords, based on the PICOS strategy (P, population: restoration in permanent teeth; I, intervention: bulk-fill resin composite; C, comparison: conventional resin composite; O, outcome: marginal discoloration and adaptation; and S, study design: randomized and non-randomized clinical trials). The risk of bias was evaluated according to the Cochrane Collaboration's tool, the meta-analyses by RevMan software, the certainty of evidence by the Grading of Recommendations Assessment, Development, and Evaluation, and the leave-one-out sensitivity test. The prevalence of successful events and the total number of restorations were used to calculate the risk difference at a confidence interval of 95%, according to a fixed-effect model. The heterogeneity was evaluated using the I2 index. Results: 16 from 10,780 studies were selected and included for qualitative and quantitative analysis. Two studies were considered as high risk of bias, one showing some concerns, and 13 as low risk of bias. Four meta-analyses evaluated the marginal adaptation and marginal discoloration in class II and V cavities, with a nonsignificant heterogeneity (I2 = 0%, p>0.05). The certainty of evidence was considered high, except for two subgroups of each outcome. Conclusion: There is evidence that composite restorations using conventional and bulk-fill resin composites present similar clinical performance related to marginal degradation (AU).

Efficacy and safety of Botulinum toxin A for improving esthetics in facial complex: A systematic review

Abstract Aim: To evaluate efficacy and safety of Botulinum toxinA for improving esthetics in the facial complex and correlating them to the dosage and side effects through a systematic review. Methods: A literature search was performed using PubMed, Medline, Web of Sciences, and Scopus databases. Quality of studies was appraised through the GRADE system. This review follows the 'Preferred reporting items for systematic review and meta-analysis protocols' (PRISMA-P) 2015 statement. Efficacy was analyzed through improvement rate and effect sizes. Graphical comparison of efficacy and ocular adverse effects (adverse effects around the eye) at various anatomical locations was made by calculating the average improvement rate and adverse events. Results: Twenty-five studies were included in this systematic review after application of the inclusion criteria. Moderate to severe cases in glabellar, lateral canthal, and forehead regions showed higher improvement rates between 20U to 50U, with an effect lasting up to 120 days. Gender and age seemed to have a direct effect on efficacy. Headaches were the most common adverse effect, followed by injection site bruising; all adverse effects resolved within 3-4 days. Conclusions: Treatment with Botulinum toxinA to enhance esthetics of facial complex is efficient and safe at all recommended dosages. Presence of complexing proteins influenced the efficacy of BoNT-A. undesirable muscular adverse effects around the eyes were more predominant when treating the glabellar region. There was no correlation found between the BoNT-A dosage and side effects, however, an increase in dosage did not always lead to an increase in efficacy.

Resumo Objetivo: Avaliar a eficácia e segurança da toxina botulínica-A para melhorar a estética no complexo facial e correlacioná-la com a dosagem e os efeitos secundários através de uma revisão sistemática. Métodos: Foi realizada uma pesquisa bibliográfica utilizando bases de dados PubMed, Medline, Web of Sciences, e Scopus. A qualidade dos estudos foi avaliada através do sistema GRADE. Esta revisão segue a declaração "Preferred reporting items for systematic review and meta-analysis protocols" (PRISMA-P) 2015. A eficácia foi analisada através da taxa de melhoria e da dimensão dos efeitos.A comparação gráfica da eficácia e dos efeitos adversos oftalmológicos (efeitos adversos em torno do olho) em vários locais anatômicos foi feita através do cálculo da taxa média de melhoria e dos eventos adversos. Resultados: Vinte e cinco estudos foram incluídos nesta revisão sistemática após a aplicação dos critérios de inclusão. Casos moderados a graves em regiões glabelares, canais laterais e testa mostraram taxas de melhoria mais elevadas entre 20U a 50U, com um efeito que durou até 120 dias. O sexo e a idade mostraram ter efeito direto na eficácia. As dores de cabeça foram o efeito adverso mais comum, seguido de hematomas no local da injecção; todos os efeitos adversos foram resolvidos em 3-4 dias. Conclusões: O tratamento com toxina botulínica-A para melhorar a estética do complexo facial é eficiente e seguro em todas as dosagens recomendadas. A presença de proteínas complexas influenciou a eficácia do BoNT-A. Os efeitos adversos musculares indesejáveis à volta dos olhos foram mais predominantes no tratamento da região glabelar. Não foi encontrada qualquer correlação entre a dosagem de BoNT-A e os efeitos secundários, contudo, um aumento da dosagem nem sempre levou a um aumento da eficácia.

