Narratives of contingency and practices of comparing in the emergence of German molecular genetics (1958-1968).

This article explores the emergence of molecular approaches in German genetic research during the 1958-1968 decade as a period of contingency and alternative possibilities. We introduce "Narratives of Contingency" as an analytical framework to examine how scientists construct a specific narrative - linking past experiences with expectations of future conditions - in order to outline and navigate pathway-decisions in the present. We apply this framework to Hans-Jörg Rheinberger's developmental model of molecular genetics and illustrate how the stages he identifies - the direction of the field, institutional developments, and epistemological demarcations - were already central themes in the comparative practices underlying narratives of contingency in this early period. Narratives of contingency can thus serve as a systematic framework for analyzing the processes through which new scientific fields, institutions, and epistemic horizons emerge, and possibly also for identifying historically plausible fork moments or alternative pathways not taken.

A Conceptual Map of Knowledge Transfer in Occupational Therapy Clinical Practice in Central South Africa.

Introduction: Empirical evidence has confirmed that all types of knowledge (propositional, procedural, personal, and client) contribute to evidence-based practice (EBP) and should be transferred in clinical practice to inform quality service delivery. However, it is unclear how the integration of the types of knowledge that are transferred in clinical practice manifests. Given this gap in understanding, the current research sought to build a conceptual map of knowledge transfer in clinical practice in central South Africa. Method: A qualitative approach was followed, and data to build the conceptual map was obtained from a scoping review that explored the landscape of knowledge transfer in occupational therapy clinical practice, nine semistructured interviews with occupational therapists working in central South Africa, and a Q Method survey. Results: The conceptual map-building process delivered a multidimensional, multidirectional conceptual map consisting of four concepts (theory and research, practice experience, patient-therapist relationship, and patient's voice in clinical practice) and four types of knowledge (propositional, procedural, personal, and client). The results show the integration of the types of knowledge and confirm that knowledge transfer in clinical practice is a complex and ongoing process. Conclusion: The conceptual map, a first of its kind in South Africa, presents empirical evidence of knowledge that is created and transferred in clinical practice in central South Africa. The conceptual map might provide a framework for collaboration amongst all stakeholders, such as patients, occupational therapists, and academics, to produce practice guidelines and occupational outcome measures to support evidence-based clinical practice.

Diversity of ethnomycological knowledge and mushroom foraging culture in a small nation: case of Lithuania.

BACKGROUND: Even in mycophilic nations, mushroom foraging and use traditions may vary from region to region, making it part of cultural diversity and a source of traditional knowledge even in modern and changing societies. The main objective of our study was to investigate mushroom foraging and use traditions in major ethno-regions of Lithuania, to record and analyse whether and how biogeographical and ethno-cultural features influence these traditions, what is their biocultural significance, and whether they persist in the face of societal and environmental change. METHODS: The study conducted a survey among 106 respondents from eleven administrative units of Lithuania, representing four ethno-regions (Zemaitija, Suvalkija, Dzukija and Aukstaitija, the latter divided into North and East). The age of the respondents ranged from 32 to 97 years (mean 70 years, median 68 years). Each respondent was asked six questions about mushroom species and mushroom foraging. The interviews were accompanied by 50 photographs of different mushroom species. The similarity between mushroom foragers' preferences in ethno-regions and the sets of mushroom species used for food and medicine was tested using cluster analysis. Clustering was carried out using Sørensen distances and the method of cluster mean linkage method. RESULTS: The number of mushroom species recognised per respondent was quite similar, with the lowest number of mushroom species recognised in Zemaitija and the highest in Eastern Aukstaitija. Species of no economic or other importance were not well recognised in any of the regions. The number of names applied to mushroom species varied from region to region and did not coincide with the popularity of mushrooms among mushroom pickers. The number of mushroom species used for food was also similar between regions, except for Dzukija, which had the lowest number of species collected. Nine mushroom species were identified by respondents as medicinal mushrooms, the most popular being Amanita muscaria and Inonotus obliquus. When analysing the similarity of mushroom species collected for food and medicine, it was found that ethno-regions clustered into three distinct groups. Two groups depended on the prevailing forest types, while Zemaitija formed a separate cluster defined only by local traditions. CONCLUSIONS: The work represents the largest study of ethnomycological tradition in Lithuania, covering major ethno-regions. We have found that ethnomycological knowledge and tradition are not influenced by any long-term historical events, ethnicity or religion, but rather by the prevailing forest types and regional ethno-culture. Knowledge of edible mushrooms is considered to be inherited from the older generation and is conservative regarding the changes in the set of species consumed and mushroom-related gastronomy. This is also reflected in the safety of mushroom consumption, as mushroom poisoning was very rare among the respondents. Economically insignificant mushrooms are not distinguished and overlooked by traditional mushroom pickers who are not a good source of information on rare or otherwise noteworthy species. However, from a biocultural point of view, mushrooms and mushroom-related traditions remain important for linguistic diversity, traditional knowledge systems and their transmission.

