Efectos de una intervención nutricional asociada a entrenamiento concurrente en la composición corporal de hombres físicamente activos / Effects of a nutritional intervention associated with concurrent training on the body composition of physically active men

RESUMEN: La práctica regular de ejercicio físico es una de las estrategias que se utiliza para optimizar la composición corporal. Para esto, no siempre se considera una intervención nutricional como parte de un trabajo interdisciplinario. El objetivo de este estudio fue identificar los efectos de un programa de intervención nutricional asociada a un entrenamiento concurrente en la composición corporal evaluada a través de bioimpedancia eléctrica (BIA) en hombres físicamente activos. La intervención tuvo una duración de 6 meses, donde participaron 12 personas (23,4 ± 4,9 años). Durante los primeros 5 meses se aplicó una planificación alimentaria y de entrenamiento ajustado a las características individuales de cada uno de los participantes, al comienzo del 6º mes, fue eliminada la planificación alimentaria y sólo se mantuvo el entrenamiento, esto con el objetivo de analizar los posibles cambios de composición corporal de los participantes. Antes (previo al programa de intervención), durante (al final del mes 5) y posterior a la intervención (final del mes 6) se evaluó el tejido adiposo, muscular y la masa libre de grasa a través de bioimpedancia eléctrica (BIA). Los resultados muestran que el programa de entrenamiento con intervención nutricional generaron en los primeros 5 meses, una disminución del porcentaje de tejido adiposo (PRE= 16,20 ± 4,75; POST= 9,52 ± 3,70; p= 0,000; TE= 1,51) e índice de tejido adiposo (PRE= 5,34 ± 1,75; POST= 3,16 ± 1,34; p=0,001; TE=1,35), aumento del porcentaje de tejido muscular (PRE= 46,05 ± 3,02; POST= 49,90 ± 2,90; p=0,004; TE= -1,25) y aumento el índice muscular/adiposo (PRE= 2,53 ± 0,75; POST= 4,85 ± 2,64; p=0,005; TE= -1,15), efectos que se atenúan significativamente cuando la intervención nutricional fue retirada del programa de intervención (p>0.05). Se concluye que la intervención nutricional es un factor clave para generar efectos positivos en la optimización de la composición corporal independientemente del nivel de entrenamiento de las personas. Estos resultados evidencian la importancia de la realización de una planificación alimentaria individualizada, ejecutada por un profesional nutricionista en los cambios de la composición corporal en sujetos físicamente activos. Los resultados de este estudio podrían orientar la consideración de un profesional nutricionista a la hora de formar equipos transdisciplinarios con el fin de mejorar hábitos de alimentación y de composición corporal.

SUMMARY: The regular practice of a certain type of training is one of the strategies used to optimize body composition. Consequently, nutritional intervention is not always considered as part of interdisciplinary work. This study aimed to identify the effects of a nutritional intervention program associated with concurrent training on body composition, assessed through bioelectrical impedance (BIA) in physically active men. The intervention lasted 6 months, with the participation of 12 subjects (23.4 ± 4.9 years). During the first 5 months, food and training planning was applied, adjusted to the individual characteristics of each of the participants. At the beginning of the 6th month, food planning was eliminated and only training was maintained, to analyze the possible changes in body composition of the participants. Prior to (before the intervention program), during (at the end of month 5), and after the intervention (end of month 6), adipose tissue, muscle, and fat-free mass were evaluated through electrical bioimpedance (BIA). The results showed that in the first five months, this training program generated a decrease in the percentage of adipose tissue (PRE= 16.20 ± 4.75; POST= 9.52 ± 3.70; p= 0.000; ES= 1.51) and adipose tissue index (PRE= 5.34 ± 1.75; POST= 3.16 ± 1.34; p=0.001; ES=1.35), increase in the percentage of muscle tissue (PRE= 46.05 ± 3.02; POST= 49.90 ± 2.90; p=0.004; ES= -1.25) and increased muscle/fat index (PRE= 2.53 ± 0.75; POST = 4.85 ± 2.64, p=0.005, SE= -1.15). The above effects were significantly reduced when the nutritional intervention was withdrawn from the program (p>0.05). It is concluded that nutritional intervention is a key factor to generate positive effects in the optimization of body composition regardless of the level of training. These results show the importance of individualized food planning, carried out by a professional nutritionist with regard to changes in the body composition of physically active subjects. The results of this study could be useful for nutritionists when forming disciplinary teams to improve eating habits and body composition.

Framing the Latin American nutrition transition in a historical perspective, 1850 to the present / A constituição da transição nutricional latino-americana em uma perspectiva histórica, 1850 até o presente

Abstract This paper argues that many of the foundations and trends that led to the rise in obesity and other diet-related health problems in Latin America began to develop in the late nineteenth century. The tendency towards presentism in the nutrition transition literature provides a much abbreviated and limited history of changes in diet and weight. Whereas medical and nutrition researchers have tended to emphasize the recent onset of the crisis, a historical perspective suggests that increasingly global food sourcing prompted changes in foodways and a gradual "fattening" of Latin America. This paper also provides a methodological and historiographic exploration of how to historicize the nutrition transition, drawing on a diverse array of sources from pre-1980 to the present.

Resumo Este trabalho argumenta que fundamentos e tendências que levaram ao aumento da obesidade e de outros problemas de saúde relacionados à alimentação na América Latina começaram a surgir no final do século XIX. A propensão ao presentismo na literatura sobre transição nutricional produz uma história abreviada e limitada das mudanças em alimentação e peso. Embora pesquisadores médicos e nutricionistas enfatizem a recente instalação da crise, uma perspectiva histórica sugere que fontes alimentares crescentemente globalizadas resultaram em mudanças na alimentação e em gradual "aumento de gordura" na população latino-americana. O artigo propõe ainda a exploração metodológica e historiográfica de como historicizar a transição nutricional recorrendo a fontes pré-1980 até o momento.

Impacto del consumo de carne magra de cerdo sobre el riesgo cardiovascular / The impact of lean pork meat consumption on cardiovascular risk

Resumen Introducción: El valor nutritivo de las proteínas derivadas de la carne magra de cerdo ha cambiado ostensiblemente con la tecnificación en la producción y la posibilidad de obtener productos que conserven un alto valor nutritivo. No obstante, en nuestro medio su consumo se ha estigmatizado por un posible aumento de riesgo cardiovascular. Objetivo: Evaluar el impacto del consumo de la carne magra de cerdo sobre algunos parámetros antropométricos y bioquímicos de riesgo cardiovascular. Métodos: Se realizó un estudio de seguimiento a un grupo de 47 personas sanas que consumieron 200 gramos de carne magra de cerdo durante un periodo de ocho semanas, durante las cuales se valoraron parámetros bioquímicos, antropométricos, nutricionales y de riesgo cardiovascular. Resultados: Se observó que, tanto a las cuatro como a las ocho semanas, los niveles de colesterol LDL y triglicéridos no variaron. No obstante, los niveles de colesterol HDL y los micronutrientes zinc, hierro y vitamina B12 aumentaron en plasma luego de ocho semanas de consumo de carne magra de cerdo. De igual forma, marcadores metabólicos, como la adiponectina y el IGF-1, incrementaron luego de ocho semanas de consumo. Conclusiones: De acuerdo con estas observaciones la carne magra de cerdo puede mejorar el aporte de algunos micronutrientes y parámetros metabólicos sin que se haya evidenciado un efecto adverso sobre ciertos parámetros de riesgo cardiovascular en individuos sanos.