The impact of Distinctive Root Canal Instrumentation Systems on Endotoxin Lessening from the Root Canal: A Systematic Review and Meta-Analysis

ABSTRACT Objective: To determine the impact of distinctive instrumentation systems of the root canals on the endotoxin lessening through the root canals. Material and Methods: From the electronic databases, MEDLINE, PubMed, Cochrane Library, Embase, ISI, Google Scholar have been used to perform a systematic literature review between 2015 and 2020. Therefore, a software program (Endnote X9) has been utilized for managing electronic titles. Searches were performed with keywords, "root canal," "instrumentation," "endotoxin," "root canal preparation," "biofilm" "endodontics," and "lipopolysaccharide." This systematic review has been conducted on the basis of the key consideration of the PRISMA Statement-Preferred Reporting Items for the Systematic Review and Meta-analysis. Results: Hence, 163 potentially important abstracts and research topics have been discovered by electronic searches and three studies (3 RCTs) have been included. According to the outputs, any statistically significant differences have been not found between the rotary files and reciprocation (SMD 0.51, 95% CI [0.11, 0.90], p=0.011) (I2 = 49.5%; p=0.138). Conclusion: Analyses indicated that instrumentation methods decreased the content of endotoxin from the root canals.

Hyalinization and Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis

Abstract Objective: To systematically review the hyalinization of experimental tooth movement in humans and animals. Material and Methods: The electronic databases of MEDLINE, PubMed, Cochrane Library, Embase, Institute for Scientific Information, and Google Scholar were searched for performing a systematic review of the related literature published until 2019. Moreover, Endnote X9 software was utilized to manage electronic titles. The searches were fulfilled using keywords of "hyalinization," "orthodontic tooth movement" OR "OTM" AND "periodontal ligament" OR "PDL," "molecular pathways," AND "mechanical cell." Therefore, this systematic review was conducted based on the key consideration of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Forces ranged between 2.3 and 50 CN had been applied. According to the research design, incisors had been included in two experiments, whereas maxillary molars had been displaced by tipping forces in another rat examination. However, a majority of investigations had stated that hyalinization had firstly appeared within the first 24 hours. Moreover, the amount of prostaglandin-end peroxide synthase 2 (PTGS2) had been positively related to force term and size utilizing Western blotching. As PTGS2 had been included in the prostaglandin E2 (PGE2) metabolism, the up-regulation of PTGS2 gene expression could be connected with that of PGE2 emission. Conclusion: Gene expression in connection with force term and size and also the first signalling pathways were recognized utilizing protein-protein interactions (PPIs).

Evaluating the Effectiveness of Orthognathic Surgery on the Pre-existing Temporomandibular Disorders in Patients with Malocclusion: A Systematic Review and Meta-analysis

Abstract Objective: To evaluate the prevalence of temporomandibular disorders (TMDs) for those patients with dentofacial deformities, who underwent orthognathic surgery, and the control group. It also identified whether orthognathic surgery had a positive or negative impact on TMD symptoms by comparing TMD patients, who underwent orthognathic surgery, and people did not experience this surgery. Finally, this systematic review and meta-analysis aimed to evaluate the effectiveness of orthognathic surgery on the pre-existing TMDs in malocclusion patients. Material and Methods: MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar have been utilized as the electronic databases for systematically reviewing the literature between 2001 and February 2019. Inclusion criteria were undergoing orthognathic surgery, patients with/without pre-existing TMDs, and physical disabilities. Results: A total of 669 abstracts and titles with potential relevance have been identified in the course of the manual and electronic searches. It has been found that five studies met our inclusion criteria for a systematic review. Temporomandibular disorders (TMDs) before orthognathic surgery in comparison to the controls (RR=0.02; 95% CI -0.08-0.13) and heterogeneity among the papers has been I2 = 42.86% (p=0.64). Conclusion: Malocclusion by orthognathic and orthodontics surgeries had a considerable rate of TMD compared to the controls.

