Evaluation of the effectiveness and safety of single-operator cholangiopancreatoscopy with the SpyGlass™ system / Evaluación de la eficacia y seguridad de la colangiopancreatoscopia de un solo operador con el sistema SpyGlass®

Background and study aims The single-operator cholangiopancreatoscopy (SOCP) with the SpyGlass™ system is a endoscopy technique whose use has grown exponentially in recent years. The aims of this study were to evaluate the efficacy and safety of SOCP with SpyGlass™ and determine the factors related to the onset of adverse events (AEs). Patients and methods Retrospective study at a single tertiary institution with inclusion of all consecutive patients undergoing SOCP with SpyGlass™ from February-2009 to December-2021. No exclusion criteria were considered. A descriptive statistical analysis was performed. The factors associated with the existence of AE were analyzed using Chi-square and Student's t-test. Results A total of 95 cases were included. The most common indications were biliary strictures (BS) evaluation (66.3%) or treatment of difficult common bile duct stones (27.4%). Technical and clinical success was attained in 98.9%. Single-session stone clearance was obtained in 84%. The AE rate was 7.4%. To detect malignancy in BS, optical diagnosis presents a sensitivity and specificity of 100% and 91.2%, respectively; while histology results were 36.4% and 100% respectively. A previous endoscopic sphincterotomy was associated with a lower rate of AEs (2.4% vs 41.7%; p < 0.001). Conclusions SOCP with SpyGlass™ is a safe and effective technique to diagnose and treat pancreatobiliary pathology. The presence of sphincterotomy performed prior to the procedure could improve the technique's safety (AU)

Antecedentes y objetivos del estudio La colangiopancreatoscopia de un solo operador (SOCP) con el sistema SpyGlass® es una técnica endoscópica cuyo uso ha crecido exponencialmente durante los últimos años. Los objetivos de este estudio fueron evaluar la eficacia y seguridad de la SOPC con SpyGlass® y determinar los factores relacionados con la aparición de eventos adversos (EA). Pacientes y métodos Estudio retrospectivo realizado en un único centro terciario, con inclusión consecutiva de todos los pacientes sometidos a SOCP con SpyGlass® desde febrero de 2009 hasta diciembre de 2021. No hubo criterios de exclusión. Se realizó un análisis estadístico descriptivo. Los factores asociados a la aparición de EA se analizaron mediante χ2 y la prueba t de Student. Resultados Se incluyeron un total de 95 casos. Las indicaciones más frecuentes fueron la evaluación de estenosis biliares (EB) (66,3%) o el tratamiento de coledocolitiasis difícil (27,4%). El éxito técnico y clínico se logró en 98,9%. La extracción de todas las litiasis en una sola sesión se obtuvo en 84%. La tasa de EA fue de 7,4%. Para la detección de malignidad en EB, el diagnóstico óptico presenta una sensibilidad y especificidad de 100% y 91,2%, respectivamente; mientras que los resultados de la histología fueron 36,4 y 100%, respectivamente. La esfinterotomía endoscópica previa se asocia con una menor tasa de EA (2,4 vs. 41,7%; p < 0,001). Conclusiones La SOCP con SpyGlass® es una técnica segura y eficaz para diagnosticar y tratar la patología biliopancreática. La presencia de esfinterotomía previa al procedimiento podría mejorar la seguridad de la técnica (AU)

Effect of various dietary fructose concentrations on the gallstone formation process in mice / Efecto de diversas concentraciones de fructosa dietética en el proceso de formación de cálculos biliares en ratones