Abstract Introduction: The nutritional value of proteins derived from lean pork meat has essentially changed with the introduction of technology in the production and the possibility of obtaining products that retain a high nutritional value. However, its consumption has been stigmatised in this country due to a possible increase in cardiovascular risk. Objective: To evaluate the impact of consuming lean pork meat on some anthropometric and biochemical parameters of cardiovascular risk. Methods: A follow-up study was conducted on a population of 47 healthy subjects that consumed 200 grammes of lean pork meat for a period of 8 weeks. An evaluation was made of some biochemical, anthropometric, nutritional and cardiovascular risk parameters. Results: No changes were observed in the LDL-cholesterol or triglyceride levels. However, the plasma levels of HDL-cholesterol, as well as those of micronutrients such as zinc, iron and vitamin B12, increased after 8 weeks of consuming lean pork meat. Furthermore, metabolic markers, like adiponectin and IGF-1, also increased after eight weeks of consumption. Conclusions: According to these observations, lean pork meat may improve the supply of some micronutrients, as well as some metabolic parameters, with no evidence of any adverse effects on certain cardiovascular risk factors in healthy individuals.

Nutrición y sueño / Nutrition and sleep

La nutrición correcta es relevante para un buen sueño, conocidos son los beneficios del sueño en la fisiología metabólica y cognitiva; su papel en la genética y la inmunidad a lo largo de la vida. Se presenta a continuación cómo la nutrición podría contribuir por varios factores, tanto en los genes reloj y su papel en el ritmo circadiano y hormonal, así como en la formación de neurotransmisores relacionados con el sueño. También se menciona su papel en los cronotipos y varios alimentos que mejorarían nuestro sueño. Concluimos que es importante como medida de salud pública en nuestros pacientes en un contexto de vida agitada, con altas tasas de exceso de desnutrición, y evitando la automedicación con hipnóticos para lograr un buen sueño. Palabras clave: Crononutrición, genes del reloj, cronotipos, nutrientes, sueño.

The right nutrition is relevant for good sleep, the benefits of sleep on metabolic and cognitive physiology are well known, as is their role in genetics and immunity throughout life. We explore how nutrition could contribute through several factors, both in the clock genes and their role in circadian and hormonal rhythm, as well as through the formation of sleep-related neurotransmitters. Its role in chronotypes and various foods that would improve our sleep is also mentioned. We conclude that it is important to intervene nutrition as a public health measure in our patients, who have a hectic life context, with high rates of excess malnutrition, and thus avoiding self-medication with hypnotics to achieve a good sleep. Keywords: Timeline, clock genes, chronotypes, nutrients, sleep

Construcción del perfil profesional del nutricionista deportivo / Professional Profile Construction of the Sports Nutritionist

Las directrices más recientes de la Organización Mundial de la Salud (OMS) han actualizado las recomendaciones anteriores, publicadas en 2010, las cuales reafirman la importancia de practicar actividad física que incluya ejercicios aeróbicos y musculares de forma regular. Los beneficios para la salud se acumulan al hacer cualquier cantidad de actividad y se evidencian en personas de todas las edades y habilidades. Las investigaciones muestran que estos beneficios se extienden más allá del sector de la salud con impacto a nivel social, económico y ambiental. Ante este panorama, surgen una amplia gama de posibilidades para el ejercicio de la profesión del nutricionista dietista, especialmente en el área de la nutrición deportiva, la cual se encarga de la aplicación de principios nutricionales con el fin de mejorar el entrenamiento, la recuperación y el rendimiento deportivo no solo de los atletas de élite, sino también de la población físicamente activa. La nutrición deportiva es un campo de rápido crecimiento en muchos países del mundo, sin embargo, en algunos países de Latinoamérica hasta el momento de esta revisión, no se identificaron estándares de práctica para los profesionales en nutrición y dietética que deseen convertirse en nutricionistas deportivos. Por tanto, el propósito de este artículo es describir el rol del nutricionista deportivo en la promoción de la salud y el bienestar para la población general, destacando las competencias del profesional, y brindar información sobre los pasos a seguir para construir una carrera sólida(AU)

The most recent guidelines from the World Health Organization (WHO) have updated previous recommendations, published in 2010, which reaffirm the importance of practicing a physical activity that includes aerobic and muscular exercises regularly. The health benefits accrue from doing any amount of activity and are evident in people of all ages and abilities. Research shows that these benefits extend beyond the health sector with social, economic and environmental impact. Against this background, a wide range of possibilities arise for the exercise of the profession of dietician nutritionist, especially in the area of sports nutrition, which is responsible for the application of nutritional principles in order to improve training, recovery and sports performance not only of elite athletes but also of the physically active population. Sports nutrition is a rapidly growing field in many countries worldwide; however, in some Latin American countries at the time of this review, no practice standards have been identified for nutrition and dietetic professionals wishing to become sports nutritionists. Therefore, the purpose of this article is to describe the role of the sports nutritionist in promoting health and well-being for the general population, highlighting the competencies of the professional, and provide information on the steps to follow to build a solid career(AU)

Nivel de conocimiento del cuidador primario sobre complicaciones infecciosas en el paciente pediátrico con cáncer / Knowkedge level of the primary caregiver of infectious complicatons inpediatric cancer patients

INTRODUCCIÓN: Las complicaciones infecciosas como consecuencia del cáncer y como efectos secundarios del tratamiento, son una realidad latente que enfrentan los pacientes y cuidadores. La prevención de éstas dependerá, en gran medida, de los adecuados cuidados que se brinden, especialmente en el hogar. OBJETIVO: Evaluar el nivel de conocimiento del cuidador primario sobre las complicaciones infecciosas en el paciente pediátrico con cáncer del Hospital de Especialidades del Niño y la Mujer en la ciudad de Querétaro. METODOLOGÍA: Estudio cuantitativo de corte transversal y nivel descriptivo, se contó con una muestra por conveniencia de 60 cuidadores primarios de paciente pediátrico con cáncer. Se utilizó un instrumento elaborado por los autores,para estudiar el nivel de conocimiento del cuidador primario. El instrumento está integrado por cuatro indicadores de conocimiento en las áreas de: nutrición, higiene, medidas de prevención y conocimiento de infecciones. Fue validado por medio del Método Delphi y se midió la confiabilidad con la prueba estadística de mitades partidas de Guttman. RESULTADOS: El 65% de los cuidadores tienen un conocimiento regular.La variable de conocimiento de infección es la que se observa con mayor área de oportunidad al obtener una calificación deficiente. CONCLUSIÓN: Se encontraron áreas de oportunidad para mejorar el conocimiento, específicamente en las acciones a emprender para la prevención de las infecciones. Con una adecuada intervención educativa de enfermería se pueden mejorar los conocimientos adquiridos por los cuidadores y disminuir con esto la prevalencia de infecciones.