Expression of osteoblastic phenotype in periodontal ligament fibroblasts cultured in three-dimensional collagen gel

Objective : To investigate the influence of a three-dimensional cell culture model on the expression of osteoblastic phenotype in human periodontal ligament fibroblast (hPDLF) cultures. Material and Methods : hPDLF were seeded on bi-dimensional (2D) and three-dimensional (3D) collagen type I (experimental groups) and and on a plastic coverslip (control) for up to 14 days. Cell viability and alkaline phosphatase (ALP) activity were performed. Also, cell morphology and immunolabeling for alkaline phosphatase (ALP) and osteopontin (OPN) were assessed by epifluorescence and confocal microscopy. The expression of osteogenic markers, including alkaline phosphatase, osteopontin, osteocalcin (OC), collagen I (COL I) and runt-related transcription factor 2 (RUNX2), were analyzed using real-time polymerase chain reaction (RT-PCR). Mineralized bone-like nodule formation was visualized by microscopy and calcium content was assessed quantitatively by alizarin red assay. Results : Experimental cultures produced an increase in cell proliferation. Immunolabeling for OPN and ALP in hPDLF were increased and ALP activity was inhibited by three-dimensional conditions. OPN and RUNX2 gene expression was significantly higher on 3D culture when compared with control surface. Moreover, ALP and COL I gene expression were significantly higher in three-dimensional collagen than in 2D cultures at 7 days. However, at 14 days, 3D cultures exhibited ALP and COL I gene expression significantly lower than the control, and the COL I gene expression was also significantly lower in 3D than in 2D cultures. Significant calcium mineralization was detected and quantified by alizarin red assay, and calcified nodule formation was not affected by tridimensionality. Conclusion : This study suggests that the 3D cultures are able to support hPDLF proliferation and favor the differentiation and mineralized matrix formation, which may be a potential periodontal regenerative therapy. .

Evaluation of scientific production in the field of Dentistry in Public Health from 1999 to 2009 / Avaliação da produção cientifica na área da Odontologia em Saúde Pública de 1999 a 2009

Introduction: Studies that analyze scientific production are essential to guide researchers. Aim: The purpose of this study was to analyze the profile of scientific production in the field of Dentistry in Public Health, by means of the abstracts published in the Annals of Sociedade Brasileira de Pesquisa Odontológica in the period from 1999 to 2009. Material and method: First, the reading of all the 22388 abstracts published in the annals of the Sociedade Brasileira de Pesquisa Odontológica from 1999 to 2009 was undertaken. The sample was 3061 abstract belonging to Public Health area. Result: There was growing participation of studies on Dentistry in Public Health with 113 studies having been inscribed in 1999 and 441 in 2009. There was a predominance of scientific studies in comparison with systematic reviews, meta-analyses, or case reports. In the classification of general nature of the research, 71.28% concerned studies with human beings. The greatest weight in the total number of researches with humans was in 2002, contributing with 79.79% of the total. With regard to the area of thematic domain, it was verified that studies involving Epidemiology were more frequent in all the years. When analyzing the institutional origin of studies, it was verified that in all the studied years, the public universities were responsible for the majority of scientific publications, 75.6% (n=2315). Conclusion: The studies on Dentistry in Public Health have grown significantly in the studied period of ten years. There was predominance of Epidemiological studies, and those of the in vivo and scientific research type. .

Introdução: Estudos que analizam a produção científica são fundamentais para orientar os pesquisadores. Objetivo: O objetivo deste estudo foi analisar o perfil da produção científica na área de Odontologia em Saúde Pública, por meio dos resumos publicados nos Anais da Sociedade Brasileira de Pesquisa Odontológica no período de 1999 a 2009. Material e método: Foram lidos 22388 resumos publicados nos anais da Sociedade Brasileira de Pesquisa Odontológica desde 1999 até 2009. A amostra foi de 3061 resumos pertencente a área da Saúde Pública. Resultado: A participação de estudos em Odontologia em Saúde Pública aumentou, com 113 estudos inscritos em 1999 e 441 em 2009. Houve predomínio de estudos científicos em comparação com revisões sistemáticas, meta-análises ou relatos de casos. Na classificação da natureza geral da pesquisa, 71,28% diziam respeito a pesquisa em seres humanos. O maior peso no número total de pesquisas com seres humanos foi no ano de 2002, contribuindo com 79,79% do total. No que diz respeito ao domínio temático, verificou-se que os estudos envolvendo Epidemiologia foram mais frequentes em todos os anos. Ao analisar a origem institucional dos estudos, verificou-se que em todos os anos estudados, as universidades públicas foram responsáveis pela maioria das publicações científicas, 75,6% (n=2315). Conclusão: Os estudos sobre Odontologia em Saúde Pública têm crescido significativamente no período estudado de dez anos. Houve predominância de estudos epidemiológicos, e as do tipo em estudos in vivo e pesquisas científicas. .

