Erupción fija por luz solar, una serie de 13 casos en Bogotá, Colombia / Fixed Sunlight Eruption: A Series of 13 Cases in Bogotá, Columbia

Desde 1975 se han publicado algunos casos que asocian la radiación ultravioleta como un desencadenante de erupciones cutáneas fijas (erupción o exantema fijo por luz solar o síndrome de fotosensibilidad localizada de amplio espectro). Describimos los casos de 13 pacientes con esta dermatosis, 4 varones (30,8%) y 9 mujeres (69,2%), con edades comprendidas entre los 28 y los 56 años, atendidos en un centro de referencia en dermatología en Bogotá, Colombia. Las lesiones se localizaron en la cara interna de los muslos, los glúteos, la región poplítea, la axilar anterior y posterior y el dorso de los pies. La prueba de fotoprovocación logró la reproducción de las lesiones en todos los casos en las áreas afectadas y la histopatología reveló cambios similares a los descritos en los eritemas fijos por medicamentos. Esta enfermedad podría corresponder a un subtipo de erupción fija, aunque no se descarta que sea una dermatosis diferente con una patogenia común.(AU)

Few reports describing an association between UV radiation and fixed skin eruptions have been published since 1975. These reactions have received various names, including fixed sunlight eruption, fixed exanthema due to UV radiation, and broad-spectrum abnormal localized photosensitivity syndrome. We present a series of 13 patients (4 men [30.8%] and 9 women [69.2%]) aged between 28 and 56 years who were evaluated for fixed eruptions induced by UV radiation at a dermatology referral hospital in Bogotá, Colombia. The lesions were located on the inner thighs, buttocks, popliteal region, anterior and posterior axilla, and dorsum of the feet. Photoprovocation reproduced lesions in all the affected areas, and histopathology showed changes similar to those seen in fixed drug eruptions. While these UV-provoked reactions may be a type of fixed skin eruption, we cannot rule out that they may also be a distinct condition that simply shares a pathogenic mechanism with fixed eruptions.(AU)

[Translated article] Fixed Sunlight Eruption: A Series of 13 Cases in Bogotá, Colombia / Erupción fija por luz solar, una serie de 13 casos en Bogotá, Colombia

Desde 1975 se han publicado algunos casos que asocian la radiación ultravioleta como un desencadenante de erupciones cutáneas fijas (erupción o exantema fijo por luz solar o síndrome de fotosensibilidad localizada de amplio espectro). Describimos los casos de 13 pacientes con esta dermatosis, 4 varones (30,8%) y 9 mujeres (69,2%), con edades comprendidas entre los 28 y los 56 años, atendidos en un centro de referencia en dermatología en Bogotá, Colombia. Las lesiones se localizaron en la cara interna de los muslos, los glúteos, la región poplítea, la axilar anterior y posterior y el dorso de los pies. La prueba de fotoprovocación logró la reproducción de las lesiones en todos los casos en las áreas afectadas y la histopatología reveló cambios similares a los descritos en los eritemas fijos por medicamentos. Esta enfermedad podría corresponder a un subtipo de erupción fija, aunque no se descarta que sea una dermatosis diferente con una patogenia común.(AU)

Few reports describing an association between UV radiation and fixed skin eruptions have been published since 1975. These reactions have received various names, including fixed sunlight eruption, fixed exanthema due to UV radiation, and broad-spectrum abnormal localized photosensitivity syndrome. We present a series of 13 patients (4 men [30.8%] and 9 women [69.2%]) aged between 28 and 56 years who were evaluated for fixed eruptions induced by UV radiation at a dermatology referral hospital in Bogotá, Colombia. The lesions were located on the inner thighs, buttocks, popliteal region, anterior and posterior axilla, and dorsum of the feet. Photoprovocation reproduced lesions in all the affected areas, and histopathology showed changes similar to those seen in fixed drug eruptions. While these UV-provoked reactions may be a type of fixed skin eruption, we cannot rule out that they may also be a distinct condition that simply shares a pathogenic mechanism with fixed eruptions.(AU)

Pulsed magnetic field increases the effect of ultraviolet C radiation and thermal shock in aged yeasts / El campo magnético pulsado aumenta el efecto de la radiación ultravioleta C y el choque térmico en levaduras envejecidas

The study of the effects of the magnetic field (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the existing literature and the multiple effects described to date, there are few published articles that study the combined effect of MF with other physical agents during the cellular aging process. In this sense, the aim of this work is to study whether low frequency and intensity pulsed and sinusoidal MF exposure produce alterations in the cell killing effect of ultraviolet C (UVC) radiation and thermal shock during the chronological aging of S. cerevisiae. Yeast cells were exposed to 2.45 mT (50 Hz) sinusoidal MF and 1.5 mT (25 Hz) pulsed MF, during 40 days of aging, in combination with UVC radiation (50 J/m2) and/or thermal shock (52°C). Cell survival was evaluated by clonogenic assay. The exposure of yeast to pulsed MF produces an acceleration of aging, which is not observed in cells exposed to sinusoidal MF. The pulsed MF modifies the cellular response to damaging agents only in aged S. cerevisiae cells. In this sense, the pulsed MF applied increases the damage induced by UVC radiation and by thermal shock. In contrast, the sinusoidal MF used has no effect.(AU)