INTRODUCTION: Infectious complications as a consequence of cancer and as secondary effects of treatment, are a latent reality that patients and caregivers will have to face, since to a large extent, the prevention of these will depend on the adequate care provided, especially in the home. OBJECTIVE: To evaluate the level of knowledge of the primary caregiver about the infectious complications in the pediatric patient with cancer of the Hospital of Specialties of Children and Women in the city of Querétaro. METHODOLOGY: A cross-sectional, descriptive level quantitative study was carried out with a convenience sample of 60 primary caregivers of a pediatric patient with cancer, an instrument prepared by authors on purpose to study the level of knowledge of the primary caregiver, made up of four indicators of knowledge in the areas of: nutrition, hygiene, prevention measures and knowledge of infection data, the instrument was validated by means of the Delphi Method and reliability was measured with the Guttman split halves statistical test. RESULTS: 65% of the caregivers were with regular knowledge, the knowledge item of infection is the one that is observed with greater area of opportunity when obtaining a deficient qualification. CONCLUSION: areas of opportunity were found to improve knowledge, specifically in the actions to be undertaken for the prevention of infections, which with an adequate educational nursing intervention could improve knowledge.

Nurses' knowledge about regional foods, food & nutritional safety / Conocimiento de las enfermeras sobre seguridad regional de alimentos, alimentos y nutrición / Conhecimento dos enfermeiros sobre alimentos regionais, segurança alimentar e nutricional

ABSTRACT Objectives: to analyze the knowledge of nurses working in Primary Health Care Units about regional foods, food & nutritional safety. Methods: a cross-sectional study conducted with 71 nurses working in health care units in the city of Fortaleza, Ceará. Data were obtained through administration of two questionnaires, subsequently analyzed through statistical tests. Results: a satisfactory level of knowledge was found for most nurses, and it was evident that those with graduate degrees had greater knowledge about 'regional food basics' (p=0,014) and 'frequency of use of regional foods' (p=0,014); the age of the professionals had an inversely proportional relationship with the knowledge about the 'concept of food & nutritional safety' (p=0,009). Conclusions: nurses had satisfactory knowledge about the themes addressed, and professionals should be encouraged to improve their knowledge and instruct families on the importance of a diet based on regional foods.

RESUMEN Objetivos: analizar el conocimiento de las enfermeras que trabajan en las unidades de atención primaria de salud sobre el tema Alimentos regionales, seguridad alimentaria y nutrición. Métodos: estudio transversal realizado con 71 enfermeras que trabajan en unidades de salud en la ciudad de Fortaleza, Ceará. Los datos se obtuvieron de la aplicación de dos cuestionarios y posteriormente se analizaron a partir de pruebas estadísticas. Resultados: se observó un nivel de conocimiento satisfactorio en la mayoría de las enfermeras, lo que demuestra que aquellos con estudios de posgrado tenían un mejor conocimiento sobre los "conceptos básicos de los alimentos regionales" (p=0,014) y la "frecuencia de uso de los alimentos regionales" (p=0,014); y que la edad de los profesionales presentaba una relación inversamente proporcional con el conocimiento sobre el 'concepto de seguridad alimentaria y nutricional' (p=0,009). Conclusiones: las enfermeras presentaron un conocimiento satisfactorio sobre los temas abordados, y se debe alentar a los profesionales a mejorar su conocimiento y guiar a las familias sobre la importancia de una dieta basada en alimentos regionales.

RESUMO Objetivos: analisar o conhecimento de enfermeiros atuantes em Unidades de Atenção Primária à Saúde acerca das temáticas Alimentos Regionais, Segurança Alimentar e Nutricional. Métodos: estudo transversal, realizado com 71 enfermeiros atuantes em unidades de saúde do município de Fortaleza, Ceará. Os dados foram obtidos a partir da aplicação de dois questionários e posteriormente analisados a partir de testes estatísticos. Resultados: observou-se satisfatório nível de conhecimento na maioria dos enfermeiros, ficando evidenciado que aqueles que fizeram pós-graduação apresentaram melhor conhecimento acerca dos 'conceitos básicos de alimentos regionais' (p=0,014) e 'frequência da utilização dos alimentos regionais' (p=0,014); e que a idade dos profissionais apresentou relação inversamente proporcional com o conhecimento sobre o 'conceito de segurança alimentar e nutricional' (p=0,009). Conclusões: os enfermeiros apresentaram conhecimento satisfatório acerca das temáticas abordadas, devendo-se estimular os profissionais a aprimorarem seus conhecimentos e a orientarem famílias acerca da importância de uma alimentação baseada nos alimentos regionais.

Analysis of the differences between the prescribed and the administered diet to preterm infants using an electronic too / Análise das diferenças entre a dieta prescrita e a dieta administrada aos recém-nascidos pré-termo usando um instrumento eletrônico

ABSTRACT Objective: To create an electronic instrument in order to analyze the adequacy of the preterm infants' nutritional therapy, checking the difference between the prescribed and the administered diet. Methods: A prospective and observational study on newborns with birthweight ≤1,500g and/or gestational age ≤32 weeks, without congenital malformations. The electronic instrument was developed based on Microsoft Excel 2010 spreadsheets and aimed at automatically calculating body weight gain, calories and macronutrients received daily by each patient from parenteral nutrition, intravenous hydration and enteral feedings. The weekly means of each nutrient were used to compare the prescribed and administered diets. Results: To evaluate the instrument, 60 newborns with a birth weight of 1,289±305 g and a gestational age of 30±2 weeks were included. Of them, 9.6% had restricted growth at birth and 55% at discharge. The median length of stay was 45±17 days. There were significant differences between prescribed and administered diet for all of the macronutrients and for total calories in the first three weeks. The lipid was the macronutrient with the greatest percentage error in the first week of life. Conclusions: The use of a computational routine was important to verify differences between the prescribed and the administered diet. This analysis is necessary to minimize calculation errors and to speed up health providers' decisions about the nutritional approach, which can contribute to patients' safety and to good nutritional practice. Very low birth weight infants are extremely vulnerable to nutritional deficiencies and any reduction in macronutrients they receive may be harmful to achieve satisfactory growth.

