Historicizando a trajetória de um pioneiro: Reinier Johannes Antonius Rozestraten (1924-2008) / Historicizing a pioneer: Reinier Johannes Antonius Rozestraten (1924-2008)

As biografias têm ganhado espaço na História das Ciências, no geral e, em específico, na História da Psicologia. Elas têm permitido compreender a atuação de personagens relevantes na história da Psicologia, em diversos locais e, entre eles, no Brasil. Esteartigo se constitui como uma biografia de Reinier Johannes Antonius Rozestraten (1924-2008). A partir de fontes textuais (e.g., memoriais, relatórios, etc.) e orais (entrevista com ex-colegas e ex-alunos), apresentamos cidades pelas quais o biografado passou e parte de suas atividades vinculadas ao campo científico-profissional da Psicologia. As fontes foram analisadas a partir de seu conteúdo. Vemos um ator interessado em uma Psicologia científica, capaz de se envolver em questões aplicadas, do que a de uma personagem vinculada a uma teoria, em especial. Ademais, observamos uma atuação que concorreu à criação e desenvolvimento de Sociedades científico-profissionais. Assim, sua trajetória nos permite compreender os caminhos da Psicologia, no geral, e da Psicologia do Trânsito, em específico, no Brasil.

Biographies have calling attention in the History of Sciences, in general and, in particular, in the History of Psychology. They have allowed us to understand the role of relevant characters in the history Psychology, in different places and, among them, in Brazil. This article is a biography of Reinier Johannes Antonius Rozestraten (1924-2008). From textual (e.g., memorial, research reports, etc.) and oral sources (interview with colleagues and former students), we present cities through which he passed and part of his activities linked to the scientific-professional field of Psychology. Primary sources were analyzed from its contents. We note Rozestraten more interested in scientific psychology, capable of getting involved in applied issues, than that of acharacter linked to a theory, in particular. In addition, we observed an activity that contributed to the creation and development of various scientific-professional societies. Thus, its trajectory allows us to understand the paths of Psychology, in general, and of Traffic Psychology, in specific, in Brazil.

Impacto social de la despenalización de la muerte médicamente asistida / The social impact of physician-assisted death legalization

The debate on legalization of physician-assisted death (PAD) has focused on its purely individual aspects, leaving aside equally relevant social dimensions such as a progressive expansion of PAD's causes, strains and changes in the doctor-patient relationship, and unreported PADs. The aim of this work was to explore these aspects through an analysis of the experience of Belgium and the Netherlands, countries where PAD is legal since 2002. The results, obtained through a systematic review of the literature, indicate that in both countries, the acceptance of the concept of "psychological suffering" allowed PAD to be performed in psychiatric patients, in persons with dementia and in older people with geriatric conditions. The acceptance to perform a PAD has a significant emotional burden for the physician who must assume the role of executor of the patient's will, which is aggravated by pressures from patients and their relatives. Moreover, more than 30% of PADs are not reported. All this information was obtained from physicians not willing to incriminate themselves, after the commission of the PADs, therefore hampering the monitoring of law abiding. These results reveal the existence of a social impact of PAD decriminalization that deserves greater consideration and further studies.

Why Using Religious Arguments in the Euthanasia Discussion is Problematic / Por qué hacer uso de argumentos religiosos en el debate sobre la eutanasia es un tema problemático / Por que usar argumentos religiosos no debate sobre a eutanásia é um tema problemático

Abstract: In discussions about assisted dying (euthanasia, assisted suicide), those who argue 'against' legalisation often reason from a religious angle, whereas those 'in favour' adopt a secular stance. The Dutch experience is more nuanced: here, euthanasia advocacy largely originated from protestant religious believers. In this contribution, I criticise the use of religious arguments favouring any specific position. Religion may provide a heuristic context to explore norms relevant in the discussion, and religion may help us formulate our personal stance. But when it comes to societal debates (often focusing on whether or not to legalise euthanasia), we should concentrate on legal, societal, empirical, and ethical arguments that are understandable to all.