Tracing gender variation in traditional knowledge: participatory tools to promote conservation in a Quilombola community in Brazil.

BACKGROUND: Based on participatory research tools and analysis with a gender focus, we aim to identify the knowledge associated with native plants of the Atlantic Forest in one Quilombola community whose territory is juxtaposed with a protected area, in South Brazil. METHODS: Through the perception of the residents of the Quilombola community of São Roque, we classified the availability, harvesting intensity, abundance, and importance of fourteen plants native to the Atlantic Forest found in their territory. These fourteen plants were selected after initial interviews with a free listing of plants done with all adults (44 people), followed by plant collection and identification. A participatory workshop was built with the community to collect data through three activities: four-cell tool, environment matrix, and importance matrix. To identify the gender nuances in the knowledge within this community, all activities were separated into two groups based on the gender of the 22 participants (9 women and 13 men) and the researchers. RESULTS: The species Pau-pra-tudo (Picrasma crenata), Quina (Coutarea hexandra), and Cipó-milome (Aristolochia triangularis) were similarly classified as important by both groups, which indicates the cultural and environmental relevance associated with them regardless of gender. The perceptions of other species were expressed differently between the groups, showing the variance of the ecological knowledge and the relationship between the sociocultural contexts of gender and the knowledge manifested. The final part of the workshop was a lecture given by two community experts about herbal medicines based on forest species found in the territory. CONCLUSIONS: Based on the multiple forms of results recorded in the workshop, we discuss the demand for inclusion of the traditional community in land management plans of environmental agencies, highlighting how individual characteristics, such as gender, can fill gaps in data about local biodiversity.

The nexus between ecology of foraging and food security: cross-cultural perceptions of wild food plants in Kashmir Himalaya.

BACKGROUND: Wild food plants (WFPs) play an important role in the traditional dietary habits of various indigenous communities worldwide, particularly in mountainous regions. To understand the dynamics of food preferences, cross-cultural studies on food plants should be conducted across diverse ethnic groups in a given area. In this context, the current study investigated the use of WFPs by seven different cultural groups in the Kashmir Himalayan Region. In this area, people gather wild plants and their parts for direct consumption, traditional foods, or sale in local markets. Despite this reliance, documentation of the food system, especially concerning WFPs, is notably lacking. Hence, our research aimed to document WFPs, along with associated traditional ecological knowledge, and identify major threats to their long-term sustainability in Division Muzaffarabad. METHODS: Through a comprehensive approach involving questionnaires, interviews, focus groups, and market surveys, we gathered data from 321 respondents. PCA was performed to analyze threats and plant use using "factoextra" in R software. Origin Pro was used to create a chord diagram, while R software was used to generate a Polar heat map. Additionally, a Venn diagram was created using Bioinformatics software. RESULTS: The study included 321 informants, of whom 75.38% were men and 24.61% were women. In total, 113 plant taxa from 74 genera and 41 botanical families were reported. Polygonaceae and Rosaceae accounted for the majority (17 species each), followed by Lamiaceae (7 species). Leaves were the most used part as food sources (41.04%), followed by fruits (33.33%). Most of the species are consumed as cooked (46.46%) and as raw snacks (37.80%). A total of 47 plant species were collected and cooked as wild vegetables, followed by 40 species used as fruits. This study is the first to describe the market potential and ecological distribution of WFPs in the study area. Cross-comparison showed that utilization of WFPs varies significantly across the region and communities, including their edible parts and mode of consumption. Jaccard index (JI) value ranged from 5.81 to 25. Furthermore, the current study describes 29 WFPs and 10 traditional food dishes that have rarely been documented in Pakistan's ethnobotanical literature. Climate change, invasive species, expansion of agriculture, and plant diseases are some of the most significant threats to WFPs in the study area. CONCLUSIONS: The older age group has more knowledge about WFPs compared to the younger generation, who are not interested in learning about the utilization of WFPs. This lack of interest in information about WFPs among the younger generation can be attributed to their limited access to markets and availability of food plants in the study area. Traditional gathering of food plants has been reduced in younger generations during recent years; therefore, it is crucial to develop effective conservation strategies. These efforts not only safeguard indigenous flora, food knowledge, and cultural heritage, but they also contribute to food security and public health by utilizing local wild foods in the examined area.