Comparative genomic analysis of Halomonas campaniensis wild-type and ultraviolet radiation-mutated strains reveal genomic differences associated with increased ectoine production / El análisis genómico comparativo de cepas mutadas por radiación ultravioleta y de tipo salvaje de Halomonas campaniensis revela diferencias genómicas asociadas con una mayor producción de ectoína

Ectoine is a natural amino acid derivative and one of the most widely used compatible solutes produced by Halomonas species that affects both cellular growth and osmotic equilibrium. The positive effects of UV mutagenesis on both biomass and ectoine content production in ectoine-producing strains have yet to be reported. In this study, the wild-type H. campaniensis strain XH26 (CCTCCM2019776) was subjected to UV mutagenesis to increase ectoine production. Eight rounds of mutagenesis were used to generate mutated XH26 strains with different UV-irradiation exposure times. Ectoine extract concentrations were then evaluated among all strains using high-performance liquid chromatography analysis, alongside whole genome sequencing with the PacBio RS II platform and comparison of the wild-type strain XH26 and the mutant strain G8-52 genomes. The mutant strain G8-52 (CCTCCM2019777) exhibited the highest cell growth rate and ectoine yields among mutated strains in comparison with strain XH26. Further, ectoine levels in the aforementioned strain significantly increased to 1.51 ± 0.01 g L−1 (0.65 g g−1 of cell dry weight), representing a twofold increase compared to wild-type cells (0.51 ± 0.01 g L−1) when grown in culture medium for ectoine accumulation. Concomitantly, electron microscopy revealed that mutated strain G8-52 cells were obviously shorter than wild-type strain XH26 cells. Moreover, strain G8-52 produced a relatively stable ectoine yield (1.50 g L−1) after 40 days of continuous subculture. Comparative genomics analysis suggested that strain XH26 harbored 24 mutations, including 10 nucleotide insertions, 10 nucleotide deletions, and unique single nucleotide polymorphisms. Notably, the genes orf00723 and orf02403 (lipA) of the wild-type strain mutated to davT and gabD in strain G8-52 that encoded for 4-aminobutyrate-2-oxoglutarate transaminase and NAD-dependent succinate-semialdehyde dehydrogenase, respectively. Consequently, these genes may be involved in increased ectoine yields. These results suggest that continuous multiple rounds of UV mutation represent a successful strategy for increasing ectoine production, and that the mutant strain G8-52 is suitable for large-scale fermentation applications.(AU)

Riesgos dermatológicos en trabajadores expuestos a radiación ultravioleta solar / Dermatological risks in workers exposed to solar ultraviolet radiation

Introducción: Actualmente la radiación ultravioleta (RUV) es un factor de riesgo importante en la salud de los tra-bajadores en un periodo a medio-largo plazo, ya que sus consecuencias pueden derivar en alteraciones cutáneas como el cáncer de piel.Método: El objetivo principal del trabajo es analizar la evidencia científica actual sobre las consecuencias dermato-lógicas de los trabajadores expuestos a la RUV de origen solar. Se ha llevado a cabo una revisión de alcance en dife-rentes bases de datos como Embase, LILACS, IBECS y Medline. Se seleccionaron 12 artículos por nivel de evidencia y criterios de inclusión-exclusión cuyo contenido se expuso en categorías que comprenden: actividades laborales con mayor riesgo y patologías dermatológicas más frecuentes.Resultados: Los trabajadores que realizan su actividad al aire libre son el grupo que presenta con mayor frecuencia patologías en la piel, junto con otros factores que pueden estar relacionados. La patología más frecuente referen-ciada en las publicaciones científicas analizadas es el cáncer de piel no melanocítico.Conclusiones: Es conveniente realizar un seguimiento especial a los grupos laborales analizados expuestos a RUV solar a lo largo del tiempo, así como continuar investigando la asociación entre patologías dermatológicas de ori-gen laboral, la exposición a RUV de origen solar y el estado de la capa de ozono, ya que son temáticas de interés global con gran impacto en la salud mundial. (AU)