Resumen: en discusiones sobre la muerte asistida (eutanasia, suicidio asistido), aquellos que argumentan estar "en contra" de la legalización a menudo razonan desde un ángulo religioso, mientras que los que están "a favor" adoptan una postura secular. La experiencia holandesa es más matizada: aquí, la defensa de la eutanasia se originó en gran medida por creyentes religiosos protestantes. En esta contribución, critico el uso de argumentos religiosos que favorezcan cualquier posición específica. La religión puede proveer un contexto heurístico para explorar normas relevantes en la discusión, y la religión puede ayudarnos a formular nuestra postura personal. Pero cuando se trata de debates sociales (a menudo enfocados en la legalización o no de la eutanasia), debemos concentrarnos en argumentos jurídicos, sociales, empíricos y éticos que sean comprensibles para todos.

Resumo: Em discussões sobre a morte assistida (eutanásia, suicidio assistido), os que argumentam estar "contra" a legalização com frequência pensam a partir de um ângulo religioso, enquanto os que estão "a favor" adotam um posicionamento secular. A experiência holandesa é mais fusionada: aqui, a defesa da eutanásia foi originada em grande medida por crentes religiosos protestantes. Nesta contribuição, critico o uso de argumentos religiosos que favoreçam qualquer posicionamento específico. A religião pode promover um contexto heurístico para explorar normas relevantes na discussão, e a religiao pode ajudarnos a formular nosso posicionamento pessoal. Contudo, quando é tratado de debates sociais (às vezes focados na legalização ou não da eutanásia), devemos concentrar-nos em argumentos jurídicos, sociais, empíricos e éticos que sejam compreensíveis para todos.

Contribution of amenable mortality to life expectancy differences between the Dutch Caribbean islands of Aruba and Curaçao and the Netherlands / Contribución de la mortalidad por causas evitables mediante la atención de salud a la diferencia de la esperanza de vida entre las islas del Caribe holandés de Aruba y Curaçao y los Países Bajos / Contribuição da mortalidade evitável para as diferenças na expectativa de vida entre as ilhas de Aruba e Curaçao, no Caribe holandês, e os Países Baixos

ABSTRACT Objective. To identify specific health care areas whose optimization could improve population health in the Dutch Caribbean islands of Aruba and Curaçao. Methods. Comparative observational study using mortality and population data of the Dutch Caribbean islands and the Netherlands. Mortality trends were calculated, then analyzed with Joinpoint software, for the period 1988-2014. Life expectancies were computed using abridged life tables for the most recent available data of all territories (2005-2007). Life expectancy differences between the Dutch Caribbean and the Netherlands were decomposed into cause-specific contributions using Arriaga's method. Results. During the period 1988-2014, levels of amenable mortality have been consistently higher in Aruba and Curaçao than in the Netherlands. For Aruba, the gap in amenable mortality with the Netherlands did not significantly change during the study period, while it widened for Curaçao. If mortality from amenable causes were reduced to similar levels as in the Netherlands, men and women in Aruba would have added, respectively, 1.19 years and 0.72 years to their life expectancies during the period 2005-2007. In Curaçao, this would be 2.06 years and 2.33 years. The largest cause-specific contributions were found for circulatory diseases, breast cancer, perinatal causes, and nephritis/nephrosis (these last two causes solely in Curaçao). Conclusions. Improvements in health care services related to circulatory diseases, breast cancer, perinatal deaths, and nephritis/nephrosis in the Dutch Caribbean could substantially contribute to reducing the gap in life expectancy with the Netherlands. Based on our study, we recommend more in-depth studies to identify the specific interventions and resources needed to optimize the underlying health care areas.(AU)

