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2.
J Cutan Pathol ; 51(2): 108-113, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37828706

RESUMO

Perforating lichen nitidus is a rare subtype of lichen nitidus, with approximately 11 cases reported worldwide. Lesions typically present in young male patients at sites prone to mechanical irritation, including the hands, feet, forearms, elbows, and knees. Classic histopathologic features of perforating lichen nitidus show a lymphohistiocytic infiltrate within the papillary dermis between hyperplastic rete ridges with transepidermal elimination of dermal contents. Very few cases are reported in the literature of lichen nitidus and its association with atopic dermatitis. This is the first case describing perforating lichen nitidus in a patient with a history of atopic dermatitis being treated with dupilumab injections. Lesions of perforating lichen nitidus worsened with successful treatment of atopic dermatitis. These findings suggest a unique pathophysiology of perforating lichen nitidus lesions.


Assuntos
Dermatite Atópica , Líquen Nítido , Humanos , Masculino , Líquen Nítido/patologia , Dermatite Atópica/complicações , Dermatite Atópica/tratamento farmacológico , Dermatite Atópica/patologia , Pele/patologia
8.
An Bras Dermatol ; 97(1): 96-98, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34836740

RESUMO

Lichen nitidus is an uncommon lichenoid dermatosis that could be defined as multiple, separated, shiny, pinpoint, pale to skin-colored papules. Palmoplantar lichen nitidus is a quite rare variant of lichen nitidus. It is hard to make a diagnosis of palmar lichen nitidus when there are no lesions elsewhere on the body. There are some dermoscopic features defined for both palmoplantar and non-palmoplantar lichen nitidus that might be useful to facilitate the diagnosis before histopathological examination. Herein, we report a case of a 24-year-old man diagnosed with isolated palmar lichen nitidus with dermoscopic features and histopathological confirmation.


Assuntos
Líquen Nítido , Adulto , Humanos , Líquen Nítido/diagnóstico por imagem , Masculino , Doenças Raras , Adulto Jovem
9.
Pediatr Dermatol ; 38 Suppl 2: 110-112, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34272759

RESUMO

Lichen nitidus is a benign skin condition of unknown etiology that is classically described on the trunk, extremities, and genitalia as pinpoint flat-topped papules. In dark-skinned persons, the lesions may appear shiny or even hypopigmented. Lichen nitidus is less often described on the face. We describe a series of pediatric patients with skin of color who presented with the chief complaint of facial skin lightening and had associated clinical findings consistent with lichen nitidus.


Assuntos
Hipopigmentação , Líquen Nítido , Criança , Face , Humanos , Hipopigmentação/diagnóstico , Líquen Nítido/diagnóstico , Pele , Pigmentação da Pele
13.
Skin Res Technol ; 27(2): 272-276, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33174647

RESUMO

BACKGROUND: In clinical, common facial papule dermatosis such as seborrheic keratosis (SK), verruca plana (VP), syringoma and lichen nitidus (LN) is often misdiagnosed. Summarizing in vivo reflectance confocal microscopy (RCM) features of the facial papule dermatosis is helpful in the diagnosis of ambiguous lesions. The purpose of this study was to evaluate the features of SK, VP, syringoma, and LN in RCM. METHODS: We recruited 144 patients referred for unequivocal facial papule dermatosis including 60 patients with SK, 60 patients with VP, 10 patients with syringoma, and 14 patients with LN. The RCM images were evaluated at the epidermis, the dermoepidermal junction, and the dermis from both papule lesions and normal skin. RESULTS: In the epidermis, the cerebriform shape was the main RCM characteristic of SK and the "petal-like" structure was the main RCM characteristic of VP. In the dermoepidermal junction, the RCM features we found were as follows: For SK, the bright dermal papillary rings, the abnormal dermal papilla and the looped vessels were also observed at the abnormal dermal papilla. For VP, the bright dermal papillary rings and the point-like blood vessels were also observed at the round dermal papills. For LN, the round, enlarged, well-circumscribed dermal papillae and the enlarged dermal papillaes were heavily laden with individual highly refractive cells. In the dermis, RCM examination revealed brightly refractile teratogenous sweat tube, designing variably visible bright "moon" structures in all syringoma patients. CONCLUSION: Considering our results, RCM may be useful to non-invasively discriminate SK, VP, syringoma and LN in vivo.


