RESUMO
We describe a case of Kaposi's sarcoma in a previously healthy 35-year-old bisexual West Indian man of African descent who was seronegative for the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus-1 (HTLV-1) and who presented with extensive mucocutaneous lesions, weight loss, visceral and generalized lymph node involvement, poor response to combination therapy with vinblastine and inter feron alfa-2a and a short survival of eight months from onset of illness. This is the first document case of Kaposi's sarcoma in Domonica. The presentation is unusal in that it is similar to the aggressive and disseminated Kaposi's sarcoma seen only in AIDS and florid variant of the endemic disease in young men in Equatorial Africa. (AU)
Assuntos
Adulto , Relatos de Casos , Humanos , Masculino , Soronegatividade para HIV , Sarcoma de Kaposi , Neoplasias Cutâneas/diagnóstico , Sarcoma de Kaposi/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Vimblastina/uso terapêutico , Interferon alfa-2/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Antineoplásicos Fitogênicos/uso terapêutico , Evolução FatalRESUMO
Seroprevalence of HHV-8 has been studied in Malaysia, India, Sri Lanka, Thailand, Trinidad, Jamaica and the USA, in both healthy individuals and those infected with HIV. Seroprevalence was found to be low in these countries. In contrast, the African countries of Ghana, Uganda and Zambia showed high seroprevalences in both healthy and HIV-infected populations. This suggests that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity. Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres to show that only 3/82 (3.7 percent) have antibody to HHV-8, demonstrating that there is little, if any, cross-relativity between antibodies to these two gamma viruses. (AU)
Assuntos
Adulto , Idoso , Humanos , Masculino , Feminino , Adolescente , Estudo Comparativo , Criança , Pessoa de Meia-Idade , Infecções por Herpesviridae/epidemiologia , Herpesvirus Humano 8/imunologia , Sarcoma de Kaposi/epidemiologia , África/epidemiologia , Idoso de 80 Anos ou mais , Linfoma de Burkitt/epidemiologia , Região do Caribe/epidemiologia , Neoplasias Nasofaríngeas/epidemiologia , Estudos Soroepidemiológicos , Estados Unidos/epidemiologiaRESUMO
Kaposi's sarcoma (KS) is a multicentric neoplasm thought to arise from both vascular and lymphatic endothelium. It is subdivided into four main categories on the basis of clinical features, course and prognosis. We report a 54 year old Afro-caribbean mle, living in the UK for the past 26 years, with classic features of generlized endemic KS. Because he has never lived on the African continent, the role of genetic rather than environmental factors is favoured in the aetiology of KS in this individual. This disorder is rarely seen in Afro-Caribbeans living in the UK, who have never actually lived in Africia.(AU)
Assuntos
Relatos de Casos , Humanos , Masculino , Pessoa de Meia-Idade , Sarcoma de Kaposi/genética , Neoplasias Cutâneas/genética , África/etnologia , Região do Caribe/etnologia , Reino Unido , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologiaRESUMO
Clinical and pathological features are presented of 3 cases of Kaposi's sarcoma, thought to be the first confirmed cases in the British Commonwealth West Indies. The results of angiography done on one case is given; amyloidosis complicated the natural history in this case. An association between Kaposi's sarcoma and amyloidosis has not been previously noted in the available literature. The rarity of the disease in this predominantly African population, derived mainly from West Africa, is added evidence that environmental factors are responsible for the disease (AU)