RESUMEN Objetivo. Determinar las áreas específicas de atención de salud cuya optimización podría mejorar la salud de la población en las islas del Caribe holandés de Aruba y Curaçao. Métodos. Estudio de observación comparativo en el que se utilizaron datos demográficos y de mortalidad de las islas del Caribe holandés y de los Países Bajos. Se calcularon las tendencias de mortalidad y luego se analizaron con programas de computación Jointpoint de regresión lineal segmentada, para el período 1988-2014. La esperanza de vida se calculó utilizando tablas de mortalidad abreviadas con los datos más recientes disponibles de todos los territorios (2005-2007). Las diferencias de esperanza de vida entre el Caribe holandés y los Países Bajos se desglosaron, usando el método de Arriaga, en contribuciones por causas específicas. Resultados. En el período 1988-2014, los niveles de mortalidad por causas evitables mediante la atención de salud han sido sistemáticamente mayores en Aruba y Curaçao que en los Países Bajos. En el caso de Aruba, la brecha en la mortalidad por causas evitables mediante la atención de salud con respecto a los Países Bajos no varió significativamente durante el período de estudio; en el caso de Curaçao, la brecha fue mayor. Si la mortalidad por causas evitables mediante la atención de salud se redujese a un nivel similar al de los Países Bajos, los hombres y las mujeres en Aruba habrían sumado, respectivamente, 1,19 años y 0,72 años a su esperanza de vida en el período 2005-2007. En Curaçao, el aumento hubiese sido de 2,06 años y de 2,33 años. Según el estudio, las causas específicas que más contribuyen a esta diferencia son las enfermedades circulatorias, el cáncer de mama, las complicaciones perinatales, y la nefritis/nefrosis (estas últimas dos causas solamente en Curaçao). Conclusiones. Una mejora en los servicios de salud en relación con las enfermedades circulatorias, el cáncer de mama, las complicaciones perinatales, y la nefritis/nefrosis en el Caribe holandés podría contribuir sustancialmente a la reducción de la brecha en la esperanza de vida con respecto a los Países Bajos. Por tanto, con base en nuestro estudio, recomendamos que se realicen más estudios exhaustivos a fin de determinar las intervenciones específicas y los recursos que se necesitan para optimizar las áreas de atención de salud involucradas.(AU)

RESUMO Objetivo. Identificar áreas específicas da atenção à saúde cuja otimização poderia melhorar a saúde da população nas ilhas de Aruba e Curaçao, no Caribe holandês. Métodos. Estudo observacional comparativo baseado em dados de mortalidade e populacionais das ilhas do Caribe holandês e dos Países Baixos. As tendências de mortalidade foram calculadas e então analisadas com o software Joinpoint, no período de 1988 a 2014. As expectativas de vida foram computadas usando tábuas de mortalidade resumidas com os dados disponíveis mais recentes de todos os territórios (2005-2007). As diferenças na expectativa de vida entre o Caribe holandês e os Países Baixos foram desagregadas segundo as contribuições específicas por causa usando o método de Arriaga. Resultados. No período de 1988 a 2014, os níveis de mortalidade evitável foram consistentemente mais elevados em Aruba e Curaçao do que nos Países Baixos. Em Aruba, a diferença na mortalidade evitável em comparação com os Países Baixos não mudou significativamente durante o período do estudo, enquanto que em Curaçao a diferença aumentou. Se a mortalidade por causas evitáveis fosse reduzida a níveis semelhantes aos dos Países Baixos, os homens e mulheres de Aruba teriam aumentos respectivos de 1,19 e 0,72 anos nas suas expectativas de vida durante o período 2005-2007. Em Curaçao, o aumento seria de 2,06 e 2,33 anos. As maiores contribuições de causas específicas foram as de doenças circulatórias, câncer de mama, causas perinatais e nefrite/nefrose (estas duas últimas causas somente em Curaçao). Conclusões. Melhorias nos serviços de saúde relacionados com doenças circulatórias, câncer de mama, mortes perinatais e nefrite/nefrose no Caribe holandês poderiam contribuir substancialmente para reduzir as disparidades na expectativa de vida em comparação com os Países Baixos. Com base neste trabalho, recomendamos estudos mais aprofundados para identificar as intervenções e recursos específicos necessários para otimizar estas áreas da atenção à saúde.(AU)