RESUMO Objetivo: Elaborar um instrumento eletrônico para análise da adequação da terapia nutricional dos recém-nascidos pré-termo, verificando a diferença entre a dieta prescrita e a administrada. Métodos: Estudo observacional prospectivo em recém-nascidos com peso de nascimento ≤1.500 g e/ou idade gestacional ≤32 semanas, sem malformações congênitas. O instrumento eletrônico foi desenvolvido com base em planilhas do Microsoft Excel 2010 para calcular automaticamente ganho de peso corporal, calorias e macronutrientes diariamente recebidos pelos pacientes por meio de dietas parenteral e enteral. Para comparar a dieta prescrita e a administrada, foram utilizados os resultados das médias semanais. Resultados: Para avaliar o instrumento, foram incluídos 60 recém-nascidos com peso de nascimento de 1.289±305 g e idade gestacional de 30±2 semanas. Destes, 9,6% apresentavam restrição de crescimento no nascimento e 55% no momento da alta. A média de internação foi de 45±17 dias. Foram verificadas diferenças significativas entre a dieta prescrita e a administrada para todos os macronutrientes e calorias totais nas três primeiras semanas. O lipídeo foi o macronutriente com o maior erro percentual na primeira semana. Conclusões: O emprego de uma rotina computacional foi importante para verificar discrepâncias entre a dieta prescrita e a administrada. Essa análise é necessária para minimizar erros de cálculo e agilizar as decisões da equipe de saúde acerca da abordagem nutricional, podendo contribuir para a segurança do paciente e para a boa prática nutricional. Os recém-nascidos de muito baixo peso são extremamente vulneráveis às deficiências nutricionais e qualquer redução nos macronutrientes recebidos pode ser deletéria para o crescimento satisfatório.

Mortalidad por desnutrición en el adulto mayor, Colombia, 2014-2016 / Mortality due to malnutrition in older adults, Colombia, 2014-2016

Introducción. En el contexto de la salud pública y la nutrición, las personas mayores se consideran un colectivo vulnerable. Los programas de atención en salud dan prioridad a los hábitos alimentarios y a la vigilancia del estado nutricional para mejorar su pronóstico vital. Objetivo. Estimar los casos de muerte por desnutrición de la población mayor de 65 años en Colombia entre el 2014 y el 2016, para contribuir al análisis y la toma de decisiones en salud encaminadas a mejorar la situación nutricional de esta población. Materiales y métodos. Se trata de un estudio descriptivo y retrospectivo en el cual se analizaron los certificados de defunción de los años 2014 a 2016, cuya causa básica de muerte fuesen las deficiencias y anemias nutricionales. Se estimaron las tasas de mortalidad por sexo y departamento de residencia, y las frecuencias de distribución según las variables demográficas. Resultados. Las defunciones por desnutrición en Colombia para el adulto mayor en el periodo de estudio, fueron 3.275 (0,5 % del total de muertes). La tasa de mortalidad varió entre 5,4 y 108,3 por cada 100.000 adultos mayores. La mayor mortalidad se presentó en los mayores de 80 años, especialmente en hombres. Conclusión. La desnutrición proteico-calórica en los adultos mayores es la causa más frecuente de muerte por desnutrición, seguida de las anemias nutricionales. La mayor mortalidad se presentó en el grupo de edad de mayores de 80 años, y en los departamentos de Amazonas, Guainía y Vaupés, los cuales tienen las mayores tasas para todos los grupos de edad.

Introduction: Older people are positioned within the context of public health and nutrition as a vulnerable group. The priorities of the attention programs focus on eating habits and monitoring their nutritional status to improve their vital prognosis. Objective: To estimate the cases of death due to malnutrition of the population over 65 years old in Colombia for 2014 to 2016 to contribute to the analysis and decision-making in health to improve the nutritional situation of this population. Materials and methods: A retrospective descriptive study was carried out analizing death certificates from 2014 to 2016, whose basic cause of death was nutritional deficiencies and anemias. Mortality rates were estimated by sex and department of residence, and distribution frequencies were built based on demographic variables. Results: There were 3,275 deaths due to malnutrition in Colombia for the elderly in the study period (0.5% of total deaths). The mortality rate varied between 5.4 and 108.3 per 100,000 older adults. The highest mortality occurred in those over 80 years of age, especially in men. Conclusion: Caloric protein malnutrition in older adults is the most frequent cause of death due to malnutrition, followed by nutritional anemias. The highest mortality occurs in the age group over 80 years of age and the Amazonas, Guainía and Vaupés departments have the highest rates for all age groups.

Aspectos nutricionales de las enfermedades respiratorias crónicas de la infancia / Nutritional aspects of chronic respiratory diseases of childhood

Chronic respiratory diseases compromise oxygenation to a variable degree and cause problems in the use of nutrients, the generation of energy and the use of it by different tissues and organs, with potential damage to respiratory function and non-respiratory systems. The available evidence indicates that both the available energy and some micronutrients, particularly with antioxidant activity, during pregnancy, are key for an adequate lung development and therefore an adequate pulmonary function in preterm infants, infants and older children, particularly if they attend bronchopulmonary dysplasia. However, both maternal and fetal malnutrition, as well as deficiencies of certain nutrients and the presence of overweight or obesity in the child, would influence the development of asthma in childhood. With regard to nutritional assistance, correction of nutritional deficit as well as micronutrients are essential in the treatment of diseases such as bronchopulmonary dysplasia, bronchiolitis obliterans and asthma. This review aims to establish how nutrition determines the development, evolution and prognosis of these pathologies and the need to consider nutritional assistance in the comprehensive care of these patients.

Las enfermedades respiratorias crónicas comprometen la oxigenación en grado variable y ocasionan problemas en el uso de los nutrientes, la generación de energía y la utilización de ésta por los distintos tejidos y órganos, con potencial daño en la función respiratoria y en los sistemas no respiratorios. La evidencia disponible señala que tanto la energía disponible y algunos micronutrientes, particularmente con actividad antioxidante, durante la gestación, son claves para un adecuado desarrollo pulmonar y por lo tanto una adecuada función pulmonar en prematuros, lactantes y niños mayores, en particular si cursan con displasia broncopulmonar. Sin embargo tanto la desnutrición materna y fetal, como las deficiencias de ciertos nutrientes y la presencia de sobrepeso u obesidad en el niño, influirían en el desarrollo de asma en la infancia. En lo referente a la asistencia nutricional, la corrección del déficit nutricional así como de micronutrientes, es indispensable en el tratamiento de enfermedades como la displasia broncopulmonar, la bronquiolitis obliterante y el asma. Esta revisión pretende establecer cómo la nutrición determina el desarrollo, evolución y pronóstico de estas patologías y la necesidad de considerar la asistencia nutricional en la atención integral de estos pacientes.