Introduction: Currently, ultraviolet radiation (RUV) is an important risk factor in the health of workers in a medi-um-long term, since its consequences can lead to skin disorders such as skin cancer.Method: The main objective of the work is to analyze the current scientific evidence on the dermatological con-sequences of workers exposed to UVR of solar origin. A scoping review has been carried out in different databases such as Embase, LILACS, IBECS and Medline. 12 articles were selected by level of evidence and inclusion-exclusion criteria whose content was exposed in categories that include: work activities with greater risk and more frequent dermatological pathologies.Results: Workers who carry out their activities outdoors are the group that most frequently presents skin patholo-gies, along with other factors that may be related. The most frequent pathology referenced in the scientific publica-tions analyzed is non-melanocytic skin cancer.Conclusions: It is advisable to carry out a special follow-up of the analyzed labor groups exposed to solar UVR over time, as well as to continue investigating the association between dermatological pathologies of occupational ori-gin, exposure to solar UVR and the state of the ozone layer. since they are topics of global interest with great impact on world health. (AU)

Evaluación del efecto bactericida de la luz UV-LED sobre impresiones de alginato / Evaluation of the bactericidal effect of UV-LED light on alginate impressions

La cavidad oral alberga una gran cantidad de microorganismos que son potenciales patógenos, como el Citomegalovirus, Virus de la Hepatitis B (VHB), Virus de la Hepatitis C, Virus del Herpes simple tipos 1 y 2, Virus de la Inmunodeficiencia Humana, Mycobacterium tuberculosis y actualmente con la aparición del SARS COV-2 causante del covid-19, la comunidad odontológica debe tomar medidas más estrictas en sus protocolos de protección contra enfermedades. Para evaluar su eficacia germicida se aplicó la luz ultravioleta con distintos tiempos de exposición sobre las impresiones dentales de alginato, inmediatamente después de haber tomado la impresión, que al entrar en contacto con la cavidad oral del paciente está contaminada.Obteniendo como resultado una disminución en tamaño y cantidad de las colonias bacterianas en la mayoría de las muestras en las que se aplicó la luz UV LED a los 10 y 15 minutos de exposición.. Lo anterior, confirma su capacidad germicida gracias a su espectro ultravioleta de 245 nm que afecta la cadena de ADN y ARN de los microorganismos ya que es la longitud de onda de máxima absorción de su molécula, eliminando su capacidad reproductiva y de supervivencia. Las ventajas que ofrece como: su pequeño tamaño, fácil de manipular e instalar, que no requiere de un constante mantenimiento, bajo costo de adquisición; su luz de alta intensidad constante que no genera ningún aumento en la temperatura,lo hacen un excelente auxiliar desinfectante que puede incorporarse a las clínicas dentales. (AU)

The oral cavity houses a large number of microorganisms that are potential pathogens, such as cytomegalovirus, hepatitis B virus (HBV), hepatitis C virus, herpes simplex virus types 1 and 2, human immunodeficiency virus, mycobacterium tuberculosis and currently with the appearance of the SARS COV-2 that causes covid-19, the dental community must take stricter measures in its protection protocols against diseases. To evaluate its germicidal efficacy, ultraviolet light was applied with different exposure times on the alginate dental impressions, immediately after having taken the impression, which when it came into contact with the oral cavity of the patient is contaminated. As a result, a decrease in size and quantity of the bacterial colonies was observed in most of the samples in which the UV LED light was applied at 10 and 15 minutes of exposure. Some samples showed less bacterial growth even after 5 minutes of exposure. All this confirms its germicidal capacity thanks to its 245 nm ultraviolet spectrum that affects the DNA and RNA chain of microorganisms since it is the wavelength of maximum absorption of its molecule, eliminating its reproductive and survival capacity. The advantages it offers such as its small size, easy to handle and install, that it does not require constant maintenance, low acquisition cost; its constant high intensity light that does not generate any increase in temperature, makes it an excellent disinfectant auxiliary that can be incorporated into dental clinics. (AU)

The ABCD grading system in assessment of corneal cross-linking effect in keratoconus with different cone locations

Purpose: The aim of this study was to analyse the postoperative corneal cross-linking results of corneal parameters and the ABCD grading system, depending on the cone location.MethodsThirty eyes of 25 patients with keratoconus (KC), who received the corneal cross-linking (CXL) treatment, were included in this study. The exclusion criteria were: patients under 18 years of age, corneal pachymetry less than 400 μm, corneal scarring, history of ocular trauma, history of ocular surgery, and corneal pathology other than KC. Patients were examined at the baseline visit, and followed-up at three, six, and twelve months after the CXL. All patients underwent visual acuity and Scheimpflug tomography at all visits. Progression parameters, keratometries, and ABCD grading were compared between the visits. Patients were classified into two groups: central and paracentral cones group (within the central 5 mm corneal zone) and peripheral cones group (outside the central 5 mm corneal zone), based on X-Y coordinates of maximal keratometry (Kmax).ResultsParameter A remained relatively stable throughout the follow-up period in both groups. Parameter B and parameter C showed a significant increase in both groups postoperatively. Parameter D showed stability at the 6-month post-CXL visit in the peripheral KC group, while the central and paracentral KC group showed improvement at the 12-month post-CXL visit.ConclusionThere was no significant difference in the postoperative response between different cone locations in the ABCD grading system, when classifying according to the Kmax, except an earlier recovery of the parameter D in peripherally located cones. (AU)