Dutch translation and adaptation of the Barkley Deficits in Executive Functioning Scale (BDEFS)

Abstract Background Based on his model of self-regulation and executive functions, Barkley developed a self- and other-report questionnaire (the Barkley Deficits in Executive Functioning Scale - BDEFS). The BDEFS measures deficits in executive functions as expressed in daily life activities like self-management of time, self-organization, self-restraint, self-motivation, and self-regulation of emotion. Objectives This study created and analyzed a Dutch translation and adaptation in conformance with official guidelines. Methods The Dutch and English BDEFS were completed by 25 bilingual Dutch adults to evaluate semantic correspondence. Consequently, 60 Dutch participants completed the Dutch BDEFS, Barratt Impulsiveness Scale-Eleventh edition (BIS-11) and the Dysexecutive Questionnaire (DEX) to evaluate concurrent validity and internal consistency. Results The versions demonstrated sufficient semantic equivalence and Spearman's rho of total scores was high; items mostly showed moderate-to-high correlations. Regression analysis showed no proportional bias. Internal consistency was also high. Correlations between BDEFS, BIS-11 and DEX supported concurrent validity. Discussion We conclude that a successful BDEFS translation and adaptation was created with satisfactory reliability and validity. Further research should assess the utility of the BDEFS in Dutch clinical practice.

Historia sucinta de Candida albicans, blanca pero no tanto / Brief history of Candida, white but not so much

From the begin of clinical microbiology in the second half of the nineteenth century, the fungi were neglected as contaminants without relevance for health, belonging the major advances of their study to the fields of milk derivatives and beer industries. However, the seek for the etiological agent of thrush, a very common oral pathology affecting the newborn, put the yeasts on the table near 1840 with three capital papers - Berg, Gruby and Bennett - speaking about spores from vegetable as parasites of animal and human beings. The door was open, and very soon, in 1853, came the decisive description by Robin of the Oidium albicans as the causative agent of this painful disease. Seventy years after, in 1923, Christine Marie Berkhout, rejecting this name, defined the genus as Candida, leaving the specie with the iterative Latin name of Candida albicans, that means "White-white". Or, perhaps, with a fine sense of humor, she has made an oxymoron, because "candida" means a brilliant white and "albicans" a matt one, both opposite adjectives. Or, may be, Christine is still saying us: "White…but not so white".

Laparoscopic Radical Cystectomy in the Elderly - Results of a Single Center LRC only Series

ABSTRACT Objective: To compare outcome of laparoscopic radical cystectomy (LRC) with ileal conduit in 22 elderly ( (≥75 years) versus 51 younger (<75 years) patients. patients. Materials and Methods: Analysis of prospectively gathered data of a single institution LRC only series was performed. Selection bias for LRC versus non-surgical treatments was assessed with data retrieved from the Netherlands Cancer Registry. Results: Median age difference between LRC groups was 9.0 years. (77.0 versus 68.0 years). Both groups had similar surgical indications, body mass index and gender distribution. Charlson Comorbidity Index score was 3 versus 4 in ≥50% of younger and elderly patients. Median operative time (340 versus 341 min) and estimated blood loss (<500 versus >500mL) did not differ between groups. Median total hospital stay was 12.0 versus 14.0 days for younger and elderly patients. Grade I-II 90-d complication rate was higher for elderly patients (68 versus 43%, p=0.05). Grade III-V 90-d complication rate was equal for both groups (23 versus 29%, p=0.557). 90-d mortality rate was higher for elderly patients (14 versus 4%, p=0.157). Median follow-up was 40.0 months for younger and 57.0 months for elderly patients. Estimated overall and cancer-specific survival at 5years. was 46% versus 35% and 64% versus 64% for younger and elderly patients respectively. Conclusions: Our results suggest that LRC is feasible in elderly patients, where a non-surgical treatment is usually favoured.