Feeding difficulties and eating disorders in pediatric patients with cancer / Trastornos y dificultades en la alimentación en pacientes pediátricos con cáncer

Abstract Background Feeding difficulties and disorders are a common problem in the pediatric population, which involve a series of deficient behaviors about nutrition processes that can adversely affect psychomotor, psychosocial, and physical development of children. This study aimed to describe the frequency of feeding difficulties or disorders in pediatric patients with cancer. Methods A prospective study which included 125 children from 1-19 years treated at the Department of Oncology of the Instituto Nacional de Pediatría, Mexico City, was conducted. The diagnosis of eating disorders and feeding difficulties was determined during the first 48 h since admission, and the age of the patient influenced the type of disorder and feeding difficulties. Results Children older than 11 years presented more frequently an intense resistance of feeding because of discomfort pain (fear of feeding) than younger children (11.4 ± 4.7 vs. 7.4 ± 4.9, p ≤ 0.001). The most frequent alteration associated with malnutrition was loss of appetite (odds ratio [OR]: 8.8, confidence interval [CI] 95% 2.9-26.9, p<0.001), followed by fear of feeding (OR: 3.14, CI 95% 1.24-7.9, p=0.015), and the organic causes showed the highest risk for malnutrition (OR: 3.1, CI 95% 0.98-9.7, p=0.054). Conclusions Over 90% of the studied population demonstrated at least one eating disorder or feeding difficulty. The principal effect is inadequate nutritional intake due to limited appetite and fear of feeding, which can result in undernutrition. For this reason, the identification of alterations in nutrition processes should be part of the comprehensive assessment of cancer patients.

Resumen Introducción Los trastornos y dificultades para la alimentación son problemas comunes en la edad pediátrica. Estas situaciones conllevan una serie de comportamientos inadecuados respecto de los procesos de nutrición que pueden afectar de manera adversa el desarrollo psicomotor, psicosocial y físico del niño. El objetivo de este trabajo fue describir la frecuencia de desórdenes y dificultades en la alimentación en niños con cáncer a través de un estudio prospectivo. Métodos Se incluyeron 125 niños de 1 a 19 años de edad del Servicio de Oncología del Instituto Nacional de Pediatría, Ciudad de México. El diagnóstico de desorden y dificultad en la alimentación se determinó en las primeras 48 horas del ingreso. Resultados Los niños mayores de 11 años presentan con mayor frecuencia resistencia a comer debido a dolor o malestar (miedo a comer) (11.4±4.7 años versus 7.4±4.9 años; p≤0.001). La alteración más frecuente asociada a malnutrición fue la disminución del apetito (razón de momios [RM]: 8.8; intervalo de confianza [IC] 95%: 2.9-26.9; p<0.001), seguido del miedo a comer (RM: 3.14; IC 95%: 1.24-7.9; p=0.015) y las causas con mayor riesgo de malnutrición fueron las orgánicas (RM: 3.1; IC 95%: 0.98-9.7; p=0.054). Conclusiones Se encontró que en más del 90% de esta población se presentó por lo menos un desorden alimentario o dificultad al alimentarse. El principal efecto es la ingesta nutricional inadecuada debida al apetito limitado y al miedo a alimentarse, lo que puede resultar en desnutrición. Por esta razón, la identificación de alteraciones en los procesos de nutrición deben ser parte de la valoración integral de los pacientes con cáncer.

Growth and digestive enzymes of silver catfish fed diets containing fruit residue / Crescimento e enzimas digestivas de jundiás alimentados com dietas contendo resíduos de frutas

In fish farming, the use of alternative ingredients has been studied, so that alternative sources can be used to minimize feed costs. This study evaluated the incorporation of grape, orange, guava, and fig residues in diets for silver catfish and its effects on growth, digestive enzymes and body composition. A total of 180 fish (initial mean weight = 22.93±0.75 g) were reared in a recirculation aquaculture system. There was no difference (P>0.05) in the parameters of growth, dry matter, mineral matter, plasma protein, cholesterol, triglycerides, lipase, and trypsin of fish. Glucose levels were higher in fish fed diets containing fig, orange, and grape residue (P<0.05). Lipase activity was higher in fish fed orange residue, compared to guava (P<0.05). Diets containing guava and fig provided more body protein in silver catfish. The fish fed with diet containing orange residue had a higher content of body lipids. It can be concluded that the tested fruit residues can be used in silver catfish feeding.(AU)

Na piscicultura, o uso de ingredientes alternativos vem sendo estudado, de modo que seja possível utilizar fontes alternativas para minimizar custos com a alimentação. Neste estudo, foi avaliada a incorporação de resíduos de uva, laranja, goiaba e figo em rações para jundiá e seus efeitos no crescimento, em enzimas digestivas e na composição corporal. Foram utilizados 180 peixes (peso médio inicial = 22,93±0,75 g), criados em sistema de recirculação. Não houve diferença (P>0,05) nos parâmetros de crescimento, matéria seca, matéria mineral, proteína plasmática, colesterol, triglicerídeos, lipase e tripsina dos peixes. Os níveis de glicose foram maiores nos peixes alimentados com dietas contendo figo, laranja e uva (P<0,05). A atividade de lipase foi maior nos peixes alimentados com resíduo de laranja, comparado com o de goiaba (P<0,05). As dietas contendo goiaba e figo proporcionaram mais proteína corporal nos jundiás. Os jundiás alimentados com dieta contendo resíduo de laranja apresentaram maior teor de lipídeos corporal. Conclui-se que os resíduos de frutas testados podem ser usados na alimentação do jundiá.(AU)

La nutrición enteral temprana debe iniciarse en todos los recién nacidos prematuros sin importar sus riesgos asociados / Early enteral nutrition should be initiated in all preterm infants regardless of their associated risks

