RESUMO
Heart infarction is one of the main causes of death in the human population.Assurance of a sufficient level of bioenergetic processes is very important for theheart after infarction. Mn2+ as well as thiamine pyrophosphate (TPP) are positiveeffectors of the pyruvate dehydrogenase complex (PDH) and the 2-oxoglutaratedehydrogenase complex (OGDH), both of which play a very important role in theKrebs cycle. Thus, we have established the effect of MnCl2 (10mg/kg) and TPP(20mg/kg) - 4 injections every 12 h - on the activity of PDH, OGDH, lactate dehydrogenase(LDH) and malate dehydrogenase (MDH). Additionally, we perform ananalysis of ECG to affirm the changes in the heart electrophysiology of healthy ratsafter MnCl2 and TPP treatment. We then analyzed changes in the activity of theseenzymes after experimental myocardial infarction in rats. We observed a decrease ofOGDH and MDH activity in rat hearts after infarction in comparison with shamoperatedrats. Treatment of healthy rats with MnCl2 caused an increase of OGDHactivity. Moreover both MnCl2 and TPP caused an increase of PDH activity and adecrease of MDH activity (TPP revealed a stronger effect). We found no changes inLDH activity. Electrocardiography data showed a slight shortening of the QT intervaland an enhanced heartbeat rate after treatment with MnCl2. TPP caused onlyelongation of the QT interval. In conclusion, application of MnCl2 enhanced theactivity of some very important enzymes in the respiration process (PDH andOGDH). This effect, connected with enhanced heartbeat and a slightly shortenedventricle relaxation, may have potential application during the key period of convalescencefollowing heart infarction (AU)
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