Nivel y cambio de la mortalidad vial en Argentina, Chile, Colombia y México, 2000-2011 / Level of and change in road traffic mortality in Argentina, Chile, Colombia and Mexico, 2000-2011

El objetivo de este trabajo es estimar el efecto de las muertes por atropellos y colisiones de tránsito en la esperanza de vida en Argentina, Chile, Colombia y México, entre 2000 y 2011. Se calcularon los años de esperanza de vida perdidos (AEVP) para los trienios 2000-2002 y 2009-2011. Los resultados indican que los decesos ocurridos por el tránsito representaron entre el 1% y el 4% del total para cada país. En el primer trienio, el mayor nivel de mortalidad ocurrió en Colombia (AEVP=0,96), mientras que el más bajo se registró en Argentina (AEVP=0,59). A excepción de este último país, hacia el segundo trienio, se redujo el impacto de estos fallecimientos sobre la esperanza de vida. El principal cambio tuvo lugar en Colombia que pasó a 0,72 AEVP. Se concluye que las muertes asociadas con el tránsito impactan de manera negativa en los sistemas de salud, las víctimas, el sector productivo y la sociedad en general. Desde esta perspectiva, la situación vial representa un problema de salud pública que requiere la intervención multisectorial en el diseño de políticas de alcance nacional y regional.

The aim of this study was to estimate the effect of run-over fatalities and traffic collisions in life expectancy in Argentina, Chile, Colombia and Mexico, between 2000 and 2011. Years of life expectancy lost (YLEL) were calculated for the periods 2000-2002 and 2009-2011. The results show that road traffic deaths made up between 1% and 4% of all deaths in each country. In the first period, the highest level of mortality occurred in Colombia (YLEL=0.96) and the lowest in Argentina (YLEL=0.59). In all the countries studied except Argentina, the impact of these deaths on life expectancy was reduced in the second period. The main change took place in Colombia, reaching 0.72 YLEL in the second period. It is concluded that traffic-related deaths have a negative impact on health systems, victims, the productive sector, and society in general. From this point of view, the issue of road transit must be considered a matter of public health, requiring multi-sector intervention in the design of national and regional policies.

“ Doentes e incapazes para marchar”: vida e morte no exército da Companhia Neerlandesa das Índias Ocidentais no Nordeste do Brasil, 1630-1654 / “ Sick and unable to march: ” life and death in the army of the Dutch West India Company in the Northeast of Brazil, 1630-1654

Dos diversos males que infligiram o exército da Companhia das Índias Ocidentais em seus anos de atividade no Brasil, poucos podem ser comparados às doenças. São escassos, todavia, os dados quantitativos apresentados na historiografia para mostrar seu impacto nas tropas. Além dos índices de baixas por doença que ceifavam muitos militares, sabe-se pouco sobre os tratamentos médicos oferecidos, as principais doenças que atingiam a tropa e suas causas. Este artigo traz elementos que ajudam a compreender aspectos pouco trabalhados em termos quantitativos e sistemáticos pela historiografia e demonstra como as doenças afligiam a companhia e embaraçavam suas ações no território.

Of the many evils that were inflicted upon the army of the West India Company in its years of activity in Brazil, few could be compared to diseases. However, there is little quantitative data in the field of historiography regarding the impact of disease on these troops. Apart from the limited amount of information about the diseases that affected many soldiers, little is known about the medical treatments that were available, the main diseases that affected the troops, and what were the causes. This article provides information to understand aspects that have been little studied in quantitative and systematic terms in the field of historiography, and demonstrates how the diseases afflicted the Company and affected its actions in the territory.