Contexto: El inicio temprano de la nutrición enteral en los recién nacidos prematuros contribuye a menor duración de la alimentación parenteral, menos días de uso de catéter venoso central, menor número de casos de sepsis y una estancia hospitalaria menor. Propósito: Determinar las ventajas que tienen los prematuros que reciben nutrición enteral precoz sobre los prematuros que no reciben nutrición enteral precoz. Sujetos y métodos: Estudio multicéntrico, epidemiológico, observacional, transversal de dos cohortes. Población: prematuros hospitalizados en servicios de neonatología de la ciudad de Quito de mayo a octubre de 2018. Muestra: 204 casos. Resultados: se analizaron 204 casos, recién nacidos prematuros, la mitad de los cuales habían recibido nutrición enteral temprana; la mayoría de los recién nacidos pertenecieron al grupo de entre 32 y 36 semanas de edad gestacional con el 66.2% (n=135); pérdidas de peso superiores al 20% a los 7 días de vida predominó de manera significativa en el grupo de nutrición tardía (2.0 % vs. 12.7 %, p = 0.01); los pacientes que iniciaron nutrición tempranamente incrementaron de peso a los 14 días de seguimiento en el 77.5 % (n = 79/102) comparado con el grupo de nutrición tardía que incrementó de peso en el 48 % (n = 49/102), esto significó una diferencia absoluta del 29.4 % (IC 95 %: 15.8, 43 %; p < 0.001) entre grupos; se determinó una tendencia al uso más prolongado de catéter venoso central; en cuanto a los días de uso de nutrición parenteral las diferencias entre grupos fueron más pequeñas y no alcanzaron significancia estadística entre grupos (p = 0.15); Conclusión: El inicio de la nutrición enteral sea temprana o tardía no se relaciona significativamente con la mortalidad; se estableció una relación entre la nutrición enteral tardía y la frecuencia de casos de sepsis, enterocolitis necrotizante, hiperbilirrubinemia y tiempo de hospitalización más prolongado

Context: The early start of the enteral feeding in the premature newborns contribute to shorter duration of parenteral nutrition, less days of use of venous central catheter, fewer numbers of cases of sepsis, less frequent of hyperbilirubinemia and minor hospital stay. Aim: To determine the advantage that have the premature newborns who receive early enteral feeding over the premature newborns who do not receive early enteral feeding. Subjects and methods: This are a multicentric, epidemiological, observational, cross-sectional, of cohorts of patients comparing the early start of the enteral feeding in the premature newborns versus the late start of the enteral feeding. Population: premature newborns admitted in Neonatology services of Quito from May to October 2018. Sample: 204 cases. Results: 204 cases were analyzed, premature newborns, half of which received early enteral feeding, most newborns belonged to the group of 32-36 weeks of gestational age with 66.2% (n=135); the weight loss of 20% or more at 7 days of life were predominated in the late enteral nutrition (2.0 % vs. 12.7 %, p = 0.01); the patients who started the enteral nutrition early gained weight to the 14 days of live in 77.5 % (n = 79/102) compared with the group of late nutrition who gain weight in 48 % (n = 49/102), this means absolute difference of 29.4 % (IC 95 %: 15.8, 43 %; p < 0.001) between groups; a trend was determined to the longer use of central venous catheter in the late enteral feeding ; the differences between groups of the days of use of parenteral nutrition were not significant (p = 0.15). Conclusion: There is no significant relationship between the beginning of nutrition and the mortality; a direct relationship is established between the late enteral nutrition and the frequency of sepsis, necrotizing enterocolitis, hyperbilirubinemia and the longer hospitalization time

Evaluación antropométrica según el Indice de Masa Corporal en universitarios de Quito / Anthropometric assessment according to body mass index in a university of Quito / Avaliação antropométrica de acordo com o Índice de Massa Corporal em estudantes universitários de Quito

RESUMEN Objetivo Evaluar el estado nutricional según el índice de masa corporal de los estudiantes universitarios de pregrado de la Universidad Central del Ecuador (UCE) y de la Universidad Tecnológica Equinoccial (UTE) de la ciudad de Quito, estableciendo sujetos de estudio con un perfil entre los 19 a 24 años de edad a través del uso de indicadores antropométricos. Metodología Se estableció una muestra conformada por 235 estudiantes que regularmente utilizan los comedores universitarios; de este estudio el 53% eran mujeres y el 47% hombres. Para esto se tomó como dimensión un estudio comprendido entre el periodo julio de 2013 a marzo de 2014. Resultados Entre los principales resultados se determinó que existió una prevalencia de malnutrición de 28,1%, en donde se evidenció una mayor presencia de exceso de peso (22,1%) que de déficit (6,0%); estos datos fueron más críticos para los hombres, con un 34,2% frente al 22,6% de las mujeres. Conclusión Los resultados de sobrepeso y obesidad encontrados en los estudiantes universitarios ecuatorianos fueron de 18,3% y 3,8%, respectivamente, inferiores que los reportados para el país, en la Encuesta Nacional de Salud y Nutrición en 2013.(AU)

ABSTRACT Objective To evaluate the nutritional status of undergraduate university students aged between 19 and 24 years, from the Universidad Central de Ecuador (UCE) and the Universidad Tecnológica de Ecuador (UTE) of Quito, according to the body mass index (BMI) and using anthropometric indicators. Materials and Methods A sample was established consisting of 235 students who regularly use university canteens (53% women; 47% men). The study was carried out between July 2013 and March 2014. Results A prevalence of malnutrition was found in 28.1% of the sample, evidencing a higher percentage of overweight (22.1%) than of low weight (6.0%). These data were more critical in men (34.2%) than in women (22.6%). Conclusion Overweight and obesity in Ecuadorian university students were 18.3% and 3.8%, respectively, which is lower than the figures reported for the country in the National Health and Nutrition Survey.(AU)

RESUMO Objetivo Avaliar o estado nutricional de estudantes universitários de graduação com idade entre 19 e 24 anos, da Universidad Central de Ecuador (UCE) e da Universidad Tecnológica de Ecuador (UTE) de Quito, segundo o índice de massa corporal (IMC) e por meio de indicadores antropométricos. Materiais e métodos Estabeleceu-se uma amostra de 235 alunos que frequentam regularmente cantinas universitárias (53% mulheres; 47% homens). O estudo foi realizado entre julho de 2013 e março de 2014. Resultados Foi encontrada prevalência de desnutrição em 28,1% da amostra, evidenciando maior percentual de sobrepeso (22,1%) do que de baixo peso (6,0%). Esses dados foram mais críticos nos homens (34,2%) do que nas mulheres (22,6%). Conclusão O sobrepeso e a obesidade em estudantes universitários equatorianos eram de 18,3% e 3,8%, respectivamente, o que é inferior aos dados relatados para o país na Pesquisa Nacional de Saúde e Nutrição.(AU)

Biomarcadores del metabolismo y nutrición de hierro / Biomarkers of metabolism and iron nutrition

La anemia por deficiencia de hierro continúa siendo la deficiencia nutricional más abundante en el mundo, y son los lactantes, preescolares, mujeres en edad fértil y embarazadas los grupos de mayor susceptibilidad. Debido a esto es que se hace necesario el conocer los mecanismos de regulación de captación, transporte y absorción del metal a nivel celular, principalmente a nivel del enterocito y, una vez que el hierro entra a la circulación, conocer cuáles son los biomarcadores que permiten realizar un seguimiento del estatus del hierro corporal. En esta revisión mostramos, en primer lugar, cómo se regula la entrada de hierro a nivel de la célula del epitelio intestinal, mostrando las principales proteínas involucradas (transportadores de entrada y salida de hierro, oxido-reductasas, proteína de almacenamiento) y, para finalizar, hacemos un recuento de los principales biomarcadores del metabolismo de hierro una vez que este ha entrado y circula por el organismo.