Actinic cheilitis: Proposal of a clinical index

Background: Actinic cheilitis is a potentially malignant lesion most commonly found in the lower lip of individuals with chronic exposure to ultraviolet radiation. The aim of this study was to develop and to test a clinical indexthat can be used to assess the severity of actinic cheilitis.Material and Methods: The clinical index of actinic cheilitis was applied to 36 patients. An incisional biopsy wasobtained to grade oral epithelial dysplasias following the World Health Organization (WHO) and binary systems,and to evaluate their association with clinical characteristics by Fisher’s exact test (P<0.05). The accuracy of theindex was evaluated based on sensitivity, specificity, positive and negative predictive values, and receiver operating curve.Results: The blurring between the border of the lip and the skin was significantly associated with cases withoutdysplasia/mild epithelial dysplasia (P=0.041) and with low risk of malignancy (P=0.005). Ulcers and crusts weresignificantly associated with moderate/severe epithelial dysplasia (P=0.002 and P=0.012, respectively) and highrisk of malignancy (P=0.005 and P=0.045, respectively). Erosion showed a significant association only with highrisk cases of malignancy (P=0.024). The cut-off values of the diagnostic test showing the best performance were10 for the WHO grading system and 11 for the binary system.Conclusions: The index cut-offs with the highest accuracy were considered indicators for a biopsy. Erosion, ulceration and crusts were associated with more severe oral epithelial dysplasias. (AU)

Campaña de Protección Solar y Prevención del cáncer de piel en Farmacia Comunitaria, valoración de un nuevo servicio profesional / Sun Protection and Skin Cancer Prevention Campaign in Community Pharmacy, evaluation of a new professional service

JUSTIFICACIÓN: el cáncer de piel supone un problema de salud pública, cuya incidencia ha aumentado. El factor ambiental de mayor riesgo para ello es la exposición a la radiación ultravioleta. El farmacéutico comunitario (FC) es un profesional cualificado y formado para poder ayudar e indicar al paciente en la elección de su fotoprotector, así como, la galénica que mejor se adecúe a su tipo de piel. Además de realizar una tarea de prevención e información sobre los riesgos que implica la exposición solar.OBJETIVOS: •Valorar los conocimientos y el uso correcto de protectores solares por la población general. •Determinar el riesgo de padecer cáncer de piel (CP). •Valorar la necesidad de un servicio profesional farmacéutico (SPF) en prevención de CP.MATERIAL Y MÉTODOS: estudio multicéntrico descriptivo observacional transversal prospectivo a través de un cuestionario anónimo a toda la población mayor de 18 años que acudía a la farmacia comunitaria durante la semana del 14-19 de junio de 2021. En él, se recogieron datos demográficos, fototipo cutáneo, presencia de algún tipo de dermatosis, patología crónica, administración de algún medicamento fotosensibilizante, presencia de alguna lesión, criterios de derivación, factores de riesgo de CP, así como los conocimientos sobre protección solar.RESULTADOS: participaron un total de 17 FC realizando 147 encuestas, 73 % mujeres, el 41 % menor de 40 años. (AU)

Una mirada intercultural a la prevención del cáncer de piel en zonas altamente expuestas a rayos ultravioleta / Um olhar intercultural sobre a prevenção do câncer de pele em áreas altamente expostas aos raios ultravioleta / An intercultural look at the prevention of skin cancer in areas highly exposed to ultraviolet rays

Introducción: La incidencia del cáncer de piel sigue aumentando, por tal motivose desarrollan diversas políticas para fortalecer su prevención; pero, la morbimortalidadno disminuye. Objetivos: Describir y comprender las medidas de prevención del cáncerde piel desde una mirada intercultural. Metodología: Investigación cualitativa, diseñoetnográfico, en 13 residentes oriundos de Olmos, Perú, determinada por saturación. Losdatos recolectados por entrevista y observación participante, en un diario de campo, seprocesaron mediante análisis temático, y sometidos a triangulación de investigadores; secontó con aprobación de un comité de ética y el consentimiento informado de losparticipantes. Resultados: Tradiciones en la vestimenta para proteger la piel de los rayosultravioleta y remedios caseros utilizados para cuidar la piel. Conclusiones: Lospobladores, adoptaron ciertas tradiciones al vestirse y utilizaron plantas nativas como, “lahiguerilla” (Ricinus communis) y “la penca sábila” (Aloe vera), además mascarillas dearcilla para proteger su piel; sin embargo, algunas costumbres podrían afectar su salud,dejando entrever que urge fortalecer acciones educativas sobre fotoprotección, conenfoque intercultural, de modo que se valore y respete las prácticas positivas y semodifique aquellas nocivas, mediante la negociación, y se logre un cuidado seguro paradisminuir el riesgo de cáncer de piel.(AU)