Background: little information is availaible on the effect of fructose on bile lipids. The first stage in the formation of gallstones corresponds tobiliary cholesterol crystallization, derived from the vesicular transporters. The aim of this study was to investigate the influence of consumingdiets with different fructose concentrations on serum lipids and their implications on gallstones formation. Methods: BALB/c mice divided into a control group as well as groups were treated with different fructose concentrations (10 %, 30 %, 50 % or70 %) for different periods (1, 2 or 5 months). Blood, liver and bile samples were obtained. In bile samples, cholesterol and phospholipids levelswere analyzed, and cholesterol transporters (vesicles and micelles) were separated by gel filtration chromatography. Results: treated animals showed: 1) increases in body weight similar to the control group; 2) a significant increase in plasma triglycerides only atvery high fructose concentrations; 3) a significant increase in total serum cholesterol in the treatment for 1 month; 4) no variations in HDL-cho-lesterol; 5) a significant increase in serum glucose only at very high fructose concentrations in the second month of treatment; 6) no differencesin the plasma alanine-aminotransferase activity; 7) a significant increase in liver triglyceride levels only at very high fructose concentrations; 8)no change in biliary lipid concentrations or in micellar and vesicular phospholipids.Conclusion: changes in plasma, liver and bile lipids were only observed at very high fructose concentrations diets. We conclude that fructoseapparently does not alter the gallstone formation process in our experimental model.(AU)

Introducción: se dispone de escasa información sobre el efecto de la fructosa sobre los lípidos biliares. La primera etapa en la formación decálculos biliares corresponde a la cristalización del colesterol biliar, derivado de los transportadores vesiculares. El objetivo de este estudio fueinvestigar la influencia del consumo de dietas con diferentes concentraciones de fructosa en los lípidos séricos y sus implicaciones en el procesode formación de cálculos biliares.Métodos: ratones BALB/c fueron tratados con diferentes concentraciones de fructosa (10 %, 30 %, 50 % o 70 %) durante diferentes períodos(1, 2 o 5 meses). Se obtuvieron muestras de sangre, hígado y bilis. En muestras de bilis se analizaron los niveles de colesterol y fosfolípidos, ylos transportadores de colesterol (vesículas y micelas) se separaron mediante cromatografía de filtración en gel.Resultados: los animales tratados mostraron: 1) aumentos en el peso corporal similares al grupo de control; 2) aumento significativo en lostriglicéridos plasmáticos sólo a concentraciones muy altas de fructosa; 3) aumento significativo del colesterol sérico total en el tratamientodurante 1 mes; 4) ninguna variación en los niveles de HDL-colesterol; 5) aumento significativo en glucosa sérica solo a concentraciones muyaltas de fructosa; 6) ninguna diferencia en la actividad de la alanina-aminotransferasa plasmática; 7) aumento significativo en los niveles detriglicéridos hepáticos sólo a concentraciones muy altas de fructosa; 8) ningún cambio en las concentraciones de lípidos biliares o en los fos-folípidos micelares y vesiculares.Conclusión: se observaron cambios en los lípidos plasmáticos, hígado y bilis sólo en dietas con concentraciones muy altas de fructosa. Con-cluimos que la fructosa aparentemente no altera el proceso de formación de cálculos biliares en nuestro modelo experimental.(AU)

Survey on initial management of acute pancreatitis in Latin America / Encuesta sobre el manejo inicial de la pancreatitis aguda en América Latina

Objective: The population of Latin America harbors the highest incidence of gallstones and acute biliary pancreatitis, yet little is known about the initial management of acute pancreatitis in this large geographic region. Participants and methods: We performed a post hoc analysis of responses from physicians based in Latin America to the international multidisciplinary survey on the initial management of acute pancreatitis. The questionnaire asked about management of patients during the first 72h after admission, related to fluid therapy, prescription of prophylactic antibiotics, feeding and nutrition, and timing of cholecystectomy. Adherence to clinical guidelines in this region was compared with the rest of the world. Results: The survey was completed by 358 participants from 19 Latin American countries (median age, 39 years [33–47]; women, 27.1%). The proportion of participants in Latin America vs. the rest of the world who chose non-compliant options with clinical guidelines were: prescription of fluid therapy rate other than moderate (42.2% vs 34.3%, P=.02); prescription of prophylactic antibiotics for severe (10.6% vs 18.0%, P=.002), necrotizing (28.5% vs 36.9%, P=.008), or systemic inflammatory response syndrome-associated (21.2% vs 30.6%, P=.002) acute pancreatitis; not starting an oral diet to patients with oral tolerance (77.9% vs 71.1%, P=.02); and delayed cholecystectomy (16.2% vs 33.8%, P<.001). Conclusions: Surveyed physicians in Latin America are less likely to prescribe antibiotics and to delay cholecystectomy when managing patients in the initial phase of acute pancreatitis compared to physicians in the rest of the world. Feeding and nutrition appear to require the greatest improvement. (AU)