Iron deficiency anemia is the most common nutritional deficiency worldwide, and the most susceptible groups are infants, preschoolers, women of childbearing age, and pregnant women. It is therefore essential to understand the mechanisms of regulation of iron uptake, transport, and absorption at the cellular level, particularly in enterocytes, and to identify blood biomarkers that allow the evaluation of iron status. This review describes how iron absorption is regulated by intestinal epithelial cells, the main proteins involved (iron transporters, oxidoreductases, storage proteins), and the main blood biomarkers of iron metabolism.

Fenótipo da cintura hipertrigliceridêmica e fatores nutricionais: um estudo com participantes do ELSA-Brasil / Hypertriglyceridemic waist phenotype and nutritional factors: a study with participants of ELSA-Brasil

RESUMO: Objetivo: Investigar a associação entre consumo de gorduras e fibras e o fenótipo da cintura hipertrigliceridêmica (FCH). Métodos: Pesquisa de corte transversal conduzida a partir da linha de base do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Foi realizada avaliação antropométrica e calculado o Índice de Massa Corporal (IMC). Os participantes foram classificados segundo presença do FCH quando circunferência da cintura ≥ 102 e ≥ 88 cm, respectivamente, em homens e mulheres, e triglicerídeos ≥ 150 mg/dL. O consumo de gorduras e fibras foi avaliado a partir de um Questionário de Frequência Alimentar validado e as variáveis socioeconômicas, demográficas e características comportamentais foram coletadas por meio de questionário. Foram realizados testes do χ2, Mann-Whitney e regressão de Poisson com significância de 5%. Resultados: Homens apresentaram menor prevalência do FCH (RP = 0,959; IC95% 0,948 - 0,969). Maiores prevalências de FCH foram observadas em indivíduos com atividade física fraca (RP = 1,039; IC95% 1,021-1,057), histórico de tabagismo (RP = 1,044; IC95% 1,031-1,057), menor renda per capita (IRR = 1,035; IC95% 1,022-1,049) e obesidade (RP = 1,32; IC95% 1,305-1,341). Consumo de gorduras e fibras não foi associado ao FCH. Conclusão: Maior prevalência do FCH foi encontrada em obesos, porém não foi observada associação entre o consumo de gorduras e fibras e o fenótipo.

ABSTRACT: Objective: To investigate the association between fat and fiber intakes and the hypertriglyceridemic waist phenotype (HWP). Methods: Cross-sectional survey conducted from the baseline of Brazilian Longitudinal Study of Health Adult (ELSA-Brasil). Anthropometric measurements were conducted and the body mass index was calculated (BMI). Participants were classified according to the presence of HWP when waist circumference ≥ 102 and ≥ 88 cm, respectively, in men and women, and triglycerides ≥ 150 mg/dL. Fat and fiber intakes were assessed using a validated food frequency questionnaire, and socioeconomic, demographic and behavioral variables were collected through a questionnaire. The χ² test, Mann-Whitney and Poisson regression were performed with significance level of 5%. Results: There was no association between fiber and fat intakes with HWP. A lower prevalence of HWP among men was observed (IRR = 0.959; 95%CI 0.948 - 0.969). A higher prevalence of HWP was observed in participants with low physical activity (OR = 1.039, 95%CI 1.021 - 1.057), smoking history (OR = 1.044, 95%CI 1.031 - 1.057), lower per capita income (IRR = 1.035; 95%CI 1.022 - 1.049) and obesity (OR = 1.32, 95%CI 1.305 - 1.341). Fat and fiber intakes were not associated with HWP. Conclusion: A higher prevalence of HWP was found in obese, but no association was found between intake of fat and fiber and phenotype.

Níveis de suplementação de vitamina K para codornas de corte em crescimento de 15 a 35 dias de idade / Vitamin K supplementation for meat quail in growth of 15 to 35 days old

O presente experimento foi realizado com o objetivo de determinar os níveis de suplementação de vitamina K para codornas de corte. O delineamento experimental foi inteiramente ao acaso, com oito tratamentos, cinco repetições e 38 codornas por unidade experimental. Os níveis de suplementação de vitamina K foram: 0; 0,7; 1,0; 1,3; 1,6; 1,9; 2,2; 2,5mg/kg de ração. Não houve influência dos níveis de suplementação de vitamina K sobre o consumo de ração, peso corporal, ganho de peso, biomassa corporal acumulada e conversão alimentar, como também não foram alterados o peso, a densidade óssea, a resistência óssea e a concentração de cinzas no fêmur e na tíbia, o comprimento e o índice de Seedor do fêmur e o diâmetro da tíbia. O diâmetro e a concentração de cálcio no fêmur bem como o comprimento e a concentração de cálcio na tíbia responderam de forma quadrática (P<0,05), sendo os melhores níveis encontrados de 1,33; 1,42; 1,59 e 1,42mg de vitamina K, respectivamente. O tempo de protrombina, a concentração de cálcio no soro e a fosfatase alcalina também não foram afetados significativamente. Conclui-se que os níveis de suplementação não influenciaram o desempenho, portanto rações à base de milho e farelo de soja são suficientes para atender às necessidades de vitamina K das codornas nessa fase.(AU)

An experiment was carried out in order to determine the levels of vitamin K for meat quails. The experimental design was completely randomized with 8 treatments, 5 repetitions and 38 quails per experimental unit. The levels of vitamin K supplementation were 0; 0.7; 1.0; 1.3; 1.6; 1.9; 2.2; 2.5 mg/kg diets. There was no influence in the levels of vitamin K supplementation on feed intake, body weight, weight gain, biomass accumulated body and feed conversion. It also didn't affect the weight, bone density, bone strength and concentration of ash in the femur and tibial, length, index of Seedor femur and tibial diameter. Femur diameter and femur calcium concentration and the tibial length and tibial calcium concentration showed a quadratic response, with the highest levels found 1.33; 1.42; 1.59 and 1.42 mg of vitamin respectively. Prothrombin time, concentration of serum calcium and alkaline phosphatase levels also were not significantly affected. In conclusion, levels of supplementation did not influence the performance of meat quails, so diets based on corn and soybean meal are sufficient to meet the needs of the meat quails at this stage.(AU)