Internações sensíveis à atenção primária específicas de mulheres / Sensitive female-specific hospitalization in primary care

Objetivou-se analisar as internações por condições sensíveis à atenção primária (ICSAP) específicas em mulheres e os fatores que determinam ou influenciam a ocorrência dessas internações (fatores socioeconômicos, sociodemográficos e controle de saúde) por meio de um inquérito de morbidade hospitalar realizado com amostra de 429 mulheres internadas em hospitais conveniados ao Sistema Único de Saúde. O percentual de ICSAP foi 49,42% (n = 212), com destaque para as internações específicas do sexo feminino 19,35% (n = 83). Associaram ao risco de internar por CSAP: idade superior a 60 anos, baixa escolaridade, internação prévia, realização de controle regular de saúde, falta de vínculo com a Estratégia Saúde da Família (ESF) e ser gestante. As causas evidentes foram as condições relacionadas à gravidez, ao parto e ao puerpério e às inflamações nos órgãos pélvicos femininos. Os resultados sugerem falhas no atendimento ambulatorial que deveria ser oportuno e resolutivo no contexto da saúde da mulher.

The scope of this paper was to analyze female-specific sensitive hospitalization occurring in primary care conditions and factors that determine or affect the occurrence of such hospitalizations (social, economic and demographic factors; health control). Analysis was performed by surveys on hospital morbidity with a sample of 429 females attended in Unified Health System (SUS) contracted hospitals. The sensitive hospitalizations percentage in primary care reached 49.42% (n = 212), highlighting female-specific hospitalization at 19.35% (n = 83). Hospitalization risks comprised elderly people over sixty, low schooling, previous hospitalizations, normal health control, lack of association with the Family Health Strategy and pregnancy. Evident causes were related to conditions of pregnancy, childbirth, post-partum and inflammations of the female pelvic organs. Results suggested flaws in outpatient attendance that should be adequate and provide solutions in women’s health.

Craniovertebral junction malformation in Northeastern Brazil: the myth of the Dutch colonization / Malformação da junção craniovertebral no Nordeste do Brasil: o mito da colonização Holandesa

The high prevalence of craniovertebral junction malformation in Northeastern Brazil is historically associated with brachycephalic biotype (flat head), also common in this region. It has been postulated that this trait was introduced to this region by the Dutch during the colonial period in Brazil's history. Based on the confrontation of this paradigm against some historical facts, the authors concluded that the brachycephalic phenotype was inherited from prehistoric ancestors (Amerindians) who were already living in this region when white European men arrived.

A alta prevalência de malformação da junção craniovertebral no Nordeste do Brasil é historicamente associada ao biótipo braquicefálico (cabeça chata), também comum nessa região. Postula-se que essa característica tenha sido introduzida na região pelos holandeses durante o período colonial da história do Brasil. Com base na confrontação desse paradigma com alguns fatos históricos, os autores concluem que o fenótipo braquicefálico foi herdado de ancestrais pré-históricos (ameríndios) que já habitavam a região no momento da chegada do homem branco europeu.

Integrative Psychiatry. Conceptual foundation, implementation and effectiveness / Integrative Psychiatry. Conceptual foundation, implementation and effectiveness

Despite important progress in psychiatry not all patients respond well to available treatments. There are also concerns about increasing costs and the quality of the therapeutic relationship, which seems threatened by managed care, focus on protocols, and a tendency to reductionism, narrowing the view to diseases or symptoms and losing sight of the whole person in his or her context. 'Integrative medicine' is a new concept in health care defined as: 'the practice of medicine that reaffirms the importance of the relationship between practitioner and patient, focuses on the whole person, is informed by evidence, and makes use of all appropriate therapeutic approaches, healthcare professionals and disciplines to achieve optimal health and healing'. Integrative medicine may provide some solutions to the problems raised. However, there is a paucity of research on the application of integrative medicine in mental health care ('integrative psychiatry'). We explored the conceptual foundation of integrative psychiatry in the first part of this thesis. The second part is about its implementation in Dutch mental health care. Taking into account the Dutch law, jurisprudence, rules of professional bodies, and scientific research, we wrote a treatment protocol for the judicious application of complementary medicine in conventional mental health care. In the third part we assessed evidence for the effectiveness of integrative psychiatry and some selected complementary medicines and lifestyle changes. In the discussion we respond to criticism and offer suggestions for future research.