Objetivo: La población de América Latina alberga la mayor incidencia de cálculos biliares y pancreatitis biliar aguda, sin embargo, poco se sabe sobre el manejo inicial de la pancreatitis aguda en esta extensa región geográfica. Participantes y métodos: Se realizó un análisis post hoc de las respuestas de los médicos de América Latina a la encuesta internacional multidisciplinar sobre el tratamiento inicial de la pancreatitis aguda. En el cuestionario se preguntaba por el manejo de los pacientes durante las primeras 72 h tras el ingreso, en relación con la fluidoterapia, la prescripción de antibióticos profilácticos, la alimentación y nutrición y el momento de la colecistectomía. La adherencia a las guías clínicas en esta región se comparó con la del resto del mundo. Resultados: La encuesta fue completada por 358 participantes de 19 países latinoamericanos (mediana de edad, 39 años [33-47]; mujeres, 27,1%). La proporción de participantes de América Latina frente al resto del mundo que eligieron opciones no conformes con las guías clínicas fueron: prescripción de fluidoterapia en casos distintos de los moderados (42,2 vs. 34,3%, p = 0,02); prescripción de antibióticos profilácticos en casos graves (10,6 vs. 18%, p = 0,002); necrotizante (28,5 vs. 36,9%, p = 0,008) o asociada al síndrome de respuesta inflamatoria sistémica (21,2 vs. 30,6%, p = 0,002); no inicio de dieta oral en pacientes con tolerancia oral (77,9 vs. 71,1%, p = 0,02); y retraso de la colecistectomía (16,2 vs. 33,8%, p < 0,001). Conclusiones: Los médicos encuestados en América Latina son menos propensos a prescribir antibióticos y a retrasar la colecistectomía cuando tratan a pacientes en la fase inicial de la pancreatitis aguda, en comparación con los médicos del resto del mundo. La alimentación y la nutrición parecen requerir las mayores mejoras. (AU)

One-step method laparoscopic bile tube detection and cholecystectomy in male athletes: a meta-analysis of gallbladder and chassis stones treatment

Objective: This meta-analysis evaluates the effectiveness and safety of the "one-step method" laparoscopic bile tube detection (LCBDE) combined with laparoscopic cholecystectomy (LC) in treating gallbladder and common bile duct stones (CBDS) specifically in male athletes. Methods: A thorough search was conducted in both Chinese and English medical databases to collect clinical randomized control trials (RCTs) that applied LCBDE combined with LC for treating gallbladder stones in male athletes. Key outcome measures included CBD stone clearance, operative times, stone residual rates, stone recurrence rates, postoperative complications, and length of hospital stay. Results: Twenty-one studies were included in this analysis. The rates of CBD stone clearance and stone residual were statistically similar in both the one-step and two-step methods. However, the one-step method demonstrated a significantly lower recurrence rate compared to the two-step method (OR = 0.37, 95%CI: 0.20, 0.69). The overall incidence of complications was notably lower in the one-step method (OR = 0.66, 95%CI: 0.52, 0.84), and the postoperative hospitalization period was shorter (WMD = -1.07 days, 95%CI: -2.00, -0.14). Conclusion: The "one-step method" of LCBDE combined with LC for treating gallbladder stones and CBDS in male athletes is as effective as the ERCP/EST sequential LC method. However, it has the added advantage of fewer postoperative complications and a quicker recovery period, making it a more ideal choice for male athletes who require a faster return to training and competition (AU)