Factores de riesgo metabólico y no metabólico en personas adultas de un centro de salud del Estado de México / Metabolic and non-metabolic risk factors in adults from a health center in the Estado de México

ResumenIntroducción: en las últimas décadas la diabetes mellitus 2 (DM2) ha tenido un incremento notable en México. En el año 2000 la Encuesta Nacional de Salud reportó 2.1 millones de personas afectadas; en 2006, 3.7 millones; y en 2012, 6.4 millones. Aunada a la enfermedad cardiovascular la DM2 representa la primera causa de mortalidad con tendencia al incremento progresivo en los últimos años. Objetivo: identificar y describir los factores de riesgo metabólico y no metabólico en personas adultas matriculadas en un centro de salud del Estado de México.Metodología: en una muestra no probabilística de 586 personas de ambos sexos, se formaron tres grupos con glucosa normal (GN), glucosa alterada en ayuno (GAA) y DM2. Se midieron variables no metabólicas (peso, estatura y circunferencia de cintura) y metabólicas (triglicéridos, c-HDL, c-LDL, tensión arterial sistólica y diastólica).Resultados: las medias del nivel de colesterol total en los tres grupos fueron más elevadas en el grupo con GN: 203.6 ± 36.7 mg/dl_ frente a 199.4 ± 39.7 mg/dL del grupo de GAA y 200.6 ± 44.7 mg/dL del de DM2. Los niveles séricos de c-LDL en los grupos GN y GAA fueron similares con 120.7 ± 32.3 frente a 120.5 ± 33.7, respectivamente. En el grupo de DM2 disminuyó la concentración sérica de c-LDL, con un resultado de 114.6 ± 36.5 mg/dL.Conclusiones: se encontró una alta frecuencia de alteraciones en el perfil lipídico y la presión arterial diastólica, así como obesidad abdominal en las personas con DM2 y en la población sin diabetes.

AbstractIntroduction: In the last decades, type 2 diabetes mellitus (T2DM) has increased considerably in Mexico. In 2000 the National Health Survey reported 2.1 millions of people affected; in 2006, 3.7 millions; and in 2012, 6.4 millions. Acting together, T2DM and cardiovascular disease are the leading cause of mortality with a trend that is increasing progressively in recent years.Objective: To identify and describe metabolic and non-metabolic risk factors in adults enrolled in a health center in the Estado de México.Methods: A non-random sampling of 586 male and female patients was divided into three groups: normal glucose (NG), impaired fasting glucose (IFG) and T2DM. Metabolic (triglycerides, HDL-cholesterol, LDL-cholesterol, as well as systolic and diastolic blood pressure) and non-metabolic (weight, height and waist circumference) variables were measured.Results: Mean levels of total cholesterol in the three groups were higher in the GN group with 203.6 ± 36.7 mg/dL vs. 199.4 ± 39.7mg/dL vs. 200.6 ± 44.7mg/dL, respectively. Serum levels of LDL-cholesterol in the GN and GAA groups were similar with 120.7 ± 32.3 vs. 120.5 ± 33.7, respectively; in the T2DM group, the serum level of LDL-C decreased (114.6 ± 36.5 mg/dL).Conclusions: Our findings show that patients with T2DM along with patients without diabetes show high frequency of alterations in lipid profiles and diastolic blood pressure, as well as abdominal obesity.

Technological information regarding prebiotics and probiotics nutrition versus the patent registers: what is new? / Informação tecnológica relacionada aos pré e probióticos com base no registro das patentes: o que há de novo?

ABSTRACT Introduction: Food is a key factor both in prevention and in promoting human health. Among the functional food are highlighted probiotics and prebiotics. Patent databases are the main source of technological information about innovation worldwide, providing extensive library for research sector. Objective: Perform mapping in the main patent databases about pre and probiotics, seeking relevant information regarding the use of biotechnology, nanotechnology and genetic engineering in the production of these foods. Method: Electronic consultation was conducted (online) in the main public databases of patents in Brazil (INPI), United States (USPTO) and the European Patent Bank (EPO). The research involved the period from January 2014 to July 2015, being used in the title fields and summary of patents, the following descriptors in INPI "prebiotic", "prebiotic" "probiotics", "probiotic" and the USPTO and EPO: "prebiotic", "prebiotics", "probiotic", "probiotics". Results: This search haven't found any deposit at the brazilian patents website (INPI) in this period; US Patent &Trademark Office had registered 60 titles in patents and the European Patent Office (EPO) showed 10 documents on the issue. Conclusion: Information technology offered by genetic engineering, biotechnology and nanotechnology deposited in the form of titles and abstracts of patents in relation to early nutritional intervention as functional foods, has increasingly required to decrease the risks and control the progression of health problems. But, the existing summaries, although attractive and promising in this sense, are still incipient to recommend them safely as a therapeutic tool. Therefore, they should be seen more as diet elements and healthy lifestyles.

RESUMO Introdução: A alimentação é fator primordial tanto na prevenção quanto na promoção para a saúde humana. Dentre os alimentos funcionais destacam-se os probióticos e prebióticos. Os bancos de dados de patentes representam a maior fonte de informação tecnológica acerca de inovação em nível mundial, provendo vasta biblioteca para o setor de pesquisa. Objetivo: Realizar mapeamento nas principais bases de dados de patentes relacionada aos pré e probióticos buscando informações relevantes com relação ao uso da biotecnologia, nanotecnologia e engenharia genética na produção desses alimentos. Método: Foi realizada consulta eletrônica (online) nas principais bases de dados públicas de patentes do Brasil (INPI), Estados Unidos da América (USPTO) e o Banco de Patentes Europeu (EPO). A pesquisa envolveu o período de janeiro de 2014 a julho 2015, sendo utilizado nos campos de título e resumo das patentes, os seguintes descritores no INPI: "prebiótico", "prebióticos" "probiótico", "probióticos" e no USPTO e EPO: "prebiotic", "prebiotics", "probiotic", "probiotics" Resultados: Não foram observados, no INPI, depósitos de residentes (empresas ou universidades). Já no USPTO foram detectados 60 depósitos e no EPO 10 títulos de interesse à pesquisa. Conclusão: A tecnologia da informação ofertada pela engenharia genética, biotecnologia e nanotecnologia depositada na forma de títulos e resumos das patentes em relação à intervenção nutricional precoce como alimentos funcionais, tem cada vez mais pretendido diminuir os riscos e controlar a progressão de agravos à saúde. Mas, os resumos existentes, embora atraentes e promissores neste sentido, ainda são incipientes para recomendá-los de forma segura como ferramenta terapêutica. Portanto, devem ser encarados mais como integrantes de dieta e estilos de vida saudáveis.