Farmers' knowledge in the Swiss canton Valais: cultural heritage with future significance for European veterinary medicine?

BACKGROUND: The demand for natural product-based treatment options for livestock is increasing by animals' owners, veterinarians and policy makers. But at the same time, the traditional knowledge about it is at risk of falling into oblivion in Europe. The present study recorded this knowledge for the linguistically and geographically interesting Swiss canton of Valais. METHOD: Open, semi-structured interviews were used to collect detailed information on formulations and applications, including plant species and natural substances, origin of material, extraction and preparation of herbal products, indication and type of application, dosage, sources of knowledge, frequency of usage and self-assessment of the treatment. RESULTS AND DISCUSSION: In the course of 43 interviews, 173 homemade single species herbal remedy report (HSHR) were recorded. They included 53 plant species from 30 botanical families. Plant species from the botanical families of Asteraceae, Rubiaceae and Cupressaceae were mentioned the most, while the most frequently documented plant species were Coffea arabica L., Juniperus sabina L., Arnica montana L. and Matricaria chamomilla L. For the 173 HSHR, a total of 215 uses were mentioned, most of which were for the treatment of gastrointestinal and metabolic disorders, followed by skin lesions and genito-urinary tract problems. Regional peculiarities emerged, such as the use of Leontopodium alpinum Cass. for diarrhea in the French-speaking Valais, while Matricaria chamomilla and Camellia sinensis L. were used in the German-speaking part instead. In comparison with other regions of Switzerland, 10 plants were reported for the first time, including Juniperus sabina with 18 use reports. CONCLUSION: The daily use on farms and the high satisfaction of farmers with homemade herbal remedies demonstrate their high practical relevance. In conclusion, the traditional regional knowledge about the use of medicinal plants is not only a cultural heritage worth protecting, but also an essential resource for the further development of European veterinary medicine.

Integrating knowledge graphs into machine learning models for survival prediction and biomarker discovery in patients with non-small-cell lung cancer.

Accurate survival prediction for Non-Small Cell Lung Cancer (NSCLC) patients remains a significant challenge for the scientific and clinical community despite decades of advanced analytics. Addressing this challenge not only helps inform the critical aspects of clinical study design and biomarker discovery but also ensures that the 'right patient' receives the 'right treatment'. However, survival prediction is a highly complex task, given the large number of 'omics; and clinical features, as well as the high degree of freedom that drive patient survival. Prior knowledge could play a critical role in uncovering the complexity of a disease and understanding the driving factors affecting a patient's survival. We introduce a methodology for incorporating prior knowledge into machine learning-based models for prediction of patient survival through Knowledge Graphs, demonstrating the advantage of such an approach for NSCLC patients. Using data from patients treated with immuno-oncologic therapies in the POPLAR (NCT01903993) and OAK (NCT02008227) clinical trials, we found that the use of knowledge graphs yielded significantly improved hazard ratios, including in the POPLAR cohort, for models based on biomarker tumor mutation burden compared with those based on knowledge graphs. Use of a model-defined mutational 10-gene signature led to significant overall survival differentiation for both trials. We provide parameterized code for incorporating knowledge graphs into survival analyses for use by the wider scientific community.

The effects of single education session on physiotherapy students' knowledge levels and thoughts on accreditation.

