Propofol: a new intravenous anaesthetic

Propofol, a new intravenous anaesthetic induction agent, was evaluated on female patients undergoing short surgical procedures. The incidence of pain on injection, apnoea following injection, and the fall of systolic and diastolic blood pressure levels, was similar to that previously reported. There was no significant fall in pulse rate. The quality of anaesthesia during induction was good in all patients who reported they would be happy to receive the drug again (AU)

Management of an insecticide-resistant house fly (Diptera: Muscidae) population by the strategic use of a benzylphenol chemosterilant

Laboratory tests were performed on a strain of Musca domestica L. from the Mission, Tex., screwworm rearing plant which had previously shown insecticide resistance to propoxur, coumaphos, and DDT. The application of the benzylphenol chemosterilant J2644 [2,4-bis (1,1-dimethyl)-6-(4-methoxyphenyl methyl) phenol] to 6-day old females (physiologically mature) reduced egg hatchability to 1 to 3 percent, but 2- to 4-day-old females were less affected (59 to 65 percent egg hatchability)> However, females in the second ovipositional cycle were fertile. Males were not affected. When house fly populations breeding within the Mission rearing plant and Tuxtla Gutierrez, Mexico, rearing plant were treated with 1 percent (wt/wt) J2644, egg hatchability declined from 73 to 2 percent in 8 days and from 86 to 5 percent in 6 days, respectively. The number of house flies collected at survey sites declined to near 0 within 3 to 5 weeks after treatment started. (AU)

Treatment of the enlarged benign prostrate using local injections: a preliminary report

The treatment of benign prostatic hypertrophy with sclerosant injections is described. The results of a preliminary series of 8 patients are reported and the advantages of this treatment in the Caribbean are discussed (AU)

A seven-year field trial of two typhoid vaccines in Guyana

In 1960 about 72,000 Guyanese schoolchildren, aged five to fifteen years, were divided into three similar groups, one of which acted as a control and was given tetanus toxoid, the second was given an acetone-killed typhoid vaccine, and the third a heat-killed-phenolised typhoid vaccine. Two subcutaneous doses of 0.5ml. of reconstituted vaccines were given five weeks apart. An additional 10,000 children received one dose only. The incidence of typhoid fever, diagnosed by the bacteriological isolation of Salmonella typhi, was followed for seven years after vaccination. In those given two doses, 146 cases of typhoid occurred in the control group and 16 and 49 in the acetone and heat-phenol typhoid vaccine groups, showing protection-rates of 88 percent and 65 percent , respectively. In those given one dose of vaccine the protection was somewhat greater, 22 cases occurring in the control group and 1 and 4 in the groups given acetone and heat-phenol vaccines, respectively. Protection showed little diminution until the fifth year after vaccination. (Summary)