RESUMO
The POEMS syndrome is an unusual disorder manifesting primary as peripheral sensorimotor neuropathy in association with a monoclonal gammopathy. The importance of its recognition is that significant clinical improvement may result from localization and treatment of the underlying plasma cell tumour. AU)
Assuntos
Humanos , Pessoa de Meia-Idade , Masculino , Plasmocitoma/complicações , Neuritos , Doenças do Sistema Endócrino/diagnóstico , Transtornos da Pigmentação/diagnóstico , Síndrome , Disfunção Erétil/etiologia , Edema/etiologia , Plasmocitoma/terapiaRESUMO
A 48-year-old West Indian woman with hypertension sued the district health authority and doctors at the district hospital for negligence in not warning her about adverse effects of minoxidil. The drug had led to excessive hair growth and darkening of the face, causing great distress and limiting her social life.(AU)
Assuntos
Humanos , Pessoa de Meia-Idade , Feminino , Imperícia/legislação & jurisprudência , Minoxidil/efeitos adversos , Educação de Pacientes como Assunto , Hipertensão/tratamento farmacológico , Hipertricose/induzido quimicamente , Minoxidil/administração & dosagem , Transtornos da Pigmentação/induzido quimicamente , Fatores de Risco , Índias OcidentaisRESUMO
From the moment the child begins its life outside the uterus the functions of a very important organ come to an end: the placenta. The placenta is an organic structure that forms at the interface of the ovular membrane and the endometrium. After the fourth month of gestation it facilitates the exchange between the mother and the foetus, regulates its growth and develop - the execution of excretion functions. It was precisely in the human placenta that we found a new substance to cure Vitiligo (leucoderma) which has, since times immemorial, been treated with a group of chemicals of vegetable origin known as psoralenes. These chemicals are now produced synthetically. They are used topically o[r] administered orally together with exposure to sunlight. The results obtained with these treatments have shown them to be unsatisfactory and to have adverse side effects such as: burns, gastritis, hepatotoxicity, carcinogenicity. Vitiligo is a skin disease of unknown etiology which affects 1 percent of the world's population and has no specific treatment. It is characterized by the presence of whitish splotches of depigmented skin generally in the vicinity of articulations but also over the rest of the body. The depigmented skin areas are usually symetrically disposed and the onset of the condition is frequently associated with times of excessive emotional tension. It has not yet been categorically determined if victims of Vitiligo have any alteration of the neurocrine system or of their immune systems which might explain the correlation between the mental condition and the depigmentation of the skin which takes place as an immediate consequence
Assuntos
Humanos , Transtornos da Pigmentação , Vitiligo , Albinismo , Dermatopatias , DermatologiaRESUMO
Retinal detachment, brown mottled areas and microcapillary abnormalities at the posterior pole are previous undescribed retinal features of sickle cell anemia that were found in a series of 76 Jamaicans with homozygous sickle cell anemia. These subjects were consecutive patients in a sickle cell clinic during a one-month period; thus, the series is unique in that bias in selective inclusion of cases with ocular pathology was avoided. Tortuosity of the major retinal vessels, previously reported as a major feature of the retinopathy was found in unaffected relatives of SS patients in the same family with normal hemoglobin genotype. Angioid streaks were not seen in this series. (AU)
Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/complicações , Manifestações Oculares , Doenças Retinianas/etiologia , Fístula Arteriovenosa/etiologia , Genótipo , Hemoglobinas , Transtornos da Pigmentação/etiologia , Descolamento Retiniano/etiologia , Hemorragia Retiniana/etiologia , Pigmentos da Retina , Vasos Retinianos , Retinite/etiologia , Doenças Vasculares/etiologia , JamaicaRESUMO
Hypochromotrichia - a decrease in the normal colour of the hair occurs commonly in kwashiokor, especially in affected Negro infants. The etiology of hypochromotrichia is discussed, with especial reference to malnutrition. In Jamaica, in infants of African stock, 82 per cent. of cases of kwashiorkor showed hypochromotrichia. Field surveys showed the condition, in less marked degree, to be common in poorly nourished infants and young children, who were considered to be possible examples of subclinical, mild kwashiorkor. Aminoacid analyses of hair samples from striking cases of hypochromotrichia from infants with kwashiorkor showed similar results to normal hair samples used as controls. A "hypochromotrichia index" the percentage of affected children aged between 1 and 3 years is suggested as a possible public health indication of the amount of infantile protein deficiency in a malnourished African community (AU)