BACKGROUND: and Purpose: In the global landscape, quality assurance is paramount for educational institutions to adapt and thrive. The accreditation process involves evaluating an institution's quality according to standards established by experts and officially documenting its level of quality. This study aimed to assess the impact of a single educational session on physiotherapy and rehabilitation students' awareness and understanding of accreditation processes, recognizing their vital role in quality assurance. METHODS: A pretest-posttest design was employed with 211 students from a physiotherapy and rehabilitation department. Data were collected using a questionnaire assessing demographic information, knowledge about accreditation, and thoughts regarding accreditation. The educational session focused on accreditation criteria and processes, involving presentations and interactive discussions. McNemar's analysis was used to compare the response rates given by the students pre-and post-session. RESULTS: Analysis after the education session revealed a significant increase in students' knowledge of accreditation concepts (p < 0.05). Positive attitudes towards accreditation were reinforced, with students recognizing its importance in education quality. Despite pre-existing positive attitudes, the educational intervention enhanced students' understanding and engagement in accreditation processes with a significant increase in three of the eight questions on thoughts about accreditation (p < 0.05). DISCUSSION: This study underscores the efficacy of educational interventions in fostering student engagement and awareness of accreditation. Findings suggest the need for integrating accreditation education into curricula and advocating its significance through seminars and literature support, ultimately enhancing student participation in quality assurance processes.

Do socioeconomic factors and local human preference determine the hybridization of knowledge in local medical systems?

BACKGROUND: Hybridization between the local medical systems (LMSs) and biomedicine has been the focus of different studies in ethnobiology, primarily due to the increasing access to biomedicine by indigenous peoples and local communities. Studies on hybridization allow for an understanding of the process of developing and evolving local knowledge systems. In this study, we propose a hybridization score to determine how individuals' socioeconomic characteristics and preference between LMS and biomedicine determine the complementarity of therapeutic options. METHODS: We conducted semistructured interviews and applied free listing technique in a rural community in Northeast Brazil to assess the treatments the local population sought and which were preferred. RESULTS: Our analyses showed that the level of schooling was the socioeconomic factor that negatively affected the hybridization process. Individuals with higher levels of schooling tended to prefer LMS strategies less and, consequently, showed a lower probability of hybridizing the two systems. Additionally, older people who preferred LMS strategies showed a greater tendency to adopt hybridization in human health-seeking behavior. CONCLUSIONS: Our findings provide further evidence of the complementarity between different medical systems and demonstrate that socioeconomic factors can affect local knowledge and are responsible for differences in individual propensity to hybridize distinct medical systems.

Disruptive Technologies and Open Science: How Open Should Open Science Be? A 'Third Bioethics' Ethical Framework.

This paper investigates the ethical implications of applying open science (OS) practices on disruptive technologies, such as generative AIs. Disruptive technologies, characterized by their scalability and paradigm-shifting nature, have the potential to generate significant global impact, and carry a risk of dual use. The tension arises between the moral duty of OS to promote societal benefit by democratizing knowledge and the risks associated with open dissemination of disruptive technologies. Van Rennselaer Potter's 'third bioethics' serves as the founding horizon for an ethical framework to govern these tensions. Through theoretical analysis and concrete examples, this paper explores how OS can contribute to a better future or pose threats. Finally, we provide an ethical framework for the intersection between OS and disruptive technologies that tries to go beyond the simple 'as open as possible' tenet, considering openness as an instrumental value for the pursuit of other ethical values rather than as a principle with prima facie moral significance.

Building a Pluriverse of Nursologies: A paradigm for decolonial theory and knowledge development in nursing.

The imperative to decolonise health disciplines underscores the need for a critical examination of the coloniality of nursing knowledge development. Decolonising nursing requires epistemic resistance aimed at exposing and dismantling epistemological hierarchies that marginalise indigenous knowledges. This paper introduces the 'Pluriverse of Nursologies' as paradigm to guide decolonial theorising in nursing. Through a four-part exploration, I first elucidate the coloniality embedded in mainstream nursing knowledge. Next, I offer a decolonial critique of Fawcett's nursing metaparadigm as an exemplar of pyramidal epistemology. I then discuss pluriversality as an approach to decolonising nursing knowledge. Finally, I introduce the Pluriverse of Nursologies (PoN) as a meta-theoretical paradigm for theory and knowledge development that decentres and dismantles the pyramidal epistemology of colonial/modern nursing, and relinks diverse nursologies from marginalised communities to the centre of intellectual nursing discourse, thereby revitalising the theoretical landscape of the discipline.

A model of faulty and faultless disagreement for post-hoc assessments of knowledge utilization in evidence-based policymaking.