Use a biodegradable stent in ERCP, it will never be forgotten

The easiest way to drain the bile duct or the main pancreatic duct by means of ERCP is the insertion of a plastic stent. Once cannulation has been achieved, which is generally the most complex and limiting step in ERCP, stent insertion is straightforward and rewarding. The main problem in benign pancreato-biliary conditions comes in the follow-up. Indications for biliary stent insertion in non-neoplastic diseases are common bile duct (CBD) stones that could not be completely extracted, benign strictures and leaks. In the pancreas stents are frequently inserted to prevent post-ERCP pancreatitis and for benign strictures and other less frequent conditions such as main pancreatic duct disruption. Currently in all centers more and more ERCPs are performed in patients without naive Papilla of Vater, generally for stent extraction or exchange. For example, in the recent study by Barakat and Banerjee, carried out in a tertiary care academic medical center, only 25% were index or initial ERCP, without previous sphincterotomy or stent, and subsequent procedures comprised the remaining 75 %. (AU)

Manejo mínimamente invasivo del síndrome de Mirizzi Va: Reporte de casos y revisión narrativa de la literatura / Minimally invasive management of Mirizzi syndrome Va: Case series and narrative review of the literature

Introducción El síndrome de Mirizzi (SM) es una patología infrecuente que es un reto para el cirujano. En el manejo quirúrgico, el abordaje abierto o el laparoscópico es un punto de discusión debido a la distorsión anatómica que se presenta. El objetivo de este estudio es analizar nuestra experiencia en el manejo laparoscópico de esta condición en el tipo Va. Materiales Realizamos un estudio descriptivo retrospectivo de pacientes con diagnóstico de SM tipo Va y tratados por abordaje laparoscópico, entre el 2014 y 2019, en dos centros de alto volumen de Bogotá, Colombia. Resultados Se evaluaron 1.073 pacientes que presentaron complicaciones por cálculos biliares, de los cuales 16 fueron diagnosticados con SM tipo Va. El 75% eran femeninos y el 25% masculinos; el 80% presentó ictericia y el 90% dolor abdominal. Doce pacientes presentaron fístula colecistoduodenal y cuatro fístula colecistocólica. Todos se manejaron de manera laparoscópica, en el 100% se logró realizar colecistectomía total y resección de fístula con cierre primario. La tasa de conversión fue del 0%, no hubo reingresos ni reintervención. El periodo de seguimiento fue de 18 meses. Conclusión El manejo laparoscópico en el SM es posible y seguro, teniendo en cuenta la experiencia del grupo quirúrgico y realizando una adecuada selección de los pacientes (AU)

Introduction Mirizzi's Syndrome (MS) is a rare pathology, known to be a challenge for the surgeon. In the surgical management, open approach vs laparoscopic is a topic of discussion due to anatomic variations. The aim of this study is to analyze our experience in the laparoscopic management of this condition in Type Va. Methods We made a descriptive retrospective study of patients diagnosed with MS type Va and treated by laparoscopic approach from 2014 to 2019, in two high volume centers of Bogotá, Colombia. Results 1073 patients who presented complications from gallstones were evaluated, of which 16 were diagnosed with MS type Va. 75% were females and 25% males; 80% presented jaundice and 90% abdominal pain; 12 patients showed cholecystoduodenal fistula and 4 cholecystocolic fistula. All patients underwent laparoscopic management, total cholecystectomy and fistula resection with primary closure was possible on a 100% of the patients. Conversion rate was 0%. The follow up was 18 months. Conclusion Laparoscopic management of MS is feasible and safe; the experience of the surgery group and selection of the patients is the key to a successful outcome (AU)

Quistes y hamartomas biliares, no siempre son asintomáticos / Biliary cysts and hamartomas are not always asymptomatic

