RESUMO
BACKGROUND: The objective of this study was to examine the B lymphocyte subsets in primary immunodeficiency that progress with antibody deficiency. METHODS: The patients' naive, memory, class-switched memory and non-switched memory B cells were compared with those of healthy individuals of matching ages using flow cytometry. RESULTS: A total of 67 patients with antibody deficiency and 28 healthy children of matching ages were included in the study. The median age of the patients was six years (min-max: 1-24) and 40 (59.7%) were male. The median age of the healthy controls was again six years (min-max: 1-17) and 12 (42.8%) were male. Patients with common variable immunodeficiency had higher relative counts of naive cells when compared with the control group; however, they were found to have lower relative counts of memory, relative and absolute counts of non-switched and relative counts of switched B lymphocytes (p = 0.001, 0.023, 0.003-0.003, 0.001, respectively). In patients with selective IgA deficiency, similar to patients with common variable immunodeficiency, the relative counts of naive cells were found to be higher, while the relative counts of memory and relative and absolute counts of non-switched B lymphocytes were found to be lower when compared with the control group (p = 0.011, 0.032, 0.006-0.009, respectively). Although patients with selective IgM deficiency had higher relative counts of naive B cells when compared with the control group, they had lower relative and absolute counts of non-switched B lymphocytes (p = 0.008-0.016). CONCLUSIONS: The B lymphocyte subsets of patients with selective IgA deficiency are largely similar to those of patients with common variable immunodeficiency. Both illness groups exhibit low levels of memory B cells
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Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Síndromes de Imunodeficiência/etiologia , Síndromes de Imunodeficiência/imunologia , Imunoglobulina G/análise , Imunoglobulina G/imunologia , Antígenos de Diferenciação de Linfócitos B/análise , Antígenos de Diferenciação de Linfócitos B/imunologia , Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/análise , Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia , Agamaglobulinemia/etiologia , Agamaglobulinemia/imunologia , Agamaglobulinemia/patologia , Deficiência de IgA/etiologia , Deficiência de IgA/imunologia , Deficiência de IgA/patologiaRESUMO
El autor realiza una actualización sobre conceptos como las reacciones inmunitarias, el fenómeno inflamatorio y la respuesta alérgica, tres situaciones profundamente interrelacionadas.Comienza con una breve descripción de la inflamación, acción inespecífica del organismo contra la agresión de múltiples agentes etiológicos de la inmunidad, un fenómeno que a diferencia de la inflamación es una respuesta específica del sistema inmunitario frente a sustancias extrañas y que -como característica especial- genera memoria, es decir, que cuando el sistema ha sido activado una vez, lo recuerda, de manera que ante un segundo estímulo la respuesta es más rápida e intensa.En este artículo, los protagonistas son el antígeno ofensor, el sistema o complejo HLA y los linfocitos B, primeros elementos celulares que inician la respuesta ante la provocación del antígeno sintetizando las inmunoglobulinas (AU)