When evidence-based policymaking is so often mired in disagreement and controversy, how can we know if the process is meeting its stated goals? We develop a novel mathematical model to study disagreements about adequate knowledge utilization, like those regarding wild horse culling, shark drumlines and facemask policies during pandemics. We find that, when stakeholders disagree, it is frequently impossible to tell whether any party is at fault. We demonstrate the need for a distinctive kind of transparency in evidence-based policymaking, which we call transparency of reasoning. Such transparency is critical to the success of the evidence-based policy movement, as without it, we will be unable to tell whether in any instance a policy was in fact based on evidence.

Knowledge about research and facilitation of co-creation with children. Protocol for the article "scoping review of research about co-creation with children".

Children and young people's participation, as stipulated in the Convention on the Rights of the Child, applies to both matters that directly and indirectly affect children. Participation is in some countries recognized as a fundamental right and children's engagement seen as a valuable resource. Assisted by conceptual understanding of co-creation, children may be enabled to engage and participate in a variety of contexts. Knowledge about research on, and facilitation of, co-creation involving children is the theme of the scoping review presented by this protocol. The protocol outlines a scoping review which is to use a systematic approach to synthesize knowledge of research about co-creation with children. By systematically scoping the existing research about co-creation with children, the review will survey the available literature (evidence), identify key concepts, and uncover gaps in knowledge. The overall objective of this scoping review is to gain knowledge of research conducted about all types of co-creation with children, and to identify the gaps that future research should address. This scoping review acknowledges the existence of multiple definitions of co-creation, which vary depending on different contexts. The review will also recognize several other associated concepts, such as co-production, co-design, co-research, and co- innovation, since they are used interchangeably with or align with the understanding of co-creation being reviewed. The methodological framework outlined by the Joanna Briggs Institute (JBI) for scoping review will be used as a guide for this review. The PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation will be used during the process. The databases, ERIC (Education Resources Information Centre), Teacher Reference Center, Idunn, Oria, Libris, Kungliga biblioteket, ScienceDirect, ProQuest, Scopus, Academic search elite, Web of Science, Google scholar, will be searched for information on academic books and articles, in May 2024. Also grey literature will be searched for relevant academic references. There are no limitations in date of publication. Language will be limited to English, Norwegian, Swedish, and Danish. Following the selection of studies, data will be extracted and analysed. Ethical approval is not required, because only secondary data is collected. Dissemination will include peer-reviewed publications and presentations at conferences regarding public innovation, education, and children`s participations contexts.

Professional, scholar, or knowledge worker? Identity construction of Chinese management researchers amid the research-practice gap.

We move beyond discussing the desirability and feasibility of bridging the research-practice gap to introducing an identity perspective to explore how Chinese management researchers make sense of the research-practice gap and what kinds of career identities are constructed. We conducted a qualitative study among 34 Chinese management researchers working at or studying for a PhD at research-oriented business schools in China. The findings show that management researchers in typical Chinese higher education institutions prefer constructing a single identity (i.e., professional, scholar, or knowledge worker identity) rather than a hybrid identity such as "academic-practitioner" as studies of their Western counterparts suggest. Moreover, before seeking and emulating role models to construct their desired career identities, researchers in China studying management reflexively search for referent groups by identifying either with a narrow disciplinary group (US mainstream management researchers or traditional intellectuals) or a broad group of knowledge workers. Furthermore, this study delineates how researchers with varying career identity narratives adopt corresponding identity work strategies (i.e., redefinition, defense, and distance) suggesting that identity work strategies do not always lead to achieving or preserving positive identity.

People also ask: How does this tool affect exploration-exploitation strategies with regard to prior domain knowledge and search context? An eye-tracking study.

With the diversification of Internet uses, online content type has become richer. Alongside organic results, search engine results pages now provide tools to improve information searching and learning. The People also ask (PAA) box is intended to reduce users' cognitive costs by offering easily accessible information. Nevertheless, there has been scant research on how users actually process it, compared with more traditional content type (i.e., organic results and online documents). The present eye-tracking study explored this question by considering the search context (complex lookup task vs. exploratory task) and users' prior domain knowledge (high vs. low). Main results show that users fixated the PAA box and online documents more to achieve exploratory goals, and fixated organic results more to achieve lookup goals. Users with low knowledge process PAA content at an early stage in their search contrary to their counterparts with high knowledge. Given these results, information system developers should diversify PAA content according to search context and users' prior domain knowledge.