Eficácia do método de estimativa de idade de Lamendin / Efficacy of Lamendins dental age estimation method

Diante das dificuldades em estimar a idade de adultos e procurando se basear em pesquisas com evidência de qualidade, o presente trabalho objetivou verificar a eficácia do método de estimativa de idade de Lamendin por meio de uma revisão sistemática com metanálise e também aplicando a técnica a uma amostra brasileira. Para a metanálise, foram pesquisados estudos que tinham como objetivo mostrar a eficácia do método, comparando as idades cronológica e estimada da amostra. Foram excluídos os artigos com amostra histórica, os que modificaram a técnica, os que analisaram outros aspectos do método sem retratar sua eficácia e os que apresentaram a amostra em grupo único com indivíduos de menos de 25 anos de idade. Em seguida, a escala de qualidade de evidência QUADAS foi utilizada com modificações. A amostra final foi constituída de oito estudos. O trabalho de campo foi realizado numa amostra composta de 49 dentes provenientes de 26 crânios da coleção do Centro de Estudo e Pesquisa em Ciências Forenses do IML de Guarulhos-SP.

Os resultados mostraram que os estudos identificados descuidam de alguns aspectos metodológicos e que o método é ineficaz em idosos, mas que produz boas estimativas nos outros adultos. Nos brasileiros, adultos jovens mostraram as menores médias das diferenças Entretanto, existem discordâncias na literatura quanto à faixa etária em que o método funciona melhor. Diante do exposto, sugerimos que os estudos tenham mais rigor metodológico e que a técnica seja testada antes de ser usada numa determinada população, para que se possa constatar em qual faixa etária os resultados são mais precisos. Uma pesquisa com uma amostra brasileira maior também deve ser realizada, para que se possa verificar se sexo e tipo de dente influenciam os resultados.

Given the difficulties in estimating the age of adults and trying to rely on surveys of quality evidence, this study aimed to determine the effectiveness of Lamendins method of age estimation through a systematic review and meta-analysis and also by applying the technique to a Brazilian sample. For the meta-analysis, we researched studies that aimed to show the effectiveness of the method by comparing the chronological and estimated ages of the sample. We excluded studies with historical samples, those that changed the technique, the ones that analyzed other aspects of the method without presenting results on effectiveness and the ones that presented the sample in a single group with individuals less than 25years of age. Then, the quality evidence scale QUADAS was used with some modifications. The final sample consisted of eight studies. Fieldwork was conducted in a sample of 49 teeth from 26 skulls from the collection of the Center for Study and Research in Forensic Sciences from the IML Guarulhos-SP. The results showed that the studies identified could be methodologically careless and that the method is ineffective in the elderly, but produces good estimates for other adults. In Brazil, young adults showed the smallest mean errors.

However, there are discrepancies in the literature as to the age at which the method works best. We suggest that the studies have more methodological rigor and that the technique be tested before used in a given population, so it can be verified at what age the results are more accurate. A research with a larger Brazilian sample should be made, so it can be confirmed if sex and type of tooth influence the results.

Evidências científicas da associação entre fórmula infantil, fluorose e cárie dentária / Scientific evidence on infant formula, fluorosis and dental caries association