Introduction: Worldwide, the incidence of skin cancer continues to increase,which is why various policies are developed to strengthen its prevention; however,morbidity and mortality does not decrease. Objectives: Describe and understand the mainprevention measures for skin cancer in areas highly exposed to ultraviolet rays from anintercultural perspective. Methodology: Qualitative research with ethnographic design, ina sample of 13 residents from Olmos, Peru, determined with the saturation andredundancy technique. The data were collected through the ethnographic interview andparticipant observation, recorded in a field diary, processed through thematic analysis,and subjected to triangulation by researchers, after approval of the project by a researchethics committee and informed consent of the researchers. participants. Results: a)Traditions in clothing to protect the skin from ultraviolet rays and b) Home remedies usedto care for the skin. Conclusions: The residents who participated in the study, adoptedcertain traditions when dressing and used native plants such as “castor” (Ricinuscommunis) and “aloe leaf” (Aloe vera), in addition to clay masks to protect their skin, considered very effective in preventing cancer; however, some beliefs and customs couldaffect your health; suggesting that it is urgent to strengthen educational actions onphotoprotection, with an intercultural approach, so that positive practices are valued andrespected and those that are harmful are modified, through negotiation, so that safe careis achieved to mitigate the effects of the ultraviolet rays on the skin.(AU)

Introdução: A incidência do câncer de pele continua aumentando, por isso váriaspolíticas são desenvolvidas para fortalecer sua prevenção; mas, morbidade e mortalidadenão diminuem. Objetivos: Descrever e compreender as medidas de prevenção do câncerde pele em uma perspectiva intercultural. Metodologia: Pesquisa qualitativa, desenhoetnográfico, em 13 residentes de Olmos, Peru, determinada por saturação. Os dadoscoletados por meio de entrevista e observação participante, em diário de campo, foramprocessados por meio de análise temática e submetidos à triangulação dos pesquisadores;foi aprovado por um comitê de ética e o consentimento informado dos participantes.Resultados: Tradições em roupas para proteger a pele dos raios ultravioleta e remédioscaseiros para cuidar da pele. Conclusões: Os colonos adotaram certas tradições ao sevestir e usar plantas nativas como “a figueira” (Ricinus communis) e “a folha de babosa”(Aloe vera), além de máscaras de argila para proteger a pele; Porém, alguns costumespodem afetar sua saúde, sugerindo que é urgente fortalecer ações educativas sobrefotoproteção, com enfoque intercultural, para que as práticas positivas sejam valorizadase respeitadas e as nocivas sejam modificadas, por meio da negociação, e o cuidado seguroseja alcançado. para diminuir o risco de câncer de pele.(AU)

Estudio de la dosis eritematosa mínima en una serie de urticaria solar / Study of Minimal Erythema Dose in a Series of Solar Urticaria

Antecedentes La dosis eritematosa mínima (DEM) reducida es una reacción anormal a la luz según el fototipo de piel y que se determina mediante fototest. La DEM es reducida o anormal en algunas fotodermatosis. Sin embargo, no hemos encontrado información sobre la DEM reducida en pacientes con urticaria solar (US), enfermedad que cursa con urticaria tras la exposición al sol. Objetivo Determinar la DEM en una serie de pacientes con US. Métodos Llevamos a cabo un estudio prospectivo de casos de US diagnosticados en nuestro departamento entre enero de 2007 y diciembre de 2017, a través de anamnesis o por provocación mediante exposición a la luz solar natural o a fuentes de luz artificial. De acuerdo con el protocolo del Grupo Español de Fotobiología, a las 24 horas se llevó a cabo la lectura del fototest en todos los pacientes. Se recopilaron las variables relativas al paciente (edad, sexo, fototipo), enfermedad (tiempo de evolución, espectro de activación) y otras relacionadas con la posible DEM reducida (autoanticuerpos, medicación fototóxica). Resultados Se estudiaron 25 pacientes, de los cuales, seis (24%) presentaron una DEM anormal, el 83% de ellos eran hombres, y el 50% mostraba el espectro de acción en el rango de la radiación UVB. Conclusión Hasta en una cuarta parte de los pacientes con US se puede observar la DEM anormal. Esta circunstancia podría tener implicaciones en la selección de los pacientes y en los protocolos para el tratamiento con fototerapia (AU)

Background Reduced minimal erythema dose (MED) is an abnormal erythematous reaction to light according to the skin phototype, which is determined by phototest. MED is reduced or abnormal in some photodermatoses. However, we have not found information about reduced MED in patients with solar urticarial (SU), a condition which causes hives after sun exposure. Objective To determine MED in a series of patients with SU. Methods We conducted a prospective study of SU cases diagnosed in our department between January 2007 and December 2017, either by anamnesis, provocation with natural sunlight or provocation with artificial light sources. In all patients, a phototest with reading at 24 h was performed according to the protocol of the Spanish Group of Photobiology. Variables related to the patient (age, sex, phototype), disease (time of evolution, action spectrum) and others related to possible reduced MED (autoantibodies, phototoxic medication) were collected. Results Twenty-five patients were studied. Six patients (24%) had abnormal MED. Eighty-three percent of patients with abnormal MED were men, and 50% had action spectrum in UVB. Conclusion Abnormal MED can be seen in up to a fourth of the patients with SU. This could have implications in the selection of patients and protocols for treatment with phototherapy (AU)