Doença celíaca é super-representada em pacientes com constipação / Celiac disease is overrepresented in patients with constipation

OBJETIVO: Tem sido sugerido que pacientes com constipação sejam triados para doença celíaca. Da mesma forma, recomenda-se a investigação desses pacientes para hipotiroidismo e hipercalcemia. Contudo, nenhuma evidência para essas recomendações está disponível até o momento. Assim, propusemos-nos determinar a prevalência de doença celíaca, hipotiroidismo e hipercalcemia em crianças com constipação. MÉTODOS: Estudo de coorte prospectivo com 370 pacientes consecutivos que preencheram os critérios de Roma III para constipação. Esses pacientes foram encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. RESULTADOS: A biópsia comprovou doença celíaca em sete desses pacientes. Isso é significativamente mais alto (p < 0,001) do que a prevalência de 1:198 de doença celíaca nos Países Baixos. Dois pacientes tinham tiroidite autoimune. Nenhum paciente tinha hipercalcemia. CONCLUSÕES: Conclui-se que a doença celíaca é significativamente super-representada em pacientes com constipação encaminhados por um clínico geral a um pediatra devido ao fracasso no tratamento com laxantes. Todos esses pacientes devem, portanto, ser triados para doença celíaca.

OBJECTIVE: It is suggested that patients with constipation should be screened for celiac disease. Similarly, it is recommended to investigate these patients for hypothyroidism and hypercalcemia. However, no evidence for these recommendations is available so far. We therefore set out to determine the prevalence of celiac disease, hypothyroidism, and hypercalcemia in children with constipation. METHODS: Prospective cohort study of 370 consecutive patients who met the Rome III criteria for constipation. These patients were referred by a general practitioner to a pediatrician because of failure of laxative treatment. RESULTS: Seven of these patients had biopsy-proven celiac disease. This is significantly higher (p < 0.001) than the 1:198 prevalence of celiac disease in the Netherlands. Two patients had auto-immune thyroiditis. No patient had hypercalcemia. CONCLUSIONS: We conclude that celiac disease is significantly overrepresented in patients with constipation who are referred by a general practitioner to a pediatrician because of failure of laxative treatment. All such patients should, therefore, be screened for celiac disease.

Medicina integradora: un puente entre la biomedicina y la medicina alternativa que se ajusta al espíritu de la época / Integrative Medicine: A Bridge between Biomedicine and Alternative Medicine Fitting the Spirit of the Age

Complementary and alternative medicine (CAM) are increasingly used by people in first world countries, almost always in combination with biomedicine. The combination of CAM and biomedicine is now commonly referred to as "integrative medicine" (IM). In Groningen, The Netherlands, we founded a center for integrative psychiatry, offering conventional and complementary mental health care. Like other centers for integrative (mental) health we have mostly received positive reactions although there have been negative and even hostile reactions as well, using phrases like "quackery" and "betrayal". We will try to illustrate that these polarising qualifications, in which "the good" is being positioned against "the bad" in an over-simplified manner, are unnecessary and not useful. Moreover, it is unlikely that this polarisation will stall the growth of IM. It seems that integration is not only a current tendency in medicine, but also a trend fitting the contemporary spirit of the age in which integration seems to be the most common focus. It can be observed in religion, philosophy, spirituality and psychotherapy as well. This article will discuss the difference between differentiation and integration and will show that the focus on differentiation or integration varies with time, mostly rising as a reaction to each other. The transition from one period to the next is often met with resistance and criticism. If the integrative movement is to survive, it cannot do without differentiation and must find a middle way in which appropriate attention is being paid to keeping the integrated parts sufficiently differentiated and allowing them to keep their own identity.