Assuntos
Ceratose Seborreica , Líquen Nítido , Neoplasias Cutâneas , Neoplasias das Glândulas Sudoríparas , Siringoma , Verrugas , Humanos , Ceratose Seborreica/diagnóstico por imagem , Microscopia Confocal , Neoplasias das Glândulas Sudoríparas/diagnóstico por imagem , Verrugas/diagnóstico por imagem
17.
J Cutan Pathol ; 47(9): 834-839, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32285461

RESUMO

Several unusual variants of lichen nitidus are described in the literature. Spinous follicular lichen nitidus with perifollicular granulomas is one such variant characterized by generalized follicular as well as nonfollicular keratotic papules, which show perifollicular granulomas on histopathology as well as a lichenoid granulomatous tissue reaction typical of lichen nitidus. Owing to its atypical clinical and histopathologic manifestations, it raises several clinical possibilities and can be a diagnostic challenge. We report this rare variant of lichen nitidus in a 19-year-old female, and discuss its clinical and histopathological differential diagnosis.


Assuntos
Granuloma/patologia , Folículo Piloso/patologia , Ceratose/patologia , Líquen Nítido/diagnóstico , Pele/patologia , Administração Oral , Adolescente , Antimaláricos/uso terapêutico , Biópsia , Criança , Pré-Escolar , Dapsona/uso terapêutico , Diagnóstico Diferencial , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Líquen Nítido/patologia , Masculino , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , Prednisolona/uso terapêutico , Resultado do Tratamento , Adulto Jovem
18.
J Am Osteopath Assoc ; 119(10): 704, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31566698
19.
Indian J Dermatol Venereol Leprol ; 85(6): 597-604, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31293275

RESUMO

BACKGROUND: Facial papules are a feature of several clinical conditions and may present both diagnostic and therapeutic challenges. AIM: To describe a grouped papular eruption on the nose and adjoining cheeks that has not been well characterized previously. MATERIALS AND METHODS: A series of consecutive patients with a papular eruption predominantly involving nose and cheeks were evaluated, treated and followed up prospectively at tertiary care centers. Demographic details, clinical features, histopathology and response to treatment were recorded. RESULTS: There were five men and six women (mean age 29.9 ± 6.9 years) who had disease for a mean duration of 17.3 ± 11.1 months. All patients presented with a predominantly asymptomatic eruption of monomorphic, pseudovesicular, grouped, skin colored to slightly erythematous papules prominently involving the tip of nose, nasal alae, philtrum and the adjoining cheeks. A total of 15 biopsies from 11 patients were analyzed and the predominant finding was a dense, focal lymphoid infiltrate restricted to the upper dermis with basal cell damage and atrophy of the overlying epidermis. The eruption ran a chronic course from several months to years. LIMITATIONS: Direct immunofluorescence could not be performed except in one case. Immunohistochemical stains for CD4 and CD8 could not be done owing to nonavailability. Phototesting was undertaken in one patient only. CONCLUSION: Small grouped papules on the nose and adjoining skin with a lichenoid histopathology appear to represent a distinct clinicopathological entity. It may be related to actinic lichen nitidus/micropapular variant of polymorphous light eruption.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Dermatoses Faciais/diagnóstico , Líquen Nítido/diagnóstico , Erupções Liquenoides/diagnóstico , Nariz/patologia , Adulto , Dermatoses Faciais/complicações , Dermatoses Faciais/terapia , Feminino , Humanos , Líquen Nítido/complicações , Líquen Nítido/terapia , Erupções Liquenoides/complicações , Erupções Liquenoides/terapia , Masculino , Fototerapia/métodos , Adulto Jovem
20.
Pediatr Dermatol ; 36(5): 690-692, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31313355

RESUMO

Lichen nitidus is a benign inflammatory dermatosis that typically presents in a localized distribution. We present the rare case of a 6-year-old boy with a 1-year history of generalized lichen nitidus with limited access to narrowband ultraviolet B phototherapy. Over the course of a summer, he had complete and lasting resolution of generalized lichen nitidus after daily natural sunlight exposure. This case demonstrates a rare variant of lichen nitidus and a practical treatment alternative to in-office phototherapy.


Assuntos
Helioterapia , Líquen Nítido/terapia , Criança , Humanos , Masculino
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