Lesiones malignas de la piel en trabajadores del sector pesquero: Revisión sistemática / Malignant Skin Neoplasms in Workers in the Fishing Industry: Systematic Review

OBJETIVO: Revisar la literatura científica relacionada con los efectos de la exposición ocupacional a factores de riesgo para neoplasias cutáneas en trabajadores del sector pesquero. MÉTODO: Análisis crítico de los trabajos recuperados mediante revisión sistemática en MEDLINE (PubMed), EMBASE, The Cochrane Library, Scopus, Web of Science y Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS). Se evaluó la calidad de los artículos seleccionados mediante el cuestionario STROBE. RESULTADOS: Al atribuir los criterios de inclusión y exclusión a la búsqueda, se aceptaron 11 estudios para su revisión. En 7 de ellos, se obtuvo una asociación estadísticamente significativa entre neoplasia cutánea y exposición ocupacional. CONCLUSIONES: Se observa una relación entre lesiones malignas y exposición a radiación ultravioleta en el ámbito laboral, no obstante, la existencia de posibles sesgos hace que los resultados deban de tomarse con precaución

OBJECTIVE: To review the scientific literature related to the effects of occupational exposure to risk factors for skin neoplasms in fishery workers. METHOD: Critical analysis of the papers recovered through systematic review from en MEDLINE (PubMed), EMBASE, The Cochrane Library, Scopus, Web of Science y Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS). STOROBE guidelines were followed to evaluate their quality. RESULTS: After attributing inclusion and exclusion criteria to the search, 11 articles were accepted for review and critical analysis. In 7 of them, a statistically significant association was obtained between skin neoplasia and occupational exposure in fishermen. CONCLUSIONS: Despite having found studies that were significant in terms of the relationship of malignant lesions and exposure to ultraviolet radiation in the workplace, some of them did not control possible biases, therefore the results should be taken with caution

Granuloma anular fotoinducido demostrado experimentalmente mediante fotoprovocación UVA / Photoinduced Granuloma Annulare Confirmed by Experimental Exposure to UVA Light

No disponible

Fitofotodermatitis. También la piel en la ciudad / Phytophotodermatitis. Also the skin in the city

No disponible

Cáncer de piel y alfabetización sobre UV: estudio en trabajadores al aire libre / Skin Cancer and UV Literacy - Outdoor Workers Study

No disponible

Dosis eritematosa mínima: correlación con el fototipo y método de medición en una muestra de población colombiana / Minimal Erythema Dose: Correlation with Fitzpatrick Skin Type and Concordance Between Methods of Erythema Assessment in a Patient Sample in Colombia

ANTECEDENTES Y OBJETIVO: La determinación de la dosis eritematosa mínima (DEM) es necesaria para el estudio de la fotosensibilidad cutánea, debe determinarse en cada población, dadas las diferencias genéticas y las metodologías utilizadas. El objetivo de este estudio fue determinar la DEM en población colombiana, su correlación con los fototipos y la concordancia de dos alternativas de medición. PACIENTES Y MÉTODOS: Estudio de corte trasversal que incluyó 113 personas en Bogotá (Colombia). Se determinó la DEM para UVA + UVB y UVA utilizando un simulador solar y para UVB de banda estrecha (UVBBE) con una cabina de fototerapia. La evaluación se realizó visualmente y por Mexameter MX(R)-18. RESULTADOS: La mediana de la DEM para UVA+UVB fue de 22 mJ/cm2 para fototipos I y II y de 33 y 43 mJ/cm2 para fototipos III y IV, respectivamente; para UVA fue de 22, 42, 86 y 100 J/cm2 y para UVBBE de 390, 550, 770 y 885 mJ/cm2 (fototiposI-IV, respectivamente). La correlación entre los fototipos y la DEM osciló entre 0,5 y 0,69. El nivel de correlación-concordancia de LIN entre el método visual y el Mexameter fue superior a 0,8 en todos los casos. CONCLUSIONES: Este estudio permitió conocer los valores de DEM para UVA + UVB, UVA y UVBBE para los diferentes fototipos en la población colombiana, y evidenció una correlación muy buena entre los métodos de medición evaluados y una correlación moderada a buena entre la DEM y los fototipos