O consumo de fórmula infantil durante a primeira infância tem sido considerado um fator de risco em potencial para a fluorose e cárie dentária. O objetivo desta tese de doutorado foi avaliar, por meio de duas revisões sistemáticas e meta-análises, a relação entre o consumo de fórmula infantil e o risco de fluorose e cárie dentária. Para isso, foram consultadas oito bases de dados e listas de referências de artigos. A análise da relevância e abstração de dados foram realizadas em duplicata e independentemente por dois revisores. A qualidade dos estudos foi avaliada e os odds ratios, quando obtidos, foram combinados utilizando-se modelos de efeito aleatório. Na revisão sobre fluorose dentária, 41 de 969 publicações potencialmente elegíveis avaliaram o impacto da fórmula infantil no risco de fluorose dentária. Quatorze publicações não apresentaram os achados nos resultados. As restantes 27 publicações relataram os resultados em 19 estudos observacionais. Dezessete destes 19 estudos apresentaram odds ratio (OR) e entre eles o consumo de fórmula infantil esteve associado com uma maior prevalência de fluorose dentária na dentição permanente (OR global=1,8; intervalo de confiança de 95%=1,4-2,3). Observou-se significativa heterogeneidade entre os estudos (I-quadrado=66%) e evidência de viés de publicação (p=0,002). A metarregressão indicou que o odds ratio associado à fórmula infantil com a fluorose dentária aumentou em 5% para cada aumento de 0,1 ppm nos níveis de flúor da água de abastecimento (OR=1,05; intervalo de confiança de 95%=1,02-1,09). Na revisão sobre cárie dentária, 31 de 1.695 publicações elegíveis avaliaram o impacto da fórmula infantil no risco de cárie dentária. Duas publicações não apresentaram os achados nos resultados. As restantes 29 publicações relataram os resultados em 26 estudos observacionais. O consumo geral (OR global=1,7; intervalo de confiança de 95%=1,2-2,4) e noturno (OR global=2,0; intervalo de confiança de 95%=1,3-3,0) de fórmula...

Infant formula consumption during childhood has been considered a potential risk factor for enamel fluorosis and dental caries. The aim of this doctorate thesis was to evaluate, through two systematic reviews and meta-analysis, the relationship between infant formula consumption and the risk of enamel fluorosis and dental caries. Eight databases and reference list of articles were searched. Assessment of relevance and data abstraction were conducted in duplicate and independently by two reviewers. Study quality was assessed and odds ratios, when obtainable, were combined using a random-effects model. In the fluorosis systematic review, 41 out of 969 potentially eligible publications evaluated the impact of infant formula on enamel fluorosis risk. Fourteen publications did not report the findings in the results. The remaining 27 publications reported on 19 observational studies. Seventeen of these 19 studies reported odds ratio (OR) and among these infant formula consumption was associated with a higher prevalence of enamel fluorosis in the permanent dentition (summary OR=1.8; 95% confidence interval=1.4-2.3). There was significant heterogeneity among studies (I-squared=66%) and evidence of publication bias (p=0.002). A metaregression indicated that the odds ratios associating infant formula with enamel fluorosis increased by 5% for each 0.1 ppm increase in the reported levels of fluoride in the water supply (OR=1.05, 95% confidence interval=1.02-1.09). In the dental caries systematic review, 31 out of 1695 eligible publications evaluated the impact of infant formula on dental caries risk. Two publications did not report the findings in the results. The remaining 29 publications reported on 26 observational studies. General (summary OR=1.7; 95% confidence interval=1.2-2.4) and nocturnal (summary OR=2.0; 95% confidence interval=1.3-3.0) infant formula consumption was associated with a higher prevalence of caries in the primary dentition. There was significant...

Evidências científicas da associação entre fórmula infantil, fluorose e cárie dentária / Scientific evidence on infant formula, fluorosis and dental caries association