In daily clinical practice, we can find consultation reasons and exploratoryfindings that can guide us to a certain pathology. However, to avoid mistakes,we must remember that there are fewer common diseases, which could leadto an unexpected final diagnosis.Hepatic cystic lesions are usually found incidentally, having a wide differentialdiagnosis. Among them are biliary cysts and hamartomas, rare lesions, butwith not inconsiderable importance, as we will see in the case that is exposedbelow. (AU)

En la práctica clínica habitual nos podemos encontrar motivos de consulta yhallazgos exploratorios que nos pueden guiar a una determinada patología.Sin embargo, para no caer en errores, debemos recordar que existen enfermedades menos habituales, que podrían llevarnos a un diagnóstico finalinesperado.Las lesiones quísticas hepáticas se hallan generalmente de forma incidental, teniendo un amplio diagnóstico diferencial. Entre ellas se encuentranlos quistes y hamartomas biliares, lesiones poco frecuentes, pero con unaimportancia no desdeñable, como veremos en el caso que se expone a continuación. (AU)

Long-term outcome of patients with biliary pancreatitis not undergoing cholecystectomy. A retrospective study

Background and objective: most acute pancreatitis cases are of biliary origin and cholecystectomy is recommended to prevent recurrence. However, some patients will never be referred for surgery. In this study, the long-term follow-up of this group of patients was reviewed.Methods: all new cases of biliary pancreatitis from January 2015 to December 2017 that did not undergo cholecystectomy were analyzed. Epidemiologic data and Charlson’s comorbidity index (CCI) were recorded. Recurrent episodes of pancreatitis or biliary events and mortality during the follow-up period were recorded.Results: a total of 104 patients were included in the study (30.4 % of all biliary pancreatitis cases) and the median age was 82 years (range, 27-96). Average CCI was 5 (range, 0-18) and the median follow-up period was 37 months (range, 1-70). A total of 41 patients (39.4 %) had gallstone-related complications. Twenty-three patients (22,1 %) had recurrent pancreatitis and 34 (32,7 %) developed biliary events. Twenty-five patients died during follow-up (24 %) but only in 6 (5,8 %) was death due to gallstone-related complications. Non-related mortality was 15.5 % in patients who refused surgery and 25 % in multiple-comorbidity patients.Conclusion: patients who did not undergo cholecystectomy were at high risk for biliary events and pancreatitis recurrence. Conservative treatment and surgical abstention should be individualized and reserved for patients with multiple comorbidities with a short life expectancy. (AU)

Empiema pleural secundario a cálculo biliar. Una complicación infrecuente / Pleural empyema secondary to gallstone. An infrequent complication

Mujer de 84 años que acude a Urgencias por presentar en la semana previa dolor en costado derecho de características pleuríticas asociado a fiebre tras haberse sometido a colecistectomía dos semanas antes. En la radiografía de tórax presenta derrame pleural, confirmándose en la tomografía computarizada de tórax con contraste y objetivándose derrame pleural loculado, así como una imagen compatible con litiasis biliar. Posteriormente se realiza toracocentesis diagnóstica en la que se obtienen resultados compatible con empiema. Se coloca drenaje pleural con instilación de uroquinasa y antibioterapia empírica, presentando buena evolución. Se establece el diagnóstico de empiema pleural secundario a cálculo biliar intraperitoneal (AU)

An 84-year-old woman come to the emergency department for presenting in the previous week pleuritic right flank pain associated with fever after having undergone cholecystectomy 2 weeks earlier. She presents pleural effusion in the chest X-ray, which was confirmed in the chest computered tomography with contrast, showing loculated pleural effusion, as well as an image compatible with biliary lithiasis. Subsequently, diagnostic thoracentesis is performed and the results were compatible with empyema. Pleural drainage is placed with urokinase instillation and empirical antibiotherapy, presenting good evolution. The diagnosis of pleural empyema secondary to intraperitoneal gallstone is established (AU)

Spontaneous proximal choledochoduodenal fistula, a rare complication of cholangiolithiasis

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Direct cholangioscopy-guided stone extraction / Extracción de piedras guiada por colangioscopia directa

No disponible