BACKGROUND AND OBJECTIVE: The minimal erythema dose (MED), an essential measurement in studies of skin photosensitivity, requires establishing MED values for specific populations, given genetic variation. Different ways to assess erythema are also relevant. We aimed to determine MED values in a sample of Colombian patients and correlations between MED and Fitzpatrick skin type. We also studied concordance correlation between MEDs and two alternative ways to assess erythema. PATIENTS AND METHODS: Cross-sectional study of 113 individuals in Bogotá, Colombia. We used a solar simulator to measure UV-A radiation and combined UV-A and UV-B (UVA+UVB) radiation, o se podría suprimir este término porque UVA y UVB son términos conocidos for MED calculation. Narrowband UV-B (NBUVB) radiation was measured in a phototherapy cabin. Erythema was assessed visually and with a Mexameter MX 18 device. RESULTS: The median MEDs of UVA + UVB radiation were 22 mJ/cm2 for Fitzpatrick skin typesI andII, and 33 and 43 mJ/cm2, respectively, for typesIII andIV. The MEDs of UV-A radiation were 22, 42, 86, and 10 0J/cm2 for types I, II, III, and IV, respectively. The MEDs of NBUVB light were 390, 550, 770, and 885 mJ/cm2 for the 4 skin types. The correlation between MEDs and skin types ranged from 0.5 to 0.69. Lin's concordance correlation coefficients between visual and Mexameter assessments of erythema were greater than 0.8 in all cases. CONCLUSION: This study allowed us to understand MED values for UV-A, UVA + UVB, and NBUVB according to different skin types in the Colombian population. Concordance correlation coefficients between the different methods of erythema assessment were very good. Correlations between MEDs and skin types were moderate to good

Rescue of Escherichia coli cells from UV-induced death and filamentation by caspase-3 inhibitor

Escherichia coli cells have been observed earlier to display caspase-3-like protease activity (CLP) and undergo programmed cell death (PCD) when exposed to gamma rays. The presence of an irreversible caspase-3 inhibitor (Ac-DEVD-CMK) during irradiation was observed to increase cell survival. Since radiation is known to induce SOS response, the effect of a caspase-3 inhibitor on SOS response was studied in E. coli. UV, a well-known SOS inducer, was used in the current study. Cell filamentation in E. coli upon UV exposure was found to be inhibited by ninefold in the presence of a caspase-3 inhibitor. CLP activity was found to increase twofold in UV-exposed cells than in control (non-treated) cells. Further, bright fluorescing filaments were observed in UV-exposed E. coli cells treated with FITC-DEVD-FMK, a fluorescent dye tagged with an irreversible caspase-3 inhibitor (DEVD-FMK), indicating the presence of active CLP in these cells. Unlike caspase-3 inhibitor, a serine protease inhibitor, phenylmethanesulfonyl fluoride (PMSF), was not found to improve cell survival after UV treatment. Additionally, a SOS reporter system known as SIVET (selectable in vivo expression technology) assay was performed to reconfirm the inhibition of SOS induction in the presence of caspase-3 inhibitor. SIVET assay is used to quantify cells in which the SOS response has been induced leading to a scorable permanent selectable change in the cell. The SIVET induction frequency (calculated as the ratio of SIVET-induced cells to total viable cells) increased around tenfold in UV-exposed cultures. The induction frequency was found to decrease significantly to 51 from 80% in the cells pre-incubated with caspase-3 inhibitor. On the contrary, caspase-3 inhibitor failed to improve cell survival of E. coli ΔrecA and E. coli DM49 (SOS non-inducible) cells post UV treatment. Summing together, the results indicated a possible linkage of SOS response and the PCD process in E. coli. The findings also indicated that functional SOS pathway is required for CLP-like activity; however, the exact mechanism remains to be elucidated

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Desinfección ambiental por luz ultravioleta / No disponible

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Impact of an ultraviolet air sterilizer on cardiac surgery patients, a randomized clinical trial / Impacto de un esterilizador ultravioleta en pacientes de cirugía cardíaca: ensayo clínico aleatorizado

Background: Numerous studies have evaluated the use of ultraviolet-C devices for terminal disinfection in hospitals, however, to date there is little information about the device's final impact on patients. We investigated the effect of an ultraviolet air sterilizer (UVAS) on the clinical outcomes of cardiac surgery patients. Materials and methods: This random, prospective and non-interventional study included 1097 adult patients undergoing elective cardiac surgery: 522 stayed in an ICU room with UVAS (Medixair®) and 575 patients ICU room without UVAS and were used as a control. The primary outcome measure was to evaluate the effect of a UVAS on the overall prevalence of nosocomial infections in postoperative cardiac patients in ICUs. Results: No significant differences in ventilator-associated pneumonia (4.6% vs. 5.0%, p=0.77) and total infection (14.0% vs. 15.5%, p=0.45) rates were detected in patients with and without the UVAS. The length of stay in the intensive care unit and at the hospital was similar in both groups, UVAS (4.6 (8.2) days and 18.3 (5.5) days) and without UVAS (4.6 (7.3) days and 19.2 (18.6) days). The 30-day in-hospital mortality rate was 5.3%, no significant differences between groups were observed (p=0.053). Conclusion: Novel ultraviolet-C technology has not been shown to significantly reduce nosocomial infections or mortality rates in cardiac surgery patients