O consumo de fórmula infantil durante a primeira infância tem sido considerado um fator de risco em potencial para a fluorose e cárie dentária. O objetivo desta tese de doutorado foi avaliar, por meio de duas revisões sistemáticas e meta-análises, a relação entre o consumo de fórmula infantil e o risco de fluorose e cárie dentária. Para isso, foram consultadas oito bases de dados e listas de referências de artigos. A análise da relevância e abstração de dados foram realizadas em duplicata e independentemente por dois revisores. A qualidade dos estudos foi avaliada e os odds ratios, quando obtidos, foram combinados utilizando-se modelos de efeito aleatório. Na revisão sobre fluorose dentária, 41 de 969 publicações potencialmente elegíveis avaliaram o impacto da fórmula infantil no risco de fluorose dentária. Quatorze publicações não apresentaram os achados nos resultados. As restantes 27 publicações relataram os resultados em 19 estudos observacionais. Dezessete destes 19 estudos apresentaram odds ratio (OR) e entre eles o consumo de fórmula infantil esteve associado com uma maior prevalência de fluorose dentária na dentição permanente (OR global=1,8; intervalo de confiança de 95%=1,4-2,3). Observou-se significativa heterogeneidade entre os estudos (I-quadrado=66%) e evidência de viés de publicação (p=0,002). A metarregressão indicou que o odds ratio associado à fórmula infantil com a fluorose dentária aumentou em 5% para cada aumento de 0,1 ppm nos níveis de flúor da água de abastecimento (OR=1,05; intervalo de confiança de 95%=1,02-1,09). Na revisão sobre cárie dentária, 31 de 1.695 publicações elegíveis avaliaram o impacto da fórmula infantil no risco de cárie dentária. Duas publicações não apresentaram os achados nos resultados. As restantes 29 publicações relataram os resultados em 26 estudos observacionais. O consumo geral (OR global=1,7; intervalo de confiança de 95%=1,2-2,4) e noturno (OR global=2,0; intervalo de confiança de 95%=1,3-3,0) de fórmula...

Infant formula consumption during childhood has been considered a potential risk factor for enamel fluorosis and dental caries. The aim of this doctorate thesis was to evaluate, through two systematic reviews and meta-analysis, the relationship between infant formula consumption and the risk of enamel fluorosis and dental caries. Eight databases and reference list of articles were searched. Assessment of relevance and data abstraction were conducted in duplicate and independently by two reviewers. Study quality was assessed and odds ratios, when obtainable, were combined using a random-effects model. In the fluorosis systematic review, 41 out of 969 potentially eligible publications evaluated the impact of infant formula on enamel fluorosis risk. Fourteen publications did not report the findings in the results. The remaining 27 publications reported on 19 observational studies. Seventeen of these 19 studies reported odds ratio (OR) and among these infant formula consumption was associated with a higher prevalence of enamel fluorosis in the permanent dentition (summary OR=1.8; 95% confidence interval=1.4-2.3). There was significant heterogeneity among studies (I-squared=66%) and evidence of publication bias (p=0.002). A metaregression indicated that the odds ratios associating infant formula with enamel fluorosis increased by 5% for each 0.1 ppm increase in the reported levels of fluoride in the water supply (OR=1.05, 95% confidence interval=1.02-1.09). In the dental caries systematic review, 31 out of 1695 eligible publications evaluated the impact of infant formula on dental caries risk. Two publications did not report the findings in the results. The remaining 29 publications reported on 26 observational studies. General (summary OR=1.7; 95% confidence interval=1.2-2.4) and nocturnal (summary OR=2.0; 95% confidence interval=1.3-3.0) infant formula consumption was associated with a higher prevalence of caries in the primary dentition. There was significant...

Terapia periodontal de suporte: um fator-chave na promoção da saúde bucal / Supportive periodontal care: a key factor in the promotion of oral health

Estudos clínicos controlados mostraram de maneira definitiva o papel dos microorganismos na etilogia da doença periodontal. Infelizmente, o desafio microbiano é intenso e diário. Uma análise crítica dos estudos possibilitou estabelecer que os procedimentos mecânicos devem constituir a base do tratamento periodontal. Terapias adicionais, como o acesso cirúrgico e o uso de antiinflamatórios sistêmicos, trazem benefícios apenas em casos específicos. Devido a natureza crônica da doença periodontal, é fundamental uma conduta profissional centrada na manutenção periódica como um fator chave para seu controle em longo prazo.

Revisões sistemáticas da literatura / Systematic literature reviews

Há uma defasagem de treze anos entre a demonstração de efetividade de alguns tratamentos e sua utlização por médicos clínicos, decorrente da dificuldade para acessar informação e da deterioração do conhecimento pelo tempo. Porém, há métodos que facilitam o acesso à informação atualizada e a tomada de decisão na clínica ou na adiministração de serviços, tais como as revisões sistemáticas. Para suprir a ausência de literatura em português sobre o tema em revistas odontológicas e devido à existência de equívocos sobre este método de síntese da melhor evidência científica, sucintamente, apresentam-se conceitos métodos e aplicação das revisões sistemáticas para clínicos, estudantes, gestores e responsáveis por políticas públicas para melhor compreenderem e utilizarem esse instrumento de organização do conhecimento