Introducción: Numerosos estudios han evaluado el uso de dispositivos ultravioleta C para la desinfección terminal en hospitales; sin embargo, hasta la fecha existen pocos datos sobre el impacto en los pacientes. Hemos evaluado el efecto de un esterilizador de aire ultravioleta (UVAS) sobre las variables clínicas de los pacientes operados de cirugía cardíaca. Materiales y métodos: Este estudio prospectivo, aleatorizado no intervencional incluyó 1.097 pacientes adultos intervenidos de cirugía cardíaca electiva: 522 ingresaron en una habitación de UCI con UVAS (Medixair®) y 575 pacientes en habitación de UCI sin UVAS se utilizaron como control. La variable principal medida fue el efecto del UVAS sobre la prevalencia global de infecciones en el postoperatorio de cirugía cardíaca en UCI. Resultados: No hubo diferencias significativas en la neumonía asociada a ventilación mecánica (4,6% vs. 5,0%, p=0,77) e índices totales de infección (14,0% vs. 15,5%, p=0,45) detectados en pacientes con y sin UVAS. La duración del ingreso en UCI y en el hospital fue similar en ambos grupos, UVAS (4,6 [8,2] días y 18,3 [5,5] días) y sin UVAS (4,6 [7,3] días y 19,2 [18,6] días). La mortalidad a 30 días hospitalaria fue del 5,3%, sin diferencias significativas entre los grupos (p=0,053). Conclusión: La nueva tecnología ultravioleta C no ha demostrado disminuir las infecciones nosocomiales ni la mortalidad en pacientes de cirugía cardíaca

Estudio transversal sobre la repercusión de la información educativa en los hábitos de fotoprotección tópica en estudiantes de medicina / A cross-sectional study of the impact of educational information on topical photoprotection habits in medical students

Objetivos: El cáncer cutáneo (melanoma y no melanoma) es el tumor más frecuente del ser humano, siendo el melanoma el más agresivo. Dado que la exposición a la radiación ultravioleta (UV) es el único factor etiológico modificable, la fotoprotección es una medida preventiva primordial. Con estos fundamentos, se realizó una investigación cuyo objetivo principal fue comparar tres grupos poblacionales con distintos niveles de conocimiento sobre fotoprotección para conocer si existen diferencias en hábitos de exposición solar y grado de concienciación de los efectos perjudiciales del sol sobre la piel. Material y métodos: Estudio observacional transversal realizado mediante una encuesta entre octubre y diciembre de 2015 a 317 universitarios españoles con edades entre 18 y 25años. Se emplearon medidas estadísticas descriptivas y el test de chi-cuadrado. Resultados: Se realizaron seis preguntas para evaluar los hábitos de exposición solar. Se detectaron diferencias significativas en dos de ellas: autoexamen periódico de lunares (p<0,001) y empleo de factor de protección adecuado (p=0,025). Respecto al nivel de conocimientos, se realizaron cinco preguntas, encontrándose diferencias en todos los casos (p<0,001). Conclusiones: Tener más conocimientos sobre los riesgos de la exposición solar solo mejoró dos de los seis hábitos cuestionados sobre exposición solar. Probablemente existen otros factores que influyen en esta conducta, como los factores estéticos o socioculturales. La prevención temprana del cáncer de piel es fundamental, y es necesario establecer programas de promoción de la salud que tengan en cuenta estos otros condicionantes

Objectives: Skin cancer (melanoma and non-melanoma) is the most common cancer in humans, with melanoma being the most aggressive. Due to the fact that ultraviolet (UV) radiation exposure is the only adjustable aetiological factor, UV protection is the essential preventive measure. Based on these grounds, a study was conducted in order to compare three population groups with different levels of knowledge about UV protection, as well as to determine any differences in sun exposure habits, and the level of awareness of the damaging effects of the sun on the skin. Materials and methods: An observational, cross-sectional study was conducted using a questionnaire survey of 317 Spanish university students aged 18-25years old, between October and December 2015. Descriptive statistics methods and Pearson's Chi-squared were used. Results: Six questions were used to evaluate the sun exposure habits. Significant differences were detected in two of them: mole self-assessment (P<.001) and the use of an appropriate sun protection factor (P=.025). Five questions were asked concerning the level of knowledge about UV protection, with differences (P<.001) being found in all cases. Conclusions: Despite having more knowledge about the risks of sun exposure in the medical dermatology students group, only two of the six habits questioned were improved. Other factors that could be involved are the aesthetic or sociocultural factors. The early prevention of skin cancer is essential, with health promotion programs needing to be established that take